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Heart, lipids and hormones.

Endocrine connections

Wolf P, Winhofer Y, Krššák M, Krebs M.
PMID: 28420717
Endocr Connect. 2017 May;6(4):R59-R69. doi: 10.1530/EC-17-0031. Epub 2017 Apr 18.

Cardiovascular disease is the leading cause of death in general population. Besides well-known risk factors such as hypertension, impaired glucose tolerance and dyslipidemia, growing evidence suggests that hormonal changes in various endocrine diseases also impact the cardiac morphology and...

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Wolf P, Winhofer Y, Krššák M, et al. Heart, lipids and hormones. Endocr Connect. 2017;6(4):R59-R69doi: 10.1530/EC-17-0031.
Wolf, P., Winhofer, Y., Krššák, M., & Krebs, M. (2017). Heart, lipids and hormones. Endocrine connections, 6(4), R59-R69. https://doi.org/10.1530/EC-17-0031
Wolf, Peter, et al. "Heart, lipids and hormones." Endocrine connections vol. 6,4 (2017): R59-R69. doi: https://doi.org/10.1530/EC-17-0031
Wolf P, Winhofer Y, Krššák M, Krebs M. Heart, lipids and hormones. Endocr Connect. 2017 May;6(4):R59-R69. doi: 10.1530/EC-17-0031. Epub 2017 Apr 18. PMID: 28420717; PMCID: PMC5632716.
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Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies.

Cancers of the head & neck

Tinhofer I, Braunholz D, Klinghammer K.
PMID: 32714605
Cancers Head Neck. 2020 Jul 23;5:9. doi: 10.1186/s41199-020-00056-4. eCollection 2020.

Comprehensive molecular characterization of head and neck squamous cell carcinoma (HNSCC) has led to the identification of distinct molecular subgroups with fundamental differences in biological properties and clinical behavior. Despite improvements in tumor classification and increased understanding about the...

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Tinhofer I, Braunholz D, Klinghammer K. Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies. Cancers Head Neck. 2020;5:9doi: 10.1186/s41199-020-00056-4.
Tinhofer, I., Braunholz, D., & Klinghammer, K. (2020). Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies. Cancers of the head & neck, 59. https://doi.org/10.1186/s41199-020-00056-4
Tinhofer, Ingeborg, et al. "Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies." Cancers of the head & neck vol. 5 (2020): 9. doi: https://doi.org/10.1186/s41199-020-00056-4
Tinhofer I, Braunholz D, Klinghammer K. Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies. Cancers Head Neck. 2020 Jul 23;5:9. doi: 10.1186/s41199-020-00056-4. eCollection 2020. PMID: 32714605; PMCID: PMC7376675.
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Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial.

Frontiers in oncology

Stelmes JJ, Gregoire V, Poorten VV, Golusiñski W, Szewczyk M, Jones T, Ansarin M, Broglie MA, Giger R, Klussmann JP, Evans M, Bourhis J, Leemans CR, Spriano G, Dietz A, Hunter K, Zimmermann F, Tinhofer I, Patterson JM, Quaglini S, Govaerts AS, Fortpied C, Simon C.
PMID: 31696052
Front Oncol. 2019 Oct 22;9:999. doi: 10.3389/fonc.2019.00999. eCollection 2019.

Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve...

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Stelmes JJ, Gregoire V, Poorten VV, et al. Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial. Front Oncol. 2019;9:999doi: 10.3389/fonc.2019.00999.
Stelmes, J. J., Gregoire, V., Poorten, V. V., Golusiñski, W., Szewczyk, M., Jones, T., Ansarin, M., Broglie, M. A., Giger, R., Klussmann, J. P., Evans, M., Bourhis, J., Leemans, C. R., Spriano, G., Dietz, A., Hunter, K., Zimmermann, F., Tinhofer, I., Patterson, J. M., Quaglini, S., Govaerts, A. S., Fortpied, C., & Simon, C. (2019). Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial. Frontiers in oncology, 9999. https://doi.org/10.3389/fonc.2019.00999
Stelmes, Jean-Jacques, et al. "Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial." Frontiers in oncology vol. 9 (2019): 999. doi: https://doi.org/10.3389/fonc.2019.00999
Stelmes JJ, Gregoire V, Poorten VV, Golusiñski W, Szewczyk M, Jones T, Ansarin M, Broglie MA, Giger R, Klussmann JP, Evans M, Bourhis J, Leemans CR, Spriano G, Dietz A, Hunter K, Zimmermann F, Tinhofer I, Patterson JM, Quaglini S, Govaerts AS, Fortpied C, Simon C. Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial. Front Oncol. 2019 Oct 22;9:999. doi: 10.3389/fonc.2019.00999. eCollection 2019. PMID: 31696052; PMCID: PMC6817682.
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Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery.

