Display options
Cite
Okita Y, Rcom-H'cheo-Gauthier AN, Goulding M, et al. Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies. Front Neurosci. 2017;11:114doi: 10.3389/fnins.2017.00114.
Okita, Y., Rcom-H'cheo-Gauthier, A. N., Goulding, M., Chung, R. S., Faller, P., & Pountney, D. L. (2017). Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies. Frontiers in neuroscience, 11114. https://doi.org/10.3389/fnins.2017.00114
Okita, Yuho, et al. "Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies." Frontiers in neuroscience vol. 11 (2017): 114. doi: https://doi.org/10.3389/fnins.2017.00114
Okita Y, Rcom-H'cheo-Gauthier AN, Goulding M, Chung RS, Faller P, Pountney DL. Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies. Front Neurosci. 2017 Apr 04;11:114. doi: 10.3389/fnins.2017.00114. eCollection 2017. PMID: 28420950; PMCID: PMC5380005.
Copy Download .nbib Format: NLM
Share it on

Front Neurosci. 2017 Apr 04;11:114. doi: 10.3389/fnins.2017.00114. eCollection 2017.

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.

Frontiers in neuroscience

Yuho Okita, Alexandre N Rcom-H'cheo-Gauthier, Michael Goulding, Roger S Chung, Peter Faller, Dean L Pountney

Affiliations

  1. Menzies Health Institute Queensland, Griffith UniversityGold Coast, QLD, Australia.
  2. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie UniversitySydney, NSW, Australia.
  3. Centre National de la Recherche Scientifique, Institut de Chimie UMR 7177, Université de StrasbourgStrasbourg, France.
  4. University of Strasbourg Institute for Advanced StudyStrasbourg, France.

PMID: 28420950 PMCID: PMC5380005 DOI: 10.3389/fnins.2017.00114

Abstract

Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/(II) redox cycling can generate reactive oxygen species. Copper accumulates in the brain with aging and has been shown to bind alpha-synuclein and initiate its aggregation, the primary aetiological factor in Parkinson's disease (PD), and other alpha-synucleinopathies. In PD, total tissue copper is decreased, including neuromelanin-bound copper and there is a reduction in copper transporter CTR-1. Conversely cerebrospinal fluid (CSF) copper is increased. MT-1/2 expression is increased in activated astrocytes in alpha-synucleinopathies, yet expression of the neuronal MT-3 isoform may be reduced. MTs have been implicated in inflammatory states to perform one-way exchange of copper, releasing free zinc and recent studies have found copper bound to alpha-synuclein is transferred to the MT-3 isoform

Keywords: Parkinson's disease; copper; dementia with lewy bodies; metallothionein; multiple system atrophy; α-synuclein

