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Wolf P, Winhofer Y, Krššák M, et al. Heart, lipids and hormones. Endocr Connect. 2017;6(4):R59-R69doi: 10.1530/EC-17-0031.
Wolf, P., Winhofer, Y., Krššák, M., & Krebs, M. (2017). Heart, lipids and hormones. Endocrine connections, 6(4), R59-R69. https://doi.org/10.1530/EC-17-0031
Wolf, Peter, et al. "Heart, lipids and hormones." Endocrine connections vol. 6,4 (2017): R59-R69. doi: https://doi.org/10.1530/EC-17-0031
Wolf P, Winhofer Y, Krššák M, Krebs M. Heart, lipids and hormones. Endocr Connect. 2017 May;6(4):R59-R69. doi: 10.1530/EC-17-0031. Epub 2017 Apr 18. PMID: 28420717; PMCID: PMC5632716.
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Endocr Connect. 2017 May;6(4):R59-R69. doi: 10.1530/EC-17-0031. Epub 2017 Apr 18.

Heart, lipids and hormones.

Endocrine connections

Peter Wolf, Yvonne Winhofer, Martin Krššák, Michael Krebs

Affiliations

  1. Division of Endocrinology and MetabolismDepartment of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  2. High Field MR CentreDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
  3. Division of Endocrinology and MetabolismDepartment of Internal Medicine III, Medical University of Vienna, Vienna, Austria [email protected].

PMID: 28420717 PMCID: PMC5632716 DOI: 10.1530/EC-17-0031

Abstract

Cardiovascular disease is the leading cause of death in general population. Besides well-known risk factors such as hypertension, impaired glucose tolerance and dyslipidemia, growing evidence suggests that hormonal changes in various endocrine diseases also impact the cardiac morphology and function. Recent studies highlight the importance of ectopic intracellular myocardial and pericardial lipid deposition, since even slight changes of these fat depots are associated with alterations in cardiac performance. In this review, we overview the effects of hormones, including insulin, thyroid hormones, growth hormone and cortisol, on heart function, focusing on their impact on myocardial lipid metabolism, cardiac substrate utilization and ectopic lipid deposition, in order to highlight the important role of even subtle hormonal changes for heart function in various endocrine and metabolic diseases.

© 2017 The authors.

Keywords: cardiac steatosis; diabetic cardiomyopathy; hypothyroidism; myocardial lipids