International journal of endocrinology

Pacini G, Tura A, Winhofer Y, Kautzky-Willer A.
PMID: 22577378
Int J Endocrinol. 2012;2012:247392. doi: 10.1155/2012/247392. Epub 2012 Apr 19.

Background and Aims. Women with former gestational diabetes (fGDM) are characterized by impaired beta-cell function (BC). Incretin hormones contribute to insulin secretion after oral administration of glucose. We aimed to assess the possible role of incretins on altered insulin...

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Pacini G, Tura A, Winhofer Y, et al. Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery. Int J Endocrinol. 2012;2012:247392doi: 10.1155/2012/247392.
Pacini, G., Tura, A., Winhofer, Y., & Kautzky-Willer, A. (2012). Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery. International journal of endocrinology, 2012247392. https://doi.org/10.1155/2012/247392
Pacini, G, et al. "Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery." International journal of endocrinology vol. 2012 (2012): 247392. doi: https://doi.org/10.1155/2012/247392
Pacini G, Tura A, Winhofer Y, Kautzky-Willer A. Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery. Int J Endocrinol. 2012;2012:247392. doi: 10.1155/2012/247392. Epub 2012 Apr 19. PMID: 22577378; PMCID: PMC3345226.
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Long-term Use of Ultrasound for Locating Optimal LVA Sites: A Descriptive Data Analysis.

Journal of reconstructive microsurgery

Mohos B, Czedik-Eysenberg M, Steinbacher J, Tinhofer I, Meng S, Tzou CJ.
PMID: 34820800
J Reconstr Microsurg. 2021 Nov 24; doi: 10.1055/s-0041-1740124. Epub 2021 Nov 24.

BACKGROUND:  Preoperative mapping of lymphatic vessels for lymphovenous anastomosis (LVA) surgery is frequently performed by indocyanine green (ICG) lymphography solely; however, other imaging modalities, such as ultrasound (US), might be more efficient, particularly for Caucasian patients. We present our...

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Mohos B, Czedik-Eysenberg M, Steinbacher J, et al. Long-term Use of Ultrasound for Locating Optimal LVA Sites: A Descriptive Data Analysis. J Reconstr Microsurg. 2021;doi: 10.1055/s-0041-1740124.
Mohos, B., Czedik-Eysenberg, M., Steinbacher, J., Tinhofer, I., Meng, S., & Tzou, C. J. (2021). Long-term Use of Ultrasound for Locating Optimal LVA Sites: A Descriptive Data Analysis. Journal of reconstructive microsurgery, . https://doi.org/10.1055/s-0041-1740124
Mohos, Balazs, et al. "Long-term Use of Ultrasound for Locating Optimal LVA Sites: A Descriptive Data Analysis." Journal of reconstructive microsurgery vol. (2021). doi: https://doi.org/10.1055/s-0041-1740124
Mohos B, Czedik-Eysenberg M, Steinbacher J, Tinhofer I, Meng S, Tzou CJ. Long-term Use of Ultrasound for Locating Optimal LVA Sites: A Descriptive Data Analysis. J Reconstr Microsurg. 2021 Nov 24; doi: 10.1055/s-0041-1740124. Epub 2021 Nov 24. PMID: 34820800.
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A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial.

European journal of cancer (Oxford, England : 1990)

Galot R, Le Tourneau C, Saada-Bouzid E, Daste A, Even C, Debruyne P, Henry S, Zanetta S, Rutten A, Licitra L, Canon JL, Kaminsky MC, Specenier P, Rottey S, Guigay J, Kong A, Tinhofer I, Borcoman E, Dirix L, Raveloarivahy T, Fortpied C, Vanlancker M, Morfouace M, Govaerts AS, Machiels JP.
PMID: 34638090
Eur J Cancer. 2021 Oct 09;158:17-26. doi: 10.1016/j.ejca.2021.09.003. Epub 2021 Oct 09.