References

  1. Int Immunopharmacol. 2004 Oct;4(10-11):1307-18 - PubMed
  2. Mov Disord. 2004 Jan;19(1):60-7 - PubMed
  3. JAMA. 2014 Apr 23-30;311(16):1670-83 - PubMed
  4. J Biol Chem. 1960 Dec;235:3460-5 - PubMed
  5. J Biol Chem. 2008 May 30;283(22):15349-58 - PubMed
  6. J Parkinsons Dis. 2013;3(1):1-11 - PubMed
  7. Neurotox Res. 2011 Jan;19(1):115-22 - PubMed
  8. Nat Rev Drug Discov. 2004 Mar;3(3):205-14 - PubMed
  9. Oxid Med Cell Longev. 2014;2014:147251 - PubMed
  10. Prog Histochem Cytochem. 2009;44(1):1-27 - PubMed
  11. Nat Med. 2015 Jul;21(7):802-7 - PubMed
  12. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:116-20 - PubMed
  13. J Alzheimers Dis. 2016;51(1):81-95 - PubMed
  14. Nat Rev Neurosci. 2011 Sep 02;12(10):550 - PubMed
  15. Drugs Aging. 2001;18(9):685-716 - PubMed
  16. Biol Trace Elem Res. 1992 Sep;34(3):237-48 - PubMed
  17. Neurosci Lett. 2007 May 11;418(1):72-6 - PubMed
  18. Cell Mol Life Sci. 2012 Nov;69(21):3665-81 - PubMed
  19. Neurology. 2013 Mar 12;80(11):1062-4 - PubMed
  20. Mov Disord. 2014 Dec;29(14):1720-41 - PubMed
  21. Cell Death Dis. 2012 Jul 19;3:e350 - PubMed
  22. Metallomics. 2016 Sep 1;8(9):863-73 - PubMed
  23. Front Neuroanat. 2015 Jul 08;9:91 - PubMed
  24. Brain Res. 2009 Jan 12;1248:14-21 - PubMed
  25. J Alzheimers Dis. 2016;51(3):637-56 - PubMed
  26. Acta Biochim Pol. 2010;57(4):561-6 - PubMed
  27. Aging Cell. 2013 Oct;12(5):823-32 - PubMed
  28. J Chem Neuroanat. 2008 Sep;36(1):1-5 - PubMed
  29. Nature. 2013 Sep 5;501(7465):45-51 - PubMed
  30. Curr Opin Chem Biol. 2008 Apr;12(2):222-8 - PubMed
  31. Lancet. 1987 Aug 1;2(8553):238-41 - PubMed
  32. Ann Neurol. 2014 Jan;75(1):127-37 - PubMed
  33. Am J Physiol. 1998 Apr;274(4 Pt 2):F783-90 - PubMed
  34. Curr Genomics. 2013 Dec;14(8):486-501 - PubMed
  35. Nat Genet. 1996 Jun;13(2):219-22 - PubMed
  36. Histol Histopathol. 2012 Nov;27(11):1459-70 - PubMed
  37. Nature. 1998 Apr 9;392(6676):605-8 - PubMed
  38. Cell. 1984 May;37(1):263-72 - PubMed
  39. Neurobiol Dis. 2015 Sep;81:76-92 - PubMed
  40. Indian J Psychiatry. 2010 Apr;52(2):140-4 - PubMed
  41. Curr Opin Neurol. 2012 Aug;25(4):429-32 - PubMed
  42. Chem Biol Interact. 1985 Nov;55(3):347-56 - PubMed
  43. Neurobiol Aging. 2014 Apr;35(4):858-66 - PubMed
  44. Nature. 1984 Apr 5-11;308(5959):513-9 - PubMed
  45. Exp Brain Res. 2007 Nov;183(2):171-80 - PubMed
  46. Talanta. 1998 Jun;46(2):243-54 - PubMed
  47. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S158-68 - PubMed
  48. Curr Top Behav Neurosci. 2015;22:271-301 - PubMed
  49. Neuron. 2008 Jul 10;59(1):43-55 - PubMed
  50. Mov Disord. 2017 Mar;32(3):319-324 - PubMed
  51. Brain Res Mol Brain Res. 2005 Mar 24;134(1):67-75 - PubMed
  52. Genomics. 1990 Nov;8(3):513-8 - PubMed
  53. Neuron. 2001 Jun;30(3):665-76 - PubMed
  54. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515 - PubMed
  55. Brain Res. 2010 Mar 10;1319:118-30 - PubMed
  56. J Biol Chem. 2016 Jan 15;291(3):1092-102 - PubMed
  57. Inorg Chem. 2013 Feb 4;52(3):1358-67 - PubMed
  58. Inorg Chem. 2015 May 18;54(10):4744-51 - PubMed
  59. J Am Chem Soc. 2008 Jun 18;130(24):7766-73 - PubMed
  60. Traffic. 2014 Feb;15(2):230-44 - PubMed
  61. Toxicology. 1981;20(4):275-9 - PubMed
  62. Eur J Epidemiol. 2011 Jun;26 Suppl 1:S1-58 - PubMed
  63. J Biol Chem. 2004 Mar 12;279(11):10710-9 - PubMed
  64. Sci Rep. 2011;1:11 - PubMed
  65. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6333-7 - PubMed
  66. Nat Chem Biol. 2008 Jun;4(6):366-72 - PubMed
  67. Neurobiol Dis. 2016 Sep;93:115-20 - PubMed
