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Rodriguez A, Yokomizo L, Christofferson M, et al. Correlation of rapid point-of-care . World J Gastrointest Pharmacol Ther. 2017;8(2):127-130doi: 10.4292/wjgpt.v8.i2.127.
Rodriguez, A., Yokomizo, L., Christofferson, M., Barnes, D., Khavari, N., & Park, K. T. (2017). Correlation of rapid point-of-care . World journal of gastrointestinal pharmacology and therapeutics, 8(2), 127-130. https://doi.org/10.4292/wjgpt.v8.i2.127
Rodriguez, Alexis, et al. "Correlation of rapid point-of-care ." World journal of gastrointestinal pharmacology and therapeutics vol. 8,2 (2017): 127-130. doi: https://doi.org/10.4292/wjgpt.v8.i2.127
Rodriguez A, Yokomizo L, Christofferson M, Barnes D, Khavari N, Park KT. Correlation of rapid point-of-care . World J Gastrointest Pharmacol Ther. 2017 May 06;8(2):127-130. doi: 10.4292/wjgpt.v8.i2.127. PMID: 28533922; PMCID: PMC5421111.
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World J Gastrointest Pharmacol Ther. 2017 May 06;8(2):127-130. doi: 10.4292/wjgpt.v8.i2.127.

Correlation of rapid point-of-care .

World journal of gastrointestinal pharmacology and therapeutics

Alexis Rodriguez, Lauren Yokomizo, Megan Christofferson, Danielle Barnes, Nasim Khavari, K T Park

Affiliations

  1. Alexis Rodriguez, Lauren Yokomizo, Megan Christofferson, Danielle Barnes, Nasim Khavari, K T Park, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94304, United States.

PMID: 28533922 PMCID: PMC5421111 DOI: 10.4292/wjgpt.v8.i2.127

Abstract

AIM: To assess the correlation between the send-out enzyme-linked immuno sorbent assay (ELISA) and the point-of-care (POC) calprotectin test in pediatric inflammatory bowel disease (IBD) patients.

METHODS: We prospectively collected stool samples in pediatric IBD patients for concomitant send-out ELISA analysis and POC calprotectin testing using the Quantum Blue

RESULTS: Forty-nine stool samples were collected from 31 pediatric IBD patients. The overall means for the rapid and ELISA tests were 580.5 and 522.87 μg/g respectively. Among the 49 samples, 18 (37.5%) had POC calprotectin levels of ≤ 250 μg/g and 31 (62.5%) had levels > 250 μg/g. Calprotectin levels ≤ 250 μg/g show good correlation between the two assays. Less correlation was observed at quantitatively higher calprotectin levels.

CONCLUSION: In pediatric IBD patients, there is better correlation of between ELISA and POC calprotectin measurements at clinically meaningful, low-range levels. Future adoption of POC calprotectin testing in the United States may have utility for guiding clinical decision making in real time.

Keywords: Calprotectin; Crohn’s disease; Inflammatory bowel disease; Point-of-care test; Stool biomarker; Ulcerative colitis

Conflict of interest statement

Conflict-of-interest statement: K T Park has served as consultant for Inova Diagnostics and received research support from BUHL MANN Laboratories.

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