Display options
Cite
Youssef AA, Ross EG, Bolli R, et al. The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC Basic Transl Sci. 2016;1(6):510-523doi: 10.1016/j.jacbts.2016.06.010.
Youssef, A. A., Ross, E. G., Bolli, R., Pepine, C. J., Leeper, N. J., & Yang, P. C. (2016). The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC. Basic to translational science, 1(6), 510-523. https://doi.org/10.1016/j.jacbts.2016.06.010
Youssef, Amr A, et al. "The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications." JACC. Basic to translational science vol. 1,6 (2016): 510-523. doi: https://doi.org/10.1016/j.jacbts.2016.06.010
Youssef AA, Ross EG, Bolli R, Pepine CJ, Leeper NJ, Yang PC. The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC Basic Transl Sci. 2016 Oct;1(6):510-523. doi: 10.1016/j.jacbts.2016.06.010. PMID: 28580434; PMCID: PMC5451899.
Copy Download .nbib Format: NLM
Share it on

JACC Basic Transl Sci. 2016 Oct;1(6):510-523. doi: 10.1016/j.jacbts.2016.06.010.

The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications.

JACC. Basic to translational science

Amr A Youssef, Elsie Gyang Ross, Roberto Bolli, Carl J Pepine, Nicholas J Leeper, Phillip C Yang

Affiliations

  1. Division of Cardiology, Ain Shams University, Cairo, Egypt and Aurora Bay Area Medical Center, Marinette, Wisconsin, USA.
  2. Division of Cardiovascular Medicine and Vascular Surgery, Stanford University, California, USA.
  3. Division of Cardiovascular Medicine, University of Louisville, Louisville, Kentucky, USA.
  4. Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
  5. Division of Cardiovascular Medicine, Stanford University, California, USA.

PMID: 28580434 PMCID: PMC5451899 DOI: 10.1016/j.jacbts.2016.06.010

Abstract

The recent discovery of human-induced pluripotent stem cells (iPSCs) has revolutionized the field of stem cells. iPSCs have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected to advance our current understanding of many disease processes and revolutionize the approach to effective therapeutics. Despite the great promise of iPSCs, many translational challenges still remain. In this article, we review the basic concept of induction of pluripotency as a novel approach to understand cardiac regeneration, cardiovascular disease modeling and drug discovery. We critically reflect on the current results of preclinical and clinical studies using iPSCs for these applications with appropriate emphasis on the challenges facing clinical translation.

Keywords: Cardiac regeneration; Disease modeling; Drug discovery; Induced pluripotent stem cells

