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Jeong JW, Cha HJ, Han MH, et al. Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish. Biomol Ther (Seoul). 2018;26(2):146-156doi: 10.4062/biomolther.2016.272.
Jeong, J. W., Cha, H. J., Han, M. H., Hwang, S. J., Lee, D. S., Yoo, J. S., Choi, I. W., Kim, S., Kim, H. S., Kim, G. Y., Hong, S. H., Park, C., Lee, H. J., & Choi, Y. H. (2018). Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish. Biomolecules & therapeutics, 26(2), 146-156. https://doi.org/10.4062/biomolther.2016.272
Jeong, Jin-Woo, et al. "Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish." Biomolecules & therapeutics vol. 26,2 (2018): 146-156. doi: https://doi.org/10.4062/biomolther.2016.272
Jeong JW, Cha HJ, Han MH, Hwang SJ, Lee DS, Yoo JS, Choi IW, Kim S, Kim HS, Kim GY, Hong SH, Park C, Lee HJ, Choi YH. Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish. Biomol Ther (Seoul). 2018 Mar 01;26(2):146-156. doi: 10.4062/biomolther.2016.272. PMID: 28365977; PMCID: PMC5839493.
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Biomol Ther (Seoul). 2018 Mar 01;26(2):146-156. doi: 10.4062/biomolther.2016.272.

Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish.

Biomolecules & therapeutics

Jin-Woo Jeong, Hee-Jae Cha, Min Ho Han, Su Jung Hwang, Dae-Sung Lee, Jong Su Yoo, Il-Whan Choi, Suhkmann Kim, Heui-Soo Kim, Gi-Young Kim, Su Hyun Hong, Cheol Park, Hyo-Jong Lee, Yung Hyun Choi

Affiliations

  1. Anti-Aging Research Center and Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 47227, Republic of Korea.
  2. Departments of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Republic of Korea.
  3. Natural products Research Team, Marine Biodiversity Institute of Korea, Seocheon 33662, Republic of Korea.
  4. Department of Pharmacy, College of Pharmacy, Inje University, Gimhae 50834, Republic of Korea.
  5. Department of Microbiology, College of Medicine, Inje University, Busan 47392, Republic of Korea.
  6. Department of Chemistry, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea.
  7. Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea.
  8. Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of Korea.
  9. Department of Molecular Biology, College of Natural Sciences & Human Ecology, Dongeui University, Busan 47340, Republic of Korea.

PMID: 28365977 PMCID: PMC5839493 DOI: 10.4062/biomolther.2016.272

Abstract

Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have not been fully elucidated. In this study, the potential of spermidine for reducing pro-inflammatory and oxidative effects in lipopolysaccharide (LPS)-stimulated macrophages and zebrafish was explored. Our data indicate that spermidine significantly inhibited the production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin E

Keywords: Anti-Inflammation; Anti-Oxidant; Macrophages; Spermidine; Zebrafish

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