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Showing 1 to 12 of 23 entries
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Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.

Frontiers in neuroscience

Okita Y, Rcom-H'cheo-Gauthier AN, Goulding M, Chung RS, Faller P, Pountney DL.
PMID: 28420950
Front Neurosci. 2017 Apr 04;11:114. doi: 10.3389/fnins.2017.00114. eCollection 2017.

Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in...

War, law and humanity, the campaign to control warfare, 1853-1914.

Medicine, conflict, and survival

Pountney M.
PMID: 30231638
Med Confl Surviv. 2018 Sep 19;1-3. doi: 10.1080/13623699.2018.1522769. Epub 2018 Sep 19.

No abstract available.

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia.

Frontiers in cellular neuroscience

Radford RA, Morsch M, Rayner SL, Cole NJ, Pountney DL, Chung RS.
PMID: 26578880
Front Cell Neurosci. 2015 Oct 27;9:414. doi: 10.3389/fncel.2015.00414. eCollection 2015.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two progressive, fatal neurodegenerative syndromes with considerable clinical, genetic and pathological overlap. Clinical symptoms of FTD can be seen in ALS patients and vice versa. Recent genetic discoveries conclusively link...

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease.

Frontiers in neuroscience

Valdinocci D, Simões RF, Kovarova J, Cunha-Oliveira T, Neuzil J, Pountney DL.
PMID: 31619944
Front Neurosci. 2019 Sep 18;13:930. doi: 10.3389/fnins.2019.00930. eCollection 2019.

The appearance of alpha-synuclein-positive inclusion bodies (Lewy bodies) and the loss of catecholaminergic neurons are the primary pathological hallmarks of Parkinson's disease (PD). However, the dysfunction of mitochondria has long been recognized as a key component in the progression...

Blinded reviewing.

Developmental medicine and child neurology

Pountney M.
PMID: 8973290
Dev Med Child Neurol. 1996 Dec;38(12):1059-60.

No abstract available.

Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy.

Cellular and molecular life sciences : CMLS

Raghavan A, Rao P, Neuzil J, Pountney DL, Nath S.
PMID: 34921322
Cell Mol Life Sci. 2021 Dec 18; doi: 10.1007/s00018-021-04040-0. Epub 2021 Dec 18.

Tunnelling nanotubes (TNTs) are an emerging route of long-range intercellular communication that mediate cell-to-cell exchange of cargo and organelles and contribute to maintaining cellular homeostasis by balancing diverse cellular stresses. Besides their role in intercellular communication, TNTs are implicated...

Alpha-Synuclein Aggregates Associated with Mitochondria in Tunnelling Nanotubes.

Neurotoxicity research

Valdinocci D, Kovarova J, Neuzil J, Pountney DL.
PMID: 32926337
Neurotox Res. 2021 Apr;39(2):429-443. doi: 10.1007/s12640-020-00285-y. Epub 2020 Sep 14.

The interaction of α-synuclein with mitochondria in both typical and atypical Parkinson's disease is a critical component of degeneration. The mechanism of cell-to-cell propagation of pathological α-synuclein in synucleinopathies is unclear. Intercellular exchange of mitochondria along tunnelling nanotubes has...

Differential Progression of Motor Dysfunction Between Male and Female Fragile X Premutation Carriers Reveals Novel Aspects of Sex-Specific Neural Involvement.

Frontiers in molecular biosciences

Loesch DZ, Tassone F, Atkinson A, Stimpson P, Trost N, Pountney DL, Storey E.
PMID: 33511153
Front Mol Biosci. 2021 Jan 12;7:577246. doi: 10.3389/fmolb.2020.577246. eCollection 2020.

Expansions of the CGG repeat in the non-coding segment of the FMR1 X-linked gene are associated with a variety of phenotypic changes. Large expansions (>200 repeats), which cause a severe neurodevelopmental disorder, the fragile x syndrome (FXS), are transmitted...

Establishing a therapeutic focus.

The primary care companion for CNS disorders

Schuyler D, Courtney DL.
PMID: 23251864
Prim Care Companion CNS Disord. 2012;14(4). doi: 10.4088/PCC.12f01423. Epub 2012 Aug 02.

No abstract available.

The Lancet, Gaza and academic publishing: defending political engagement.

Medicine, conflict, and survival

Arya N, Birch M, Boulton F, Hodgson S, Holdstock M, Ingram A, Karamoskos P, Kett M, McCoy D, Pountney M, Rushton S, Smith J, van Bergen L, Willis E.
PMID: 26214714
Med Confl Surviv. 2015 Apr-Jun;31(2):81-87. doi: 10.1080/13623699.2015.1050933. Epub 2015 Jul 27.

No abstract available.

A Case of Needle in Foot Revealed by the X Rays.

Bristol medico-chirurgical journal (1883)

Pountney WE.
PMID: 28897233
Bristol Med Chir J (1883). 1896 Sep;14(53):238-239.

No abstract available.

Osteoporosis.

Nursing older people

Pountney D.
PMID: 27726683
Nurs Older People. 2007 Apr 01;19(3):19-21. doi: 10.7748/nop.19.3.19.s16.

It is estimated that one in three women and one in 12 men over the age of 50 suffer from osteoporosis. For women, the one in six lifetime risk of sustaining a hip fracture is greater than the risk...

Showing 1 to 12 of 23 entries