References

  1. Nature. 2007 Jul 19;448(7151):318-24 - PubMed
  2. Nature. 2011 May 13;474(7350):212-5 - PubMed
  3. J Cell Mol Med. 2012 Mar;16(3):468-82 - PubMed
  4. N Engl J Med. 2002 Jan 3;346(1):5-15 - PubMed
  5. Nat Biotechnol. 2008 Jan;26(1):101-6 - PubMed
  6. Nature. 2008 Jan 10;451(7175):141-6 - PubMed
  7. Cell Stem Cell. 2011 Feb 4;8(2):228-40 - PubMed
  8. Lab Chip. 2011 Dec 21;11(24):4165-73 - PubMed
  9. Sci Transl Med. 2014 Jun 11;6(240):240ra74 - PubMed
  10. Am Heart J. 2014 Nov;168(5):667-73 - PubMed
  11. Nature. 2013 Feb 7;494(7435):100-4 - PubMed
  12. Eur Heart J. 2011 Nov;32(21):2634-41 - PubMed
  13. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14234-9 - PubMed
  14. Curr Biol. 2001 Oct 2;11(19):1553-8 - PubMed
  15. PLoS One. 2010 Jun 29;5(6):e11373 - PubMed
  16. Nat Methods. 2011 May;8(5):409-12 - PubMed
  17. Circulation. 2009 Aug 4;120(5):408-16 - PubMed
  18. Cardiovasc Res. 2008 May 1;78(2):265-73 - PubMed
  19. Nature. 2011 Mar 3;471(7336):58-62 - PubMed
  20. Sci Transl Med. 2012 Apr 18;4(130):130ra47 - PubMed
  21. EMBO Mol Med. 2012 Mar;4(3):180-91 - PubMed
  22. Hum Mol Genet. 2011 Dec 15;20(24):4851-64 - PubMed
  23. PLoS One. 2011;6(8):e23657 - PubMed
  24. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16772-7 - PubMed
  25. Nature. 2007 Jul 19;448(7151):313-7 - PubMed
  26. Cell Stem Cell. 2011 Jan 7;8(1):106-18 - PubMed
  27. Int J Cardiol. 2015 Oct 15;197:116-22 - PubMed
  28. J Thorac Cardiovasc Surg. 2008 Oct;136(4):1028-1037.e1 - PubMed
  29. Circ Res. 1999 Aug 6;85(3):221-8 - PubMed
  30. Cell Stem Cell. 2012 Aug 3;11(2):147-52 - PubMed
  31. Science. 1997 Feb 14;275(5302):964-7 - PubMed
  32. Biomaterials. 2014 Oct;35(32):8960-9 - PubMed
  33. Science. 1998 Nov 6;282(5391):1145-7 - PubMed
  34. PLoS One. 2011 Apr 28;6(4):e19012 - PubMed
  35. Science. 2009 Apr 3;324(5923):98-102 - PubMed
  36. N Engl J Med. 2000 Oct 12;343(15):1078-84 - PubMed
  37. Cell. 2014 Mar 27;157(1):110-9 - PubMed
  38. Lab Chip. 2013 Sep 21;13(18):3599-608 - PubMed
  39. Nature. 2011 Mar 10;471(7337):225-9 - PubMed
  40. Blood. 2009 May 28;113(22):5476-9 - PubMed
  41. Nature. 2010 Jun 10;465(7299):808-12 - PubMed
  42. Magn Reson Med. 2006 Jan;55(1):203-9 - PubMed
  43. Cell Stem Cell. 2013 Apr 4;12(4):407-12 - PubMed
  44. Stem Cells. 2009 Mar;27(3):559-67 - PubMed
  45. PLoS One. 2011;6(8):e23667 - PubMed
  46. Toxicol Sci. 2013 Dec;136(2):581-94 - PubMed
  47. J Am Coll Cardiol. 2011 Nov 8;58(20):2118-27 - PubMed
  48. Stem Cells Dev. 2012 Oct 10;21(15):2798-808 - PubMed
  49. Circulation. 2013 Mar 5;127(9):997-1008 - PubMed
  50. PLoS One. 2015 May 13;10(5):e0126596 - PubMed
  51. PLoS One. 2015 Mar 23;10(3):e0120585 - PubMed
  52. Circulation. 2015 Jan 20;131(3):300-9 - PubMed
  53. Cell. 2010 Aug 6;142(3):375-86 - PubMed
  54. Science. 2012 Nov 30;338(6111):1155-6 - PubMed
  55. Cell. 2006 Aug 25;126(4):663-76 - PubMed
  56. Circulation. 2012 Oct 2;126(14):1695-704 - PubMed
  57. Proc Natl Acad Sci U S A. 1952 May;38(5):455-63 - PubMed
  58. J Am Coll Cardiol. 2012 Sep 11;60(11):990-1000 - PubMed
  59. Nat Methods. 2011 Mar;8(3):242-5 - PubMed
  60. Basic Res Cardiol. 2012 Nov;107(6):301 - PubMed
  61. Nat Biotechnol. 2014 Aug;32(8):760-72 - PubMed
  62. Circ Res. 2011 Jun 24;109(1):60-70 - PubMed
  63. Circ Res. 2015 Mar 27;116(7):1216-30 - PubMed
  64. Eur Heart J. 2013 Apr;34(15):1122-33 - PubMed
  65. N Engl J Med. 2010 Oct 7;363(15):1397-409 - PubMed
  66. Nat Protoc. 2012 Dec;7(12):2080-9 - PubMed
  67. Circulation. 2008 Jul 29;118(5):498-506 - PubMed
  68. Nature. 2013 Feb 28;494(7438):413 - PubMed
  69. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8801-5 - PubMed
  70. Science. 2007 Dec 21;318(5858):1917-20 - PubMed
  71. Stem Cell Reports. 2013 Jul 25;1(2):105-13 - PubMed
  72. Curr Opin Genet Dev. 2015 Oct;34:77-81 - PubMed