  68. Mov Disord. 2009 Apr 15;24(5):647-54 - PubMed
  69. J Neurosci. 2002 Apr 1;22(7):2780-91 - PubMed
  70. FASEB J. 2004 Apr;18(6):637-47 - PubMed
  71. J Biol Inorg Chem. 2011 Oct;16(7):1103-13 - PubMed
  72. Neurochem Int. 2013 Sep;63(3):201-29 - PubMed
  73. FEBS J. 2010 Jul;277(14):2921-30 - PubMed
  74. Biochem J. 1999 Jun 15;340 ( Pt 3):821-8 - PubMed
  75. Mol Neurodegener. 2016 Apr 02;11:25 - PubMed
  76. Curr Pharm Biotechnol. 2013;14(4):408-13 - PubMed
  77. PLoS One. 2010 Aug 11;5(8):e12030 - PubMed
  78. Cold Spring Harb Perspect Med. 2017 Feb 17;:null - PubMed
  79. Cell Mol Life Sci. 2012 Nov;69(21):3683-700 - PubMed
  80. Front Aging Neurosci. 2010 May 21;2:17 - PubMed
  81. Metallomics. 2013 Jan;5(1):43-51 - PubMed
  82. PLoS One. 2012;7(6):e38545 - PubMed
  83. Chembiochem. 2015 Nov 2;16(16):2319-28 - PubMed
  84. Int J Mol Sci. 2017 Feb 22;18(2): - PubMed
  85. Nat Med. 2017 Feb 7;23 (2):1-13 - PubMed
  86. Front Neurosci. 2016 Dec 20;10 :570 - PubMed
  87. Neurochem Int. 1993 Dec;23(6):561-6 - PubMed
  88. Mediators Inflamm. 2013;2013:342931 - PubMed
  89. J Trace Elem Med Biol. 2007;21 Suppl 1:35-9 - PubMed
  90. Clin Sci (Lond). 2016 Apr;130(8):565-74 - PubMed
  91. Mol Cell Biol. 1989 Dec;9(12):5738-41 - PubMed
  92. Neurotox Res. 2009 May;15(4):381-9 - PubMed
  93. Dev Biol. 1986 Dec;118(2):549-55 - PubMed
  94. Free Radic Biol Med. 2011 Jun 1;50(11):1471-9 - PubMed
  95. Nature. 2009 Aug 13;460(7257):823-30 - PubMed
  96. Cell. 2012 May 25;149(5):1048-59 - PubMed
  97. ACS Chem Neurosci. 2016 Jan 20;7(1):119-29 - PubMed
  98. Mol Med Rep. 2015 Mar;11(3):1582-6 - PubMed
  99. FEBS J. 2010 Jul;277(14):2931-9 - PubMed
  100. Postgrad Med J. 2004 Aug;80(946):452-8 - PubMed
  101. Nat Neurosci. 2005 May;8(5):657-63 - PubMed
  102. Int J Nanomedicine. 2013;8:1477-88 - PubMed
  103. Cell. 2009 Oct 16;139(2):440.e1-2 - PubMed
  104. J Inorg Biochem. 2016 Oct;163:292-300 - PubMed
  105. Front Cell Neurosci. 2015 Nov 12;9:437 - PubMed
  106. J Neurosci. 2013 Jun 12;33(24):10154-64 - PubMed
  107. J Neurol Sci. 2007 Jun 15;257(1-2):221-39 - PubMed
  108. Lancet. 2009 Jun 13;373(9680):2055-66 - PubMed
  109. Science. 2012 Nov 16;338(6109):949-53 - PubMed
  110. BMC Pharmacol Toxicol. 2016 Nov 2;17 (1):55 - PubMed
  111. Neurotherapeutics. 2015 Apr;12 (2):461-76 - PubMed
  112. Toxicol Lett. 2003 Sep 30;144(2):151-7 - PubMed
  113. Neurotoxicology. 2008 May;29(3):489-503 - PubMed
  114. Chem Res Toxicol. 2010 Feb 15;23(2):319-26 - PubMed
  115. Ann N Y Acad Sci. 2000;920:16-27 - PubMed
  116. Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009399 - PubMed
  117. Biochem Biophys Res Commun. 1980 Feb 12;92(3):1052-69 - PubMed
  118. Exp Biol Med (Maywood). 2006 Oct;231(9):1576-83 - PubMed
  119. J Biol Chem. 1981 Mar 25;256(6):2621-4 - PubMed
  120. J Neurosci. 2004 Dec 8;24(49):11165-70 - PubMed
  121. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7392-6 - PubMed
  122. J Neurol Sci. 2011 Apr 15;303(1-2):95-9 - PubMed
  123. J Neuropathol Exp Neurol. 2013 Feb;72(2):130-6 - PubMed
  124. Neurogenetics. 2011 Nov;12(4):295-305 - PubMed
  125. Neurochem Int. 2014 Jan;65:40-8 - PubMed
  126. Metallomics. 2015 Mar;7(3):395-404 - PubMed
  127. Med Hypotheses. 2006;67(2):251-69 - PubMed
  128. Inorg Chem. 2014 May 5;53(9):4350-8 - PubMed
  129. Mol Neurobiol. 2004 Aug;30(1):1-21 - PubMed
  130. J Neurosci. 2003 Apr 15;23(8):3336-42 - PubMed
  131. Neuron. 2003 Sep 11;39(6):889-909 - PubMed
  132. Physiol Rev. 2007 Jul;87(3):1011-46 - PubMed

Publication Types