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Hu T, Yang C, Fu M, et al. Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change. Regen Biomater. 2017;4(3):167-178doi: 10.1093/rb/rbx010.
Hu, T., Yang, C., Fu, M., Yang, J., Du, R., Ran, X., Yin, T., & Wang, G. (2017). Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change. Regenerative biomaterials, 4(3), 167-178. https://doi.org/10.1093/rb/rbx010
Hu, Tingzhang, et al. "Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change." Regenerative biomaterials vol. 4,3 (2017): 167-178. doi: https://doi.org/10.1093/rb/rbx010
Hu T, Yang C, Fu M, Yang J, Du R, Ran X, Yin T, Wang G. Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change. Regen Biomater. 2017 Jun;4(3):167-178. doi: 10.1093/rb/rbx010. Epub 2017 May 05. PMID: 28596914; PMCID: PMC5458539.
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Regen Biomater. 2017 Jun;4(3):167-178. doi: 10.1093/rb/rbx010. Epub 2017 May 05.

Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change.

Regenerative biomaterials

Tingzhang Hu, Chun Yang, Meiling Fu, Jiali Yang, Rolin Du, Xiaolin Ran, Tieying Yin, Guixue Wang

Affiliations

  1. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China.

PMID: 28596914 PMCID: PMC5458539 DOI: 10.1093/rb/rbx010

Abstract

Docetaxel (DTX), a paclitaxel analogue, can efficiently inhibit proliferation of vascular smooth muscle cells and has broadly been used as an antiangiogenesis drug. However, as a candidate drug of drug-eluting stent, the effects of DTX on human umbilical vein endothelial cells (HUVECs) are still not well understood. Herein, we investigated the effects of DTX on proliferation, apoptosis, adhesion, migration and morphology of HUVECs

Keywords: cytotoxic effects; docetaxel; endothelial cells; signaling pathway

References

  1. Int J Clin Exp Pathol. 2015 Aug 01;8(8):9072-80 - PubMed
  2. Curr Opin Cell Biol. 2007 Feb;19(1):43-50 - PubMed
  3. J Biomed Mater Res B Appl Biomater. 2006 Jan;76(1):49-55 - PubMed
  4. Nat Med. 2002 Nov;8(11):1249-56 - PubMed
  5. Circulation. 2009 Aug 4;120(5):391-9 - PubMed
  6. J Histochem Cytochem. 2014 Mar;62(3):172-84 - PubMed
  7. Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):301-16 - PubMed
  8. Drug Des Devel Ther. 2012;6:371-84 - PubMed
  9. Cancer Res. 2006 Aug 15;66(16):8192-9 - PubMed
  10. J Am Coll Cardiol. 2008 Jul 29;52(5):333-42 - PubMed
  11. Exp Hematol. 2010 Sep;38(9):733-43 - PubMed
  12. Exp Cell Res. 2013 Apr 15;319(7):982-91 - PubMed
  13. J Pharmacol Sci. 2011;116(2):204-13 - PubMed
  14. Int J Pharm. 2013 Jan 30;441(1-2):665-79 - PubMed
  15. Nat Rev Cardiol. 2013 Feb;10(2):59 - PubMed
  16. J Cell Sci. 2008 Jul 1;121(Pt 13):2115-22 - PubMed
  17. Toxicol Sci. 2015 May;145(1):59-67 - PubMed
  18. Regen Biomater. 2015 Jun;2(2):87-96 - PubMed
  19. J Cell Biochem. 2003 Sep 1;90(1):121-37 - PubMed
  20. Regen Biomater. 2014 Nov;1(1):49-55 - PubMed
  21. Biochem Pharmacol. 2009 Nov 1;78(9):1167-77 - PubMed
  22. Anticancer Drugs. 2014 May;25(5):488-94 - PubMed
  23. J Biomed Mater Res A. 2014 May;102(5):1625-40 - PubMed
  24. Genet Mol Res. 2016 Feb 05;15(1):null - PubMed
  25. ACS Appl Mater Interfaces. 2015 Jun 10;7(22):11695-712 - PubMed
  26. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68 - PubMed
  27. Cytoskeleton (Hoboken). 2014 Jan;71(1):46-60 - PubMed
  28. J Ethnopharmacol. 2009 Dec 10;126(3):463-7 - PubMed
  29. Eur J Cardiovasc Nurs. 2011 Jul;10 Suppl 2:S5-13 - PubMed
  30. Biochem Pharmacol. 2008 Mar 15;75(6):1331-40 - PubMed
  31. J R Soc Interface. 2011 Oct 7;8(63):1379-85 - PubMed
  32. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):133-41 - PubMed
  33. Neuro Oncol. 2009 Jun;11(3):260-73 - PubMed
  34. Angiogenesis. 2013 Jul;16(3):481-92 - PubMed
  35. Cell Physiol Biochem. 2014;33(6):1888-98 - PubMed
  36. Regen Biomater. 2016 Sep;3(3):167-71 - PubMed
  37. Mol Cancer Ther. 2006 Sep;5(9):2348-57 - PubMed
  38. Cancer Res. 2005 Mar 15;65(6):2433-40 - PubMed
  39. ACS Appl Mater Interfaces. 2013 Jun 12;5(11):5112-21 - PubMed
  40. Cell Tissue Res. 2014 Mar;355(3):515-22 - PubMed
  41. J Biomed Mater Res A. 2015 Dec;103(12):3993-4023 - PubMed

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