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Song L, Xiong D, Song H, et al. Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1-2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens. Front Immunol. 2017;8:326doi: 10.3389/fimmu.2017.00326.
Song, L., Xiong, D., Song, H., Wu, L., Zhang, M., Kang, X., Pan, Z., & Jiao, X. (2017). Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1-2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens. Frontiers in immunology, 8326. https://doi.org/10.3389/fimmu.2017.00326
Song, Li, et al. "Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1-2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens." Frontiers in immunology vol. 8 (2017): 326. doi: https://doi.org/10.3389/fimmu.2017.00326
Song L, Xiong D, Song H, Wu L, Zhang M, Kang X, Pan Z, Jiao X. Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1-2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens. Front Immunol. 2017 Apr 05;8:326. doi: 10.3389/fimmu.2017.00326. eCollection 2017. PMID: 28424686; PMCID: PMC5380672.
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Front Immunol. 2017 Apr 05;8:326. doi: 10.3389/fimmu.2017.00326. eCollection 2017.

Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1-2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens.

Frontiers in immunology

Li Song, Dan Xiong, Hongqin Song, Lili Wu, Meihua Zhang, Xilong Kang, Zhiming Pan, Xinan Jiao

Affiliations

  1. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.
  2. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China.
  3. Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China.
  4. Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou, China.

PMID: 28424686 PMCID: PMC5380672 DOI: 10.3389/fimmu.2017.00326

Abstract

Consecutive cases of human infection with H7N9 influenza viruses since 2013 in China have prompted efforts to develop an effective treatment. Subunit vaccines introduced by intranasal administration can block an infection at its primary site; flagellin (fliC) and polyethyleneimine (PEI) have been shown to be potent adjuvants. We previously generated the hemagglutinin (HA)1-2-fliC fusion protein consisting of the globular head domain (HA1-2; amino acids 62-284) of HA fused with

Keywords: avian influenza A (H7N9) virus; flagellin; hemagglutinin globular head; mucosal subunit vaccine; polyethyleneimine

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