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Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways.

Cancer biology & medicine

Nwabo Kamdje AH, Kamga PT, Simo RT, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Goel RK, Amvene JM, Krampera M.
PMID: 28607804
Cancer Biol Med. 2017 May;14(2):129-141. doi: 10.20892/j.issn.2095-3941.2016.0033.

Mesenchymal stromal cells (MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites...

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Nwabo Kamdje AH, Kamga PT, Simo RT, et al. Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer Biol Med. 2017;14(2):129-141doi: 10.20892/j.issn.2095-3941.2016.0033.
Nwabo Kamdje, A. H., Kamga, P. T., Simo, R. T., Vecchio, L., Seke Etet, P. F., Muller, J. M., Bassi, G., Lukong, E., Goel, R. K., Amvene, J. M., & Krampera, M. (2017). Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer biology & medicine, 14(2), 129-141. https://doi.org/10.20892/j.issn.2095-3941.2016.0033
Nwabo Kamdje, Armel Herve, et al. "Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways." Cancer biology & medicine vol. 14,2 (2017): 129-141. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0033
Nwabo Kamdje AH, Kamga PT, Simo RT, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Goel RK, Amvene JM, Krampera M. Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer Biol Med. 2017 May;14(2):129-141. doi: 10.20892/j.issn.2095-3941.2016.0033. PMID: 28607804; PMCID: PMC5444925.
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Methylation Dynamics of .

Cancers

Malpeli G, Innamorati G, Decimo I, Bencivenga M, Nwabo Kamdje AH, Perris R, Bassi C.
PMID: 31323949
Cancers (Basel). 2019 Jul 09;11(7). doi: 10.3390/cancers11070959.

5-methyl cytosine (5mC) is a key epigenetic mark entwined with gene expression and the specification of cellular phenotypes. Its distribution around gene promoters sets a barrier for transcriptional enhancers or inhibitor proteins binding to their target sequences. As a...

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Malpeli G, Innamorati G, Decimo I, et al. Methylation Dynamics of . Cancers (Basel). 2019;11(7)doi: 10.3390/cancers11070959.
Malpeli, G., Innamorati, G., Decimo, I., Bencivenga, M., Nwabo Kamdje, A. H., Perris, R., & Bassi, C. (2019). Methylation Dynamics of . Cancers, 11(7), . https://doi.org/10.3390/cancers11070959
Malpeli, Giorgio, et al. "Methylation Dynamics of ." Cancers vol. 11,7 (2019). doi: https://doi.org/10.3390/cancers11070959
Malpeli G, Innamorati G, Decimo I, Bencivenga M, Nwabo Kamdje AH, Perris R, Bassi C. Methylation Dynamics of . Cancers (Basel). 2019 Jul 09;11(7). doi: 10.3390/cancers11070959. PMID: 31323949; PMCID: PMC6678546.
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Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects.

Frontiers in cell and developmental biology

Nwabo Kamdje AH, Seke Etet PF, Simo Tagne R, Vecchio L, Lukong KE, Krampera M.
PMID: 33330442
Front Cell Dev Biol. 2020 Nov 19;8:545126. doi: 10.3389/fcell.2020.545126. eCollection 2020.

The role of mesenchymal stromal cells (MSCs) in the tumor microenvironment is well described. Available data support that MSCs display anticancer activities, and that their reprogramming by cancer cells in the tumor microenvironment induces their switch toward pro-tumorigenic activities....

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Nwabo Kamdje AH, Seke Etet PF, Simo Tagne R, et al. Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects. Front Cell Dev Biol. 2020;8:545126doi: 10.3389/fcell.2020.545126.
Nwabo Kamdje, A. H., Seke Etet, P. F., Simo Tagne, R., Vecchio, L., Lukong, K. E., & Krampera, M. (2020). Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects. Frontiers in cell and developmental biology, 8545126. https://doi.org/10.3389/fcell.2020.545126
Nwabo Kamdje, Armel H, et al. "Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects." Frontiers in cell and developmental biology vol. 8 (2020): 545126. doi: https://doi.org/10.3389/fcell.2020.545126
Nwabo Kamdje AH, Seke Etet PF, Simo Tagne R, Vecchio L, Lukong KE, Krampera M. Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects. Front Cell Dev Biol. 2020 Nov 19;8:545126. doi: 10.3389/fcell.2020.545126. eCollection 2020. PMID: 33330442; PMCID: PMC7710932.
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Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon.

International journal of breast cancer

Tagne Simo R, Baiguerel EM, Nwabo Kamdje AH, Seke Etet PF, Ahmadou M, Nangue C, Telefo PB.
PMID: 34354843
Int J Breast Cancer. 2021 Jul 27;2021:6663195. doi: 10.1155/2021/6663195. eCollection 2021.