  73. Circ Res. 2014 Apr 11;114(8):1328-45 - PubMed
  74. Regen Med. 2011 Mar;6(2):171-8 - PubMed
  75. Dis Model Mech. 2013 May;6(3):608-21 - PubMed
  76. Am J Transl Res. 2013;5(1):21-35 - PubMed
  77. Ann Thorac Surg. 2014 Sep;98(3):947-54 - PubMed
  78. Nature. 2006 Jul 27;442(7101):381-6 - PubMed
  79. PLoS One. 2013 Jun 21;8(6):e66688 - PubMed
  80. Nature. 2006 Jun 29;441(7097):1061-7 - PubMed
  81. FASEB J. 2007 May;21(7):1345-57 - PubMed
  82. J Am Coll Cardiol. 2009 Apr 7;53(14):1229-40 - PubMed
  83. Nat Commun. 2014 May 30;5:3903 - PubMed
  84. PLoS One. 2012;7(9):e44660 - PubMed
  85. Cell Stem Cell. 2013 Jan 3;12(1):101-13 - PubMed
  86. Cell Stem Cell. 2013 Oct 3;13(4):382-4 - PubMed
  87. Methodist Debakey Cardiovasc J. 2013 Oct-Dec;9(4):201-5 - PubMed
  88. Nat Med. 2014 Jun;20(6):616-23 - PubMed
  89. Nature. 2014 May 15;509(7500):337-41 - PubMed
  90. Nat Chem Biol. 2013 Apr;9(4):232-40 - PubMed
  91. Circ Res. 2004 Oct 29;95(9):911-21 - PubMed
  92. Circulation. 2012 Sep 11;126(11 Suppl 1):S29-37 - PubMed
  93. Nat Protoc. 2013 Jan;8(1):162-75 - PubMed
  94. Nat Med. 2013 Aug;19(8):998-1004 - PubMed
  95. Circulation. 2010 Aug 3;122(5):517-26 - PubMed
  96. Cell. 2012 Oct 26;151(3):547-58 - PubMed
  97. Science. 1980 Apr 11;208(4440):179-81 - PubMed
  98. Nature. 2012 May 31;485(7400):593-8 - PubMed
  99. Science. 2005 Aug 26;309(5739):1369-73 - PubMed
  100. N Engl J Med. 2001 Jun 7;344(23):1750-7 - PubMed
  101. Cell Stem Cell. 2009 Oct 2;5(4):353-7 - PubMed
  102. Nature. 2013 Feb 7;494(7435):105-10 - PubMed
  103. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15720-5 - PubMed
  104. Nature. 2009 Oct 1;461(7264):649-3 - PubMed
  105. Nat Biotechnol. 2008 Nov;26(11):1276-84 - PubMed
  106. Circulation. 2008 Jul 29;118(5):507-17 - PubMed
  107. Circulation. 2013 Sep 10;128(11 Suppl 1):S3-13 - PubMed
  108. Stem Cells. 2012 Feb;30(2):180-6 - PubMed
  109. Stem Cells Transl Med. 2014 Apr;3(4):416-23 - PubMed
  110. Nature. 2001 Apr 5;410(6829):701-5 - PubMed
  111. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12704-9 - PubMed
  112. Dis Model Mech. 2012 Mar;5(2):220-30 - PubMed
  113. Am J Physiol Cell Physiol. 2004 Sep;287(3):C572-9 - PubMed
  114. Nature. 2011 Mar 3;471(7336):68-73 - PubMed
  115. Science. 1999 Apr 2;284(5411):143-7 - PubMed
  116. Circ Res. 2015 Mar 27;116(7):e40-50 - PubMed
  117. Cell. 2007 Nov 30;131(5):861-72 - PubMed
  118. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13793-8 - PubMed
  119. PLoS One. 2013;8(3):e57876 - PubMed
  120. Stem Cells Transl Med. 2014 Apr;3(4):500-9 - PubMed
  121. Nature. 2010 Sep 16;467(7313):285-90 - PubMed
  122. Eur Heart J. 2011 Apr;32(8):952-62 - PubMed
  123. Nat Biotechnol. 2015 Jan;33(1):58-63 - PubMed
  124. Nature. 2012 Jan 18;481(7381):295-305 - PubMed
  125. Circ Cardiovasc Imaging. 2008 Jul;1(1):6-13 - PubMed
  126. Nature. 2012 May 13;485(7400):599-604 - PubMed
  127. Nat Methods. 2014 Aug;11(8):855-60 - PubMed
  128. Circ Res. 2012 Jun 22;111(1):3-4 - PubMed
  129. Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1100-3 - PubMed
  130. PLoS One. 2013 Aug 21;8(8):e70023 - PubMed
  131. Circ Res. 2015 Apr 24;116(9):1561-78 - PubMed
  132. Stem Cell Reports. 2014 Jan 23;2(2):205-18 - PubMed
  133. Circ Res. 2013 Aug 30;113(6):810-34 - PubMed
  134. Arterioscler Thromb Vasc Biol. 2010 May;30(5):984-91 - PubMed
  135. Nature. 2011 Mar 10;471(7337):230-4 - PubMed
  136. Nature. 1958 Jul 5;182(4627):64-5 - PubMed
  137. J Am Coll Cardiol. 2014 Aug 5;64(5):436-48 - PubMed
  138. Cell. 2008 Sep 5;134(5):877-86 - PubMed
  139. Nat Biotechnol. 2012 Dec;30(12):1244-8 - PubMed
  140. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12705-10 - PubMed
  141. Circulation. 2008 Mar 25;117(12):1555-62 - PubMed

Publication Types

Grant support