PURPOSE: Monalizumab is a monoclonal antibody targeting the inhibitory natural killer group 2A (NKG2A) receptor localised on natural killer (NK) and T cells. Its ligand, the human leukocyte antigen E (HLA-E), is overexpressed in squamous cell carcinoma of the...

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Galot R, Le Tourneau C, Saada-Bouzid E, et al. A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial. Eur J Cancer. 2021;158:17-26doi: 10.1016/j.ejca.2021.09.003.
Galot, R., Le Tourneau, C., Saada-Bouzid, E., Daste, A., Even, C., Debruyne, P., Henry, S., Zanetta, S., Rutten, A., Licitra, L., Canon, J. L., Kaminsky, M. C., Specenier, P., Rottey, S., Guigay, J., Kong, A., Tinhofer, I., Borcoman, E., Dirix, L., Raveloarivahy, T., Fortpied, C., Vanlancker, M., Morfouace, M., Govaerts, A. S., & Machiels, J. P. (2021). A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial. European journal of cancer (Oxford, England : 1990), 15817-26. https://doi.org/10.1016/j.ejca.2021.09.003
Galot, Rachel, et al. "A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial." European journal of cancer (Oxford, England : 1990) vol. 158 (2021): 17-26. doi: https://doi.org/10.1016/j.ejca.2021.09.003
Galot R, Le Tourneau C, Saada-Bouzid E, Daste A, Even C, Debruyne P, Henry S, Zanetta S, Rutten A, Licitra L, Canon JL, Kaminsky MC, Specenier P, Rottey S, Guigay J, Kong A, Tinhofer I, Borcoman E, Dirix L, Raveloarivahy T, Fortpied C, Vanlancker M, Morfouace M, Govaerts AS, Machiels JP. A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial. Eur J Cancer. 2021 Oct 09;158:17-26. doi: 10.1016/j.ejca.2021.09.003. Epub 2021 Oct 09. PMID: 34638090.
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The role of Next-Generation Sequencing in tumoral radiosensitivity prediction.

Clinical and translational radiation oncology

Bibault JE, Tinhofer I.
PMID: 29658008
Clin Transl Radiat Oncol. 2017 Apr 09;3:16-20. doi: 10.1016/j.ctro.2017.03.002. eCollection 2017 Apr.

Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology...

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Bibault JE, Tinhofer I. The role of Next-Generation Sequencing in tumoral radiosensitivity prediction. Clin Transl Radiat Oncol. 2017;3:16-20doi: 10.1016/j.ctro.2017.03.002.
Bibault, J. E., & Tinhofer, I. (2017). The role of Next-Generation Sequencing in tumoral radiosensitivity prediction. Clinical and translational radiation oncology, 316-20. https://doi.org/10.1016/j.ctro.2017.03.002
Bibault, Jean-Emmanuel, and Tinhofer, Ingeborg. "The role of Next-Generation Sequencing in tumoral radiosensitivity prediction." Clinical and translational radiation oncology vol. 3 (2017): 16-20. doi: https://doi.org/10.1016/j.ctro.2017.03.002
Bibault JE, Tinhofer I. The role of Next-Generation Sequencing in tumoral radiosensitivity prediction. Clin Transl Radiat Oncol. 2017 Apr 09;3:16-20. doi: 10.1016/j.ctro.2017.03.002. eCollection 2017 Apr. PMID: 29658008; PMCID: PMC5893518.
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SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy.

Clinical and translational radiation oncology

De-Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Jawad JA, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Bayer C, Belka C, Pigorsch S, Combs SE, Lohaus F, Linge A, Krause M, Baumann M, Zips D, Menegakis A.
PMID: 29594214
Clin Transl Radiat Oncol. 2017 Jul 14;5:28-36. doi: 10.1016/j.ctro.2017.06.004. eCollection 2017 Aug.

INTRODUCTION: Outcome after postoperative radiochemotherapy (RT-CT) for patients with advanced head and neck squamous cell carcinomas (HNSCC) remains unsatisfactory, especially among those with HPV negative tumours. Therefore, new biomarkers are needed to further define subgroups for individualised therapeutic approaches....