Breast cancer has become a real public health problem in Cameroon, particularly in rural areas due to late diagnosis, resulting partly from the absence of national screening programs. This work is aimed at assessing breast cancer awareness in the...

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Tagne Simo R, Baiguerel EM, Nwabo Kamdje AH, et al. Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon. Int J Breast Cancer. 2021;2021:6663195doi: 10.1155/2021/6663195.
Tagne Simo, R., Baiguerel, E. M., Nwabo Kamdje, A. H., Seke Etet, P. F., Ahmadou, M., Nangue, C., & Telefo, P. B. (2021). Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon. International journal of breast cancer, 20216663195. https://doi.org/10.1155/2021/6663195
Tagne Simo, Richard, et al. "Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon." International journal of breast cancer vol. 2021 (2021): 6663195. doi: https://doi.org/10.1155/2021/6663195
Tagne Simo R, Baiguerel EM, Nwabo Kamdje AH, Seke Etet PF, Ahmadou M, Nangue C, Telefo PB. Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon. Int J Breast Cancer. 2021 Jul 27;2021:6663195. doi: 10.1155/2021/6663195. eCollection 2021. PMID: 34354843; PMCID: PMC8331314.
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Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog.

Cancer biology & medicine

Nwabo Kamdje AH, Takam Kamga P, Tagne Simo R, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Kumar Goel R, Mbo Amvene J, Krampera M.
PMID: 28607802
Cancer Biol Med. 2017 May;14(2):109-120. doi: 10.20892/j.issn.2095-3941.2016.0032.

Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death, motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer...

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Nwabo Kamdje AH, Takam Kamga P, Tagne Simo R, et al. Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog. Cancer Biol Med. 2017;14(2):109-120doi: 10.20892/j.issn.2095-3941.2016.0032.
Nwabo Kamdje, A. H., Takam Kamga, P., Tagne Simo, R., Vecchio, L., Seke Etet, P. F., Muller, J. M., Bassi, G., Lukong, E., Kumar Goel, R., Mbo Amvene, J., & Krampera, M. (2017). Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog. Cancer biology & medicine, 14(2), 109-120. https://doi.org/10.20892/j.issn.2095-3941.2016.0032
Nwabo Kamdje, Armel Herve, et al. "Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog." Cancer biology & medicine vol. 14,2 (2017): 109-120. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0032
Nwabo Kamdje AH, Takam Kamga P, Tagne Simo R, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Kumar Goel R, Mbo Amvene J, Krampera M. Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog. Cancer Biol Med. 2017 May;14(2):109-120. doi: 10.20892/j.issn.2095-3941.2016.0032. PMID: 28607802; PMCID: PMC5444923.
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Breast cancer awareness and screening practice amongst health personnel and general population of the littoral region of Cameroon.

Heliyon

Halmata M, Simo Tagne R, Nganwa Kembaou G, Baiguerel EM, Ndopwang LCC, Nwabo Kamdje AH, Telefo PB, Nangue C, Nchiwan Nukenine E.
PMID: 34345730
Heliyon. 2021 Jul 09;7(7):e07534. doi: 10.1016/j.heliyon.2021.e07534. eCollection 2021 Jul.

INTRODUCTION: Late diagnosis has been observed as the hallmark of breast cancer in Cameroonian women where over 70% of patients report with either stage III or IV of the disease, with high mortality and dire socioeconomic consequences. The present...

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Halmata M, Simo Tagne R, Nganwa Kembaou G, et al. Breast cancer awareness and screening practice amongst health personnel and general population of the littoral region of Cameroon. Heliyon. 2021;7(7):e07534doi: 10.1016/j.heliyon.2021.e07534.
Halmata, M., Simo Tagne, R., Nganwa Kembaou, G., Baiguerel, E. M., Ndopwang, L. C. C., Nwabo Kamdje, A. H., Telefo, P. B., Nangue, C., & Nchiwan Nukenine, E. (2021). Breast cancer awareness and screening practice amongst health personnel and general population of the littoral region of Cameroon. Heliyon, 7(7), e07534. https://doi.org/10.1016/j.heliyon.2021.e07534
Halmata, Mohamadou, et al. "Breast cancer awareness and screening practice amongst health personnel and general population of the littoral region of Cameroon." Heliyon vol. 7,7 (2021): e07534. doi: https://doi.org/10.1016/j.heliyon.2021.e07534
Halmata M, Simo Tagne R, Nganwa Kembaou G, Baiguerel EM, Ndopwang LCC, Nwabo Kamdje AH, Telefo PB, Nangue C, Nchiwan Nukenine E. Breast cancer awareness and screening practice amongst health personnel and general population of the littoral region of Cameroon. Heliyon. 2021 Jul 09;7(7):e07534. doi: 10.1016/j.heliyon.2021.e07534. eCollection 2021 Jul. PMID: 34345730; PMCID: PMC8319513.
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Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy.

