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Lee MR, Lin C, Lu CC, et al. YC-1 induces G. Biomedicine (Taipei). 2017;7(2):12doi: 10.1051/bmdcn/2017070205.
Lee, M. R., Lin, C., Lu, C. C., Kuo, S. C., Tsao, J. W., Juan, Y. N., Chiu, H. Y., Lee, F. Y., Yang, J. S., & Tsai, F. J. (2017). YC-1 induces G. BioMedicine, 7(2), 12. https://doi.org/10.1051/bmdcn/2017070205
Lee, Miau-Rong, et al. "YC-1 induces G." BioMedicine vol. 7,2 (2017): 12. doi: https://doi.org/10.1051/bmdcn/2017070205
Lee MR, Lin C, Lu CC, Kuo SC, Tsao JW, Juan YN, Chiu HY, Lee FY, Yang JS, Tsai FJ. YC-1 induces G. Biomedicine (Taipei). 2017 Jun;7(2):12. doi: 10.1051/bmdcn/2017070205. Epub 2017 Jun 14. PMID: 28612710; PMCID: PMC5479426.
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Biomedicine (Taipei). 2017 Jun;7(2):12. doi: 10.1051/bmdcn/2017070205. Epub 2017 Jun 14.

YC-1 induces G.

BioMedicine

Miau-Rong Lee, Chingju Lin, Chi-Cheng Lu, Sheng-Chu Kuo, Je-Wei Tsao, Yu-Ning Juan, Hong-Yi Chiu, Fang-Yu Lee, Jai-Sing Yang, Fuu-Jen Tsai

Affiliations

  1. Department of Biochemistry, China Medical University, Taichung 404, Taiwan.
  2. Department of Physiology, China Medical University, Taichung 404, Taiwan.
  3. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan - Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan.
  4. