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Fu N, Li L, Yang Q, et al. Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones. Org Lett. 2017;19(8):2122-2125doi: 10.1021/acs.orglett.7b00746.
Fu, N., Li, L., Yang, Q., & Luo, S. (2017). Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones. Organic letters, 19(8), 2122-2125. https://doi.org/10.1021/acs.orglett.7b00746
Fu, Niankai, et al. "Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones." Organic letters vol. 19,8 (2017): 2122-2125. doi: https://doi.org/10.1021/acs.orglett.7b00746
Fu N, Li L, Yang Q, Luo S. Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones. Org Lett. 2017 Apr 21;19(8):2122-2125. doi: 10.1021/acs.orglett.7b00746. Epub 2017 Apr 10. PMID: 28394132.
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Org Lett. 2017 Apr 21;19(8):2122-2125. doi: 10.1021/acs.orglett.7b00746. Epub 2017 Apr 10.

Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones.

Organic letters

Niankai Fu, Longji Li, Qi Yang, Sanzhong Luo

Affiliations

  1. Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
  2. Department of Chemistry, University of Chinese Academy of Sciences , 10049 Beijing, China.
  3. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, China.

PMID: 28394132 DOI: 10.1021/acs.orglett.7b00746

Abstract

Catalytic asymmetric electrochemical C-H functionalization of simple ketones has been developed. The transformation is realized by the combination of electrochemical oxidation and chiral primary amine catalysis. This metal- and oxidant-free method furnishes diverse C1-alkylated tetrahydroisoquinolines in high yields and with excellent enantioselectivities under very mild conditions.

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