Blood cancer journal

Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G, Krampera M.
PMID: 22829975
Blood Cancer J. 2012 May;2(5):e73. doi: 10.1038/bcj.2012.17. Epub 2012 May 25.

Stromal cells are essential components of the bone marrow (BM) microenvironment that regulate and support the survival of different tumors, including chronic lymphocytic leukemia (CLL). In this study, we investigated the role of Notch signaling in the promotion of...

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Nwabo Kamdje AH, Bassi G, Pacelli L, et al. Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Blood Cancer J. 2012;2(5):e73doi: 10.1038/bcj.2012.17.
Nwabo Kamdje, A. H., Bassi, G., Pacelli, L., Malpeli, G., Amati, E., Nichele, I., Pizzolo, G., & Krampera, M. (2012). Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Blood cancer journal, 2(5), e73. https://doi.org/10.1038/bcj.2012.17
Nwabo Kamdje, A H, et al. "Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy." Blood cancer journal vol. 2,5 (2012): e73. doi: https://doi.org/10.1038/bcj.2012.17
Nwabo Kamdje AH, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, Pizzolo G, Krampera M. Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Blood Cancer J. 2012 May;2(5):e73. doi: 10.1038/bcj.2012.17. Epub 2012 May 25. PMID: 22829975; PMCID: PMC3366070.
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New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers.

World journal of clinical cases

Nwabo Kamdje AH, Seke Etet PF, Vecchio L, Tagne RS, Amvene JM, Muller JM, Krampera M, Lukong KE.
PMID: 25516852
World J Clin Cases. 2014 Dec 16;2(12):769-86. doi: 10.12998/wjcc.v2.i12.769.

Breast cancer is the most frequent female malignancy worldwide. Current strategies in breast cancer therapy, including classical chemotherapy, hormone therapy, and targeted therapies, are usually associated with chemoresistance and serious adverse effects. Advances in our understanding of changes affecting...

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Nwabo Kamdje AH, Seke Etet PF, Vecchio L, et al. New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers. World J Clin Cases. 2014;2(12):769-86doi: 10.12998/wjcc.v2.i12.769.
Nwabo Kamdje, A. H., Seke Etet, P. F., Vecchio, L., Tagne, R. S., Amvene, J. M., Muller, J. M., Krampera, M., & Lukong, K. E. (2014). New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers. World journal of clinical cases, 2(12), 769-86. https://doi.org/10.12998/wjcc.v2.i12.769
Nwabo Kamdje, Armel Hervé, et al. "New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers." World journal of clinical cases vol. 2,12 (2014): 769-86. doi: https://doi.org/10.12998/wjcc.v2.i12.769
Nwabo Kamdje AH, Seke Etet PF, Vecchio L, Tagne RS, Amvene JM, Muller JM, Krampera M, Lukong KE. New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers. World J Clin Cases. 2014 Dec 16;2(12):769-86. doi: 10.12998/wjcc.v2.i12.769. PMID: 25516852; PMCID: PMC4266825.
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Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants.

Asian Pacific journal of tropical medicine

Tagne RS, Telefo BP, Nyemb JN, Yemele DM, Njina SN, Goka SM, Lienou LL, Nwabo Kamdje AH, Moundipa PF, Farooq AD.
PMID: 25312165
Asian Pac J Trop Med. 2014 Sep;7:S442-7. doi: 10.1016/S1995-7645(14)60272-8.

OBJECTIVE: To obtain a scientific basis of the use of plant-derived preparations by many rural people in Cameroon, for their primary health care needs in the treatment of diseases such as cancer.METHODS: The antiproliferative effect of 11 plants methanol...

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Tagne RS, Telefo BP, Nyemb JN, et al. Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants. Asian Pac J Trop Med. 2014;7:S442-7doi: 10.1016/S1995-7645(14)60272-8.
Tagne, R. S., Telefo, B. P., Nyemb, J. N., Yemele, D. M., Njina, S. N., Goka, S. M., Lienou, L. L., Nwabo Kamdje, A. H., Moundipa, P. F., & Farooq, A. D. (2014). Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants. Asian Pacific journal of tropical medicine, 7S442-7. https://doi.org/10.1016/S1995-7645(14)60272-8
Tagne, Richard Simo, et al. "Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants." Asian Pacific journal of tropical medicine vol. 7 (2014): S442-7. doi: https://doi.org/10.1016/S1995-7645(14)60272-8
Tagne RS, Telefo BP, Nyemb JN, Yemele DM, Njina SN, Goka SM, Lienou LL, Nwabo Kamdje AH, Moundipa PF, Farooq AD. Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants. Asian Pac J Trop Med. 2014 Sep;7:S442-7. doi: 10.1016/S1995-7645(14)60272-8. PMID: 25312165.
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