References

  1. J Mol Endocrinol. 2015 Jun;54(3):205-16 - PubMed
  2. Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E983-90 - PubMed
  3. N Engl J Med. 2016 Jul 28;375(4):311-22 - PubMed
  4. Diabetes. 1981 Mar;30(3):219-25 - PubMed
  5. J Clin Invest. 2014 Nov;124(11):4915-25 - PubMed
  6. Cardiovasc Res. 2011 Oct 1;92(1):10-8 - PubMed
  7. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15430-5 - PubMed
  8. Eur Heart J. 2017 Feb 27;:null - PubMed
  9. N Engl J Med. 2001 Feb 15;344(7):501-9 - PubMed
  10. Ann N Y Acad Sci. 1965 Oct 8;131(1):324-33 - PubMed
  11. Endocrinology. 1973 Dec;93(6):1300-8 - PubMed
  12. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E364-71 - PubMed
  13. N Engl J Med. 2007 Mar 15;356(11):1140-51 - PubMed
  14. J Clin Endocrinol Metab. 2013 Mar;98(3):1189-97 - PubMed
  15. Diabetologia. 2016 Nov;59(11):2269-2279 - PubMed
  16. Wien Med Wochenschr. 2014 Aug;164(15-16):320-9 - PubMed
  17. Eur J Endocrinol. 2012 Jun;166(6):993-1002 - PubMed
  18. J Clin Invest. 1985 Nov;76(5):1819-27 - PubMed
  19. J Nucl Cardiol. 2000 May-Jun;7(3):267-76 - PubMed
  20. Am J Physiol Endocrinol Metab. 2015 Apr 15;308(8):E631-40 - PubMed
  21. Physiol Rev. 2005 Jul;85(3):1093-129 - PubMed
  22. Ann Intern Med. 2000 Feb 15;132(4):270-8 - PubMed
  23. Diabetes. 2012 May;61(5):1210-6 - PubMed
  24. J Clin Endocrinol Metab. 2003 Jun;88(6):2527-33 - PubMed
  25. J Clin Endocrinol Metab. 1988 Jan;66(1):51-6 - PubMed
  26. J Biol Chem. 1991 May 5;266(13):8162-70 - PubMed
  27. J Clin Invest. 1987 Feb;79(2):359-66 - PubMed
  28. Metabolism. 2010 May;59(5):703-10 - PubMed
  29. Thyroid. 2010 Aug;20(8):843-9 - PubMed
  30. Circulation. 2013 Jan 1;127(1):143-52 - PubMed
  31. Hepatology. 2008 Jan;47(1):51-8 - PubMed
  32. Endocrinology. 2004 Jun;145(6):2767-74 - PubMed
  33. J Biol Chem. 1992 Feb 15;267(5):2864-7 - PubMed
  34. Nature. 2001 Dec 13;414(6865):799-806 - PubMed
  35. J Clin Endocrinol Metab. 2015 Apr;100(4):E607-10 - PubMed
  36. N Engl J Med. 2004 Feb 12;350(7):664-71 - PubMed
  37. Heart Fail Clin. 2012 Oct;8(4):619-31 - PubMed
  38. J Clin Endocrinol Metab. 1999 Aug;84(8):2664-72 - PubMed
  39. Lancet. 1963 Apr 13;1(7285):785-9 - PubMed
  40. Cell Metab. 2012 Mar 7;15(3):279-91 - PubMed
  41. PLoS One. 2016 Mar 11;11(3):e0151301 - PubMed
  42. PLoS Med. 2005 Sep;2(9):e233 - PubMed
  43. J Clin Endocrinol Metab. 2008 Feb;93(2):497-503 - PubMed
  44. Neuroendocrinology. 2010;92 Suppl 1:96-101 - PubMed
  45. J Am Coll Cardiol. 2006 Oct 17;48(8):1548-51 - PubMed
  46. Circ Res. 2007 Oct 12;101(8):759-67 - PubMed
  47. Diabetologia. 2011 Jul;54(7):1871-8 - PubMed
  48. Clin Endocrinol (Oxf). 2012 Mar;76(3):332-8 - PubMed
  49. N Engl J Med. 2015 Nov 26;373(22):2117-28 - PubMed
  50. Lancet. 2006 May 13;367(9522):1605-17 - PubMed
  51. Science. 2006 May 5;312(5774):734-7 - PubMed
  52. JACC Cardiovasc Imaging. 2015 Dec;8(12 ):1468-1470 - PubMed
  53. J Clin Endocrinol Metab. 2005 Nov;90(11):6300-2 - PubMed
  54. Life Sci. 1996;59(22):1917-22 - PubMed
  55. Endocr Rev. 2005 Aug;26(5):704-28 - PubMed
  56. Clin Endocrinol (Oxf). 2008 Sep;69(3):347-58 - PubMed
  57. Biochem Biophys Res Commun. 2012 Jun 29;423(2):295-300 - PubMed
  58. Circulation. 2012 Aug 28;126(9):1040-9 - PubMed
  59. Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):497-508 - PubMed
  60. J Mol Cell Cardiol. 2011 Jan;50(1):2-5 - PubMed
  61. Endocr Rev. 2004 Feb;25(1):102-52 - PubMed
  62. J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9 - PubMed
  63. Circulation. 2006 Nov 14;114(20):2130-7 - PubMed
  64. Circulation. 2007 Sep 4;116(10):1170-5 - PubMed
  65. J Clin Endocrinol Metab. 2014 Nov;99(11):4299-306 - PubMed
  66. Diabetes Care. 2012 Feb;35(2):389-95 - PubMed
  67. Cell Metab. 2009 Jul;10(1):9-12 - PubMed
  68. J Clin Invest. 2001 Sep;108(5):733-7 - PubMed
  69. PLoS One. 2012;7(12):e50077 - PubMed
  70. Diabetes Care. 2003 Oct;26(10):2949-51 - PubMed
  71. J Am Heart Assoc. 2013 Nov 25;2(6):e000433 - PubMed
  72. J Clin Endocrinol Metab. 2013 Jun;98(6):2326-36 - PubMed
  73. Eur Heart J. 2008 Jun;29(12):1516-22 - PubMed
  74. J Clin Endocrinol Metab. 2001 Dec;86(12):5755-61 - PubMed
  75. Cardiovasc Res. 1994 Apr;28(4):524-7 - PubMed
  76. J Clin Endocrinol Metab. 2014 Nov;99(11):E2144-53 - PubMed
  77. Diabetes. 2002 Oct;51(10):3025-32 - PubMed
  78. Eur J Endocrinol. 2003 Dec;149(6):543-8 - PubMed
  79. J Clin Endocrinol Metab. 2008 Feb;93(2):597-604 - PubMed
  80. ESC Heart Fail. 2016 Sep;3(3):168-176 - PubMed
  81. Heart. 2016 Dec 15;102(24):1945-1952 - PubMed
  82. Diabetologia. 1999 Jan;42(1):113-6 - PubMed
  83. J Am Coll Cardiol. 2003 Jun 18;41(12 ):2275-9 - PubMed
  84. J Clin Endocrinol Metab. 2014 Nov;99(11):E2341-6 - PubMed
  85. J Cardiovasc Magn Reson. 2013 Nov 14;15:103 - PubMed
  86. J Clin Endocrinol Metab. 1999 Jun;84(6):2064-7 - PubMed

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