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Nwabo Kamdje AH, Kamga PT, Simo RT, et al. Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer Biol Med. 2017;14(2):129-141doi: 10.20892/j.issn.2095-3941.2016.0033.
Nwabo Kamdje, A. H., Kamga, P. T., Simo, R. T., Vecchio, L., Seke Etet, P. F., Muller, J. M., Bassi, G., Lukong, E., Goel, R. K., Amvene, J. M., & Krampera, M. (2017). Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer biology & medicine, 14(2), 129-141. https://doi.org/10.20892/j.issn.2095-3941.2016.0033
Nwabo Kamdje, Armel Herve, et al. "Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways." Cancer biology & medicine vol. 14,2 (2017): 129-141. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0033
Nwabo Kamdje AH, Kamga PT, Simo RT, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Goel RK, Amvene JM, Krampera M. Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer Biol Med. 2017 May;14(2):129-141. doi: 10.20892/j.issn.2095-3941.2016.0033. PMID: 28607804; PMCID: PMC5444925.
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Cancer Biol Med. 2017 May;14(2):129-141. doi: 10.20892/j.issn.2095-3941.2016.0033.

Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways.

Cancer biology & medicine

Armel Herve Nwabo Kamdje, Paul Takam Kamga, Richard Tagne Simo, Lorella Vecchio, Paul Faustin Seke Etet, Jean Marc Muller, Giulio Bassi, Erique Lukong, Raghuveera Kumar Goel, Jeremie Mbo Amvene, Mauro Krampera

Affiliations

  1. Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere 454, Cameroon.

PMID: 28607804 PMCID: PMC5444925 DOI: 10.20892/j.issn.2095-3941.2016.0033

Abstract

Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like " wounds that do not heal." In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed.

Keywords: Mesenchymal stromal cells; chemoresistance; homing; migration; signaling pathways; systemic circulation; tumor modulation

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