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Jia HZ, Pang X, Fan ZJ, et al. Iontophoresis-assisted corneal crosslinking using 0.1% riboflavin for progressive keratoconus. Int J Ophthalmol. 2017;10(5):717-722doi: 10.18240/ijo.2017.05.09.
Jia, H. Z., Pang, X., Fan, Z. J., Li, N., Li, G., & Peng, X. J. (2017). Iontophoresis-assisted corneal crosslinking using 0.1% riboflavin for progressive keratoconus. International journal of ophthalmology, 10(5), 717-722. https://doi.org/10.18240/ijo.2017.05.09
Jia, Hong-Zhen, et al. "Iontophoresis-assisted corneal crosslinking using 0.1% riboflavin for progressive keratoconus." International journal of ophthalmology vol. 10,5 (2017): 717-722. doi: https://doi.org/10.18240/ijo.2017.05.09
Jia HZ, Pang X, Fan ZJ, Li N, Li G, Peng XJ. Iontophoresis-assisted corneal crosslinking using 0.1% riboflavin for progressive keratoconus. Int J Ophthalmol. 2017 May 18;10(5):717-722. doi: 10.18240/ijo.2017.05.09. eCollection 2017. PMID: 28546926; PMCID: PMC5437457.
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Int J Ophthalmol. 2017 May 18;10(5):717-722. doi: 10.18240/ijo.2017.05.09. eCollection 2017.

Iontophoresis-assisted corneal crosslinking using 0.1% riboflavin for progressive keratoconus.

International journal of ophthalmology

Hong-Zhen Jia, Xu Pang, Zheng-Jun Fan, Na Li, Gang Li, Xiu-Jun Peng

Affiliations

  1. Chinese PLA Medical School, Beijing 100853, China.
  2. Department of Ophthalmology, Chinese PLA Navy General Hospital, Beijing 100048, China.

PMID: 28546926 PMCID: PMC5437457 DOI: 10.18240/ijo.2017.05.09

Abstract

AIM: To report the clinical results of iontophoresis-assisted epithelium-on corneal crosslinking (I-CXL) using 0.1% riboflavin in distilled water for progressive keratoconus.

METHODS: In this prospective clinical study, we examined 94 eyes of 75 patients with progressive keratoconus who were treated with I-CXL using 0.1% riboflavin in distilled water. Best correct visual acuity (BCVA), Scheimpflug tomography, corneal topography, anterior segment optical coherence tomography, intraocular pressure, and endothelial cell density were evaluated at baseline and 1, 3, 6, 12, and 24mo after I-CXL.

RESULTS: After 24mo I-CXL, compared to the level at baseline, BCVA significantly improved 0.14±0.07 (

CONCLUSION: I-CXL using 0.1% riboflavin halts keratoconus progression within 24mo, resulting in a significant improvement in visual and topographic parameters. Moreover, the depth of the demarcation line is similar to that previously reported in standard epithelium-off CXL procedures.

Keywords: corneal cross-linking; distilled water; iontophoresis; keratoconus; riboflavin

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