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Zheng C, Lo CY, Meng Z, et al. Gastrodin Inhibits Store-Operated Ca. Front Pharmacol. 2017;8:222doi: 10.3389/fphar.2017.00222.
Zheng, C., Lo, C. Y., Meng, Z., Li, Z., Zhong, M., Zhang, P., Lu, J., Yang, Z., Yan, F., Zhang, Y., Huang, Y., & Yao, X. (2017). Gastrodin Inhibits Store-Operated Ca. Frontiers in pharmacology, 8222. https://doi.org/10.3389/fphar.2017.00222
Zheng, Changbo, et al. "Gastrodin Inhibits Store-Operated Ca." Frontiers in pharmacology vol. 8 (2017): 222. doi: https://doi.org/10.3389/fphar.2017.00222
Zheng C, Lo CY, Meng Z, Li Z, Zhong M, Zhang P, Lu J, Yang Z, Yan F, Zhang Y, Huang Y, Yao X. Gastrodin Inhibits Store-Operated Ca. Front Pharmacol. 2017 Apr 25;8:222. doi: 10.3389/fphar.2017.00222. eCollection 2017. PMID: 28487655; PMCID: PMC5404510.
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Front Pharmacol. 2017 Apr 25;8:222. doi: 10.3389/fphar.2017.00222. eCollection 2017.

Gastrodin Inhibits Store-Operated Ca.

Frontiers in pharmacology

Changbo Zheng, Chun-Yin Lo, Zhaoyue Meng, Zhichao Li, Mingkui Zhong, Peng Zhang, Jun Lu, Zhaoxiang Yang, Fuman Yan, Yunting Zhang, Yu Huang, Xiaoqiang Yao

Affiliations

  1. Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong KongHong Kong, China.
  2. Shenzhen Research Institute, The Chinese University of Hong KongShenzhen, China.
  3. School of Life Sciences, The Chinese University of Hong KongHong Kong, China.
  4. Institute for Drug Research and Development, Kunming Pharmaceutical CorporationKunming, China.

PMID: 28487655 PMCID: PMC5404510 DOI: 10.3389/fphar.2017.00222

Abstract

Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues. In the present study, we examined protective effect of gastrodin against cardiac hypertrophy and explored the underlying mechanism. Phenylephrine and angiotensin II were used to induce cardiac hypertrophy in a mouse model and a cultured cardiomyocyte model. Gastrodin was found to alleviate the cardiac hypertrophy in both models. Mechanistically, gastrodin attenuated the store-operated Ca

Keywords: Orai1; SOCE; STIM1; cardiomyocyte; gastrodin; hypertrophy

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