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De-Colle C, Mönnich D, Welz S, et al. SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. Clin Transl Radiat Oncol. 2017;5:28-36doi: 10.1016/j.ctro.2017.06.004.
De-Colle, C., Mönnich, D., Welz, S., Boeke, S., Sipos, B., Fend, F., Mauz, P. S., Tinhofer, I., Budach, V., Jawad, J. A., Stuschke, M., Balermpas, P., Rödel, C., Grosu, A. L., Abdollahi, A., Debus, J., Bayer, C., Belka, C., Pigorsch, S., Combs, S. E., Lohaus, F., Linge, A., Krause, M., Baumann, M., Zips, D., & Menegakis, A. (2017). SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. Clinical and translational radiation oncology, 528-36. https://doi.org/10.1016/j.ctro.2017.06.004
De-Colle, Chiara, et al. "SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy." Clinical and translational radiation oncology vol. 5 (2017): 28-36. doi: https://doi.org/10.1016/j.ctro.2017.06.004
De-Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Jawad JA, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Bayer C, Belka C, Pigorsch S, Combs SE, Lohaus F, Linge A, Krause M, Baumann M, Zips D, Menegakis A. SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. Clin Transl Radiat Oncol. 2017 Jul 14;5:28-36. doi: 10.1016/j.ctro.2017.06.004. eCollection 2017 Aug. PMID: 29594214; PMCID: PMC5833920.
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A Case of "Late-Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in the CYP24A1 Gene.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Wolf P, Müller-Sacherer T, Baumgartner-Parzer S, Winhofer Y, Kroo J, Gessl A, Luger A, Krebs M.
PMID: 24518185
Endocr Pract. 2014 May;20(5):e91-5. doi: 10.4158/EP13479.CR.

OBJECTIVE: Mutations in the 24-hydroxylase gene, CYP24A1, have recently been reported to cause idiopathic infantile hypercalcemia (IIH), a rare disease presenting in the first year of life that is characterized by increased sensitivity to vitamin D, leading to severe...

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Wolf P, Müller-Sacherer T, Baumgartner-Parzer S, et al. A Case of "Late-Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in the CYP24A1 Gene. Endocr Pract. 2014;20(5):e91-5doi: 10.4158/EP13479.CR.
Wolf, P., Müller-Sacherer, T., Baumgartner-Parzer, S., Winhofer, Y., Kroo, J., Gessl, A., Luger, A., & Krebs, M. (2014). A Case of "Late-Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in the CYP24A1 Gene. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 20(5), e91-5. https://doi.org/10.4158/EP13479.CR
Wolf, Peter, et al. "A Case of "Late-Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in the CYP24A1 Gene." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists vol. 20,5 (2014): e91-5. doi: https://doi.org/10.4158/EP13479.CR
Wolf P, Müller-Sacherer T, Baumgartner-Parzer S, Winhofer Y, Kroo J, Gessl A, Luger A, Krebs M. A Case of "Late-Onset" Idiopathic Infantile Hypercalcemia Secondary to Mutations in the CYP24A1 Gene. Endocr Pract. 2014 May;20(5):e91-5. doi: 10.4158/EP13479.CR. PMID: 24518185.
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Purification and Characterization of Chorismate Synthase from Euglena gracilis: Comparison with Chorismate Synthases of Plant and Microbial Origin.

Plant physiology

Schaller A, van Afferden M, Windhofer V, Bülow S, Abel G, Schmid J, Amrhein N.
PMID: 16668543
Plant Physiol. 1991 Dec;97(4):1271-9. doi: 10.1104/pp.97.4.1271.

Chorismate synthase was purified 1200-fold from Euglena gracilis. The molecular mass of the native enzyme is in the range of 110 to 138 kilodaltons as judged by gel filtration. The molecular mass of the subunit was determined to be...

