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Yang J, Sun L, Wang L, et al. Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats. Front Pharmacol. 2017;8:260doi: 10.3389/fphar.2017.00260.
Yang, J., Sun, L., Wang, L., Hassan, H. M., Wang, X., Hylemon, P. B., Wang, T., Zhou, H., Zhang, L., & Jiang, Z. (2017). Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats. Frontiers in pharmacology, 8260. https://doi.org/10.3389/fphar.2017.00260
Yang, Jing, et al. "Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats." Frontiers in pharmacology vol. 8 (2017): 260. doi: https://doi.org/10.3389/fphar.2017.00260
Yang J, Sun L, Wang L, Hassan HM, Wang X, Hylemon PB, Wang T, Zhou H, Zhang L, Jiang Z. Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats. Front Pharmacol. 2017 May 09;8:260. doi: 10.3389/fphar.2017.00260. eCollection 2017. PMID: 28536529; PMCID: PMC5422577.
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Front Pharmacol. 2017 May 09;8:260. doi: 10.3389/fphar.2017.00260. eCollection 2017.

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats.

Frontiers in pharmacology

Jing Yang, Lixin Sun, Lu Wang, Hozeifa M Hassan, Xuan Wang, Phillip B Hylemon, Tao Wang, Huiping Zhou, Luyong Zhang, Zhenzhou Jiang

Affiliations

  1. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical UniversityNanjing, China.
  2. Department of Microbiology and Immunology, Virginia Commonwealth University, RichmondVA, USA.
  3. McGuire Veterans Affairs Medical Center, RichmondVA, USA.
  4. Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical UniversityNanjing, China.
  5. State Key Laboratory of Natural Medicines, China Pharmaceutical UniversityNanjing, China.
  6. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of EducationNanjing, China.
  7. Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical UniversityNanjing, China.

PMID: 28536529 PMCID: PMC5422577 DOI: 10.3389/fphar.2017.00260

Abstract

Triptolide (TP), a diterpenoid isolated from

Keywords: Sirtuin 1; bile acid metabolism; farnesoid X receptor; hepatic gluconeogenesis; hepatotoxicity; triptolide

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