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Smith KB, Kang P, Sabbagh MN. The Effect of Statins on Rate of Cognitive Decline in Mild Cognitive Impairment. Alzheimers Dement (N Y). 2017;3(2):149-156doi: 10.1016/j.trci.2017.01.001.
Smith, K. B., Kang, P., Sabbagh, M. N. (2017). The Effect of Statins on Rate of Cognitive Decline in Mild Cognitive Impairment. Alzheimer's & dementia (New York, N. Y.), 3(2), 149-156. https://doi.org/10.1016/j.trci.2017.01.001
Smith, Kyle B, et al. "The Effect of Statins on Rate of Cognitive Decline in Mild Cognitive Impairment." Alzheimer's & dementia (New York, N. Y.) vol. 3,2 (2017): 149-156. doi: https://doi.org/10.1016/j.trci.2017.01.001
Smith KB, Kang P, Sabbagh MN. The Effect of Statins on Rate of Cognitive Decline in Mild Cognitive Impairment. Alzheimers Dement (N Y). 2017 Jun;3(2):149-156. doi: 10.1016/j.trci.2017.01.001. PMID: 28480324; PMCID: PMC5412714.
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Alzheimers Dement (N Y). 2017 Jun;3(2):149-156. doi: 10.1016/j.trci.2017.01.001.

The Effect of Statins on Rate of Cognitive Decline in Mild Cognitive Impairment.

Alzheimer's & dementia (New York, N. Y.)

Kyle B Smith, Paul Kang, Marwan N Sabbagh,

Affiliations

  1. Department of Neurology, Barrow Neurological Institute, Phoenix AZ.
  2. University of Arizona Mel and Enid Zuckerman College of Public Health, Phoenix AZ.

PMID: 28480324 PMCID: PMC5412714 DOI: 10.1016/j.trci.2017.01.001

Abstract

OBJECTIVE: This study's aims are to identify whether or not a relationship between statin use and rate of cognitive decline exists.

BACKGROUND: The relationship between statins and MCI has been investigated in the past with the evidence showing mixed results.

METHODS: 768 subjects were identified with MCI. Subjects were stratified into 6 possible groups according to ApoE4 status and statin use and assessed for decline in cognitive function.

RESULTS: All cognitive assessments trended towards less decline with statin use. ADAS11 showed the biggest difference in mean change between statin users and nonusers (-0.82 vs. -1.22 respectively). Change reached marginal significance on the ADAS11 when stratified by ApoE4 negative subjects.

CONCLUSION: All cognitive assessments trended towards less decline when subjects were concurrently treated with a statin, supporting the position that statins do not have a net negative effect on cognitive assessment and suggests a potential treatment benefit.

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