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Garcia M, Pineau A, Guillard O, et al. Low serum selenium concentrations in French patients with measles. Curr Res Transl Med. 2016;65(2):89-91doi: 10.1016/j.retram.2016.10.002.
Garcia, M., Pineau, A., Guillard, O., Ragot, S., Lévêque, N., & Agius, G. (2017). Low serum selenium concentrations in French patients with measles. Current research in translational medicine, 65(2), 89-91. https://doi.org/10.1016/j.retram.2016.10.002
Garcia, M, et al. "Low serum selenium concentrations in French patients with measles." Current research in translational medicine vol. 65,2 (2017): 89-91. doi: https://doi.org/10.1016/j.retram.2016.10.002
Garcia M, Pineau A, Guillard O, Ragot S, Lévêque N, Agius G. Low serum selenium concentrations in French patients with measles. Curr Res Transl Med. 2017 Apr - Jun;65(2):89-91. doi: 10.1016/j.retram.2016.10.002. Epub 2016 Nov 09. PMID: 28447938; PMCID: PMC7104300.
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Curr Res Transl Med. 2017 Apr - Jun;65(2):89-91. doi: 10.1016/j.retram.2016.10.002. Epub 2016 Nov 09.

Low serum selenium concentrations in French patients with measles.

Current research in translational medicine

M Garcia, A Pineau, O Guillard, S Ragot, N Lévêque, G Agius

Affiliations

  1. Laboratoire de virologie, CHU de Poitiers, 2, rue de la Milétrie, CS 90577, 86021 Poitiers cedex, France; UFR médecine et pharmacie, université de Poitiers, 6, rue de la Milétrie, TSA 51115, 86073 Poitiers cedex 9, France.
  2. UFR pharmacie, laboratoire de toxicologie, université de Nantes, 9, rue Bias, BP 53508, 44035 Nantes cedex 1, France.
  3. UFR médecine et pharmacie, université de Poitiers, 6, rue de la Milétrie, TSA 51115, 86073 Poitiers cedex 9, France.
  4. UFR médecine et pharmacie, université de Poitiers, 6, rue de la Milétrie, TSA 51115, 86073 Poitiers cedex 9, France; Inserm CIC 1402, 2, rue de la Milétrie, CS 90577, 86021 Poitiers cedex, France; Centre d'investigation clinique, CHU de Poitiers, 2, rue de la Milétrie, CS 90577, 86021 Poitiers cedex, France.
  5. Laboratoire de virologie, CHU de Poitiers, 2, rue de la Milétrie, CS 90577, 86021 Poitiers cedex, France; UFR médecine et pharmacie, université de Poitiers, 6, rue de la Milétrie, TSA 51115, 86073 Poitiers cedex 9, France. Electronic address: [email protected].

PMID: 28447938 PMCID: PMC7104300 DOI: 10.1016/j.retram.2016.10.002

Abstract

OBJECTIVE: Selenium deficiency adversely affects the clinical outcome of measles in the tropics. In developed countries, serum selenium level has never been investigated during acute measles. The aim of this study was to determine serum selenium concentrations in French patients with acute measles and to seek correlations with clinical and virological findings.

PATIENTS AND METHODS: We studied serum selenium concentrations in 94 French patients with acute measles and in 99 healthy controls matched for age and sex.

RESULTS: The mean of selenium concentration was significantly lower in the patients than in the controls (46.4±14.1μg/L versus 86.5±13.9μg/L, P<0.0001). In the patients, selenium concentrations were not associated with age, sex, vaccination status, clinical signs or specific antibody responses. Selenium levels did not differ significantly between patients with uncomplicated measles (45.8±14.2μg/L) and patients with complications (52.7±13.2μg/L) (P=0.15).

CONCLUSION: Acute measles is associated with significant reduction of selenium level that did not seem to negatively affect the course of the disease suggesting compensating mechanisms in patients from developed countries against the disease.

Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Keywords: French patients; Measles; Selenium

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