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Yang Q, Lian Q, Xu F. Perspective: Fabrication of integrated organ-on-a-chip via bioprinting. Biomicrofluidics. 2017;11(3):031301doi: 10.1063/1.4982945.
Yang, Q., Lian, Q., & Xu, F. (2017). Perspective: Fabrication of integrated organ-on-a-chip via bioprinting. Biomicrofluidics, 11(3), 031301. https://doi.org/10.1063/1.4982945
Yang, Qingzhen, et al. "Perspective: Fabrication of integrated organ-on-a-chip via bioprinting." Biomicrofluidics vol. 11,3 (2017): 031301. doi: https://doi.org/10.1063/1.4982945
Yang Q, Lian Q, Xu F. Perspective: Fabrication of integrated organ-on-a-chip via bioprinting. Biomicrofluidics. 2017 May 09;11(3):031301. doi: 10.1063/1.4982945. eCollection 2017 May. PMID: 28529670; PMCID: PMC5423813.
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Biomicrofluidics. 2017 May 09;11(3):031301. doi: 10.1063/1.4982945. eCollection 2017 May.

Perspective: Fabrication of integrated organ-on-a-chip via bioprinting.

Biomicrofluidics

Qingzhen Yang, Qin Lian, Feng Xu

Affiliations

  1. State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, People's Republic of China.

PMID: 28529670 PMCID: PMC5423813 DOI: 10.1063/1.4982945

Abstract

Organ-on-a-chip has emerged as a powerful platform with widespread applications in biomedical engineering, such as pathology studies and drug screening. However, the fabrication of organ-on-a-chip is still a challenging task due to its complexity. For an integrated organ-on-a-chip, it may contain four key elements, i.e., a microfluidic chip, live cells/microtissues that are cultured in this chip, components for stimulus loading to mature the microtissues, and sensors for results readout. Recently, bioprinting has been used for fabricating organ-on-a-chip as it enables the printing of multiple materials, including biocompatible materials and even live cells in a programmable manner with a high spatial resolution. Besides, all four elements for organ-on-a-chip could be printed in a single continuous procedure on one printer; in other words, the fabrication process is assembly free. In this paper, we discuss the recent advances of organ-on-a-chip fabrication by bioprinting. Light is shed on the printing strategies, materials, and biocompatibility. In addition, some specific bioprinted organs-on-chips are analyzed in detail. Because the bioprinted organ-on-a-chip is still in its early stage, significant efforts are still needed. Thus, the challenges presented together with possible solutions and future trends are also discussed.

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