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Akeda K, Ohishi K, Masuda K, et al. Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial. Asian Spine J. 2017;11(3):380-389doi: 10.4184/asj.2017.11.3.380.
Akeda, K., Ohishi, K., Masuda, K., Bae, W. C., Takegami, N., Yamada, J., Nakamura, T., Sakakibara, T., Kasai, Y., & Sudo, A. (2017). Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial. Asian spine journal, 11(3), 380-389. https://doi.org/10.4184/asj.2017.11.3.380
Akeda, Koji, et al. "Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial." Asian spine journal vol. 11,3 (2017): 380-389. doi: https://doi.org/10.4184/asj.2017.11.3.380
Akeda K, Ohishi K, Masuda K, Bae WC, Takegami N, Yamada J, Nakamura T, Sakakibara T, Kasai Y, Sudo A. Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial. Asian Spine J. 2017 Jun;11(3):380-389. doi: 10.4184/asj.2017.11.3.380. Epub 2017 Jun 15. PMID: 28670405; PMCID: PMC5481592.
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Asian Spine J. 2017 Jun;11(3):380-389. doi: 10.4184/asj.2017.11.3.380. Epub 2017 Jun 15.

Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial.

Asian spine journal

Koji Akeda, Kohshi Ohishi, Koichi Masuda, Won C Bae, Norihiko Takegami, Junichi Yamada, Tomoki Nakamura, Toshihiko Sakakibara, Yuichi Kasai, Akihiro Sudo

Affiliations

  1. Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
  2. Blood Transfusion Service, Mie University Hospital, Tsu, Japan.
  3. Department of Orthopaedic Surgery, University of California, San Diego, CA, USA.
  4. Department of Radiology, University of California, San Diego, CA, USA.
  5. Department of Spinal Surgery and Medical Engineering, Mie University Graduate School of Medicine, Tsu, Japan.

PMID: 28670405 PMCID: PMC5481592 DOI: 10.4184/asj.2017.11.3.380

Abstract

STUDY DESIGN: Preliminary clinical trial.

PURPOSE: To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain.

OVERVIEW OF LITERATURE: PRP, which is comprised of autologous growth factors and cytokines, has been widely used in the clinical setting for tissue regeneration and repair. PRP has been shown

METHODS: Inclusion criteria for this study included chronic low back pain without leg pain for more than 3 months; one or more lumbar discs (L3/L4 to L5/S1) with evidence of degeneration, as indicated via magnetic resonance imaging (MRI); and at least one symptomatic disc, confirmed using standardized provocative discography. PRP releasate, isolated from clotted PRP, was injected into the center of the nucleus pulposus. Outcome measures included the use of a visual analog scale (VAS) and the Roland-Morris Disability Questionnaire (RDQ), as well as X-ray and MRI (T2-quantification).

RESULTS: Data were analyzed from 14 patients (8 men and 6 women; mean age, 33.8 years). The average follow-up period was 10 months. Following treatment, no patient experienced adverse events or significant narrowing of disc height. The mean pain scores before treatment (VAS, 7.5±1.3; RDQ, 12.6±4.1) were significantly decreased at one month, and this was generally sustained throughout the observation period (6 months after treatment: VAS, 3.2±2.4, RDQ; 3.6±4.5 and 12 months: VAS, 2.9±2.8; RDQ, 2.8±3.9;

CONCLUSIONS: We demonstrated that intradiscal injection of autologous PRP releasate in patients with low back pain was safe, with no adverse events observed during follow-up. Future randomized controlled clinical studies should be performed to systematically evaluate the effects of this therapy.

Keywords: Clinical trial; Intervertebral disc degeneration; Low back pain; Platelet-rich plasma

Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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