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Schaller A, van Afferden M, Windhofer V, et al. Purification and Characterization of Chorismate Synthase from Euglena gracilis: Comparison with Chorismate Synthases of Plant and Microbial Origin. Plant Physiol. 1991;97(4):1271-9doi: 10.1104/pp.97.4.1271.
Schaller, A., van Afferden, M., Windhofer, V., Bülow, S., Abel, G., Schmid, J., & Amrhein, N. (1991). Purification and Characterization of Chorismate Synthase from Euglena gracilis: Comparison with Chorismate Synthases of Plant and Microbial Origin. Plant physiology, 97(4), 1271-9. https://doi.org/10.1104/pp.97.4.1271
Schaller, A, et al. "Purification and Characterization of Chorismate Synthase from Euglena gracilis: Comparison with Chorismate Synthases of Plant and Microbial Origin." Plant physiology vol. 97,4 (1991): 1271-9. doi: https://doi.org/10.1104/pp.97.4.1271
Schaller A, van Afferden M, Windhofer V, Bülow S, Abel G, Schmid J, Amrhein N. Purification and Characterization of Chorismate Synthase from Euglena gracilis: Comparison with Chorismate Synthases of Plant and Microbial Origin. Plant Physiol. 1991 Dec;97(4):1271-9. doi: 10.1104/pp.97.4.1271. PMID: 16668543; PMCID: PMC1081158.
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Massive and massless Dirac fermions in Pb1-xSnxTe topological crystalline insulator probed by magneto-optical absorption.

Scientific reports

Assaf BA, Phuphachong T, Volobuev VV, Inhofer A, Bauer G, Springholz G, de Vaulchier LA, Guldner Y.
PMID: 26843435
Sci Rep. 2016 Feb 04;6:20323. doi: 10.1038/srep20323.

Dirac fermions in condensed matter physics hold great promise for novel fundamental physics, quantum devices and data storage applications. IV-VI semiconductors, in the inverted regime, have been recently shown to exhibit massless topological surface Dirac fermions protected by crystalline...

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Assaf BA, Phuphachong T, Volobuev VV, et al. Massive and massless Dirac fermions in Pb1-xSnxTe topological crystalline insulator probed by magneto-optical absorption. Sci Rep. 2016;6:20323doi: 10.1038/srep20323.
Assaf, B. A., Phuphachong, T., Volobuev, V. V., Inhofer, A., Bauer, G., Springholz, G., de Vaulchier, L. A., & Guldner, Y. (2016). Massive and massless Dirac fermions in Pb1-xSnxTe topological crystalline insulator probed by magneto-optical absorption. Scientific reports, 620323. https://doi.org/10.1038/srep20323
Assaf, B A, et al. "Massive and massless Dirac fermions in Pb1-xSnxTe topological crystalline insulator probed by magneto-optical absorption." Scientific reports vol. 6 (2016): 20323. doi: https://doi.org/10.1038/srep20323
Assaf BA, Phuphachong T, Volobuev VV, Inhofer A, Bauer G, Springholz G, de Vaulchier LA, Guldner Y. Massive and massless Dirac fermions in Pb1-xSnxTe topological crystalline insulator probed by magneto-optical absorption. Sci Rep. 2016 Feb 04;6:20323. doi: 10.1038/srep20323. PMID: 26843435; PMCID: PMC4740886.
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Contact gating at GHz frequency in graphene.

Scientific reports

Wilmart Q, Inhofer A, Boukhicha M, Yang W, Rosticher M, Morfin P, Garroum N, Fève G, Berroir JM, Plaçais B.
PMID: 26879709
Sci Rep. 2016 Feb 16;6:21085. doi: 10.1038/srep21085.

The paradigm of graphene transistors is based on the gate modulation of the channel carrier density by means of a local channel gate. This standard architecture is subject to the scaling limit of the channel length and further restrictions...

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Wilmart Q, Inhofer A, Boukhicha M, et al. Contact gating at GHz frequency in graphene. Sci Rep. 2016;6:21085doi: 10.1038/srep21085.
Wilmart, Q., Inhofer, A., Boukhicha, M., Yang, W., Rosticher, M., Morfin, P., Garroum, N., Fève, G., Berroir, J. M., & Plaçais, B. (2016). Contact gating at GHz frequency in graphene. Scientific reports, 621085. https://doi.org/10.1038/srep21085
Wilmart, Q, et al. "Contact gating at GHz frequency in graphene." Scientific reports vol. 6 (2016): 21085. doi: https://doi.org/10.1038/srep21085
Wilmart Q, Inhofer A, Boukhicha M, Yang W, Rosticher M, Morfin P, Garroum N, Fève G, Berroir JM, Plaçais B. Contact gating at GHz frequency in graphene. Sci Rep. 2016 Feb 16;6:21085. doi: 10.1038/srep21085. PMID: 26879709; PMCID: PMC4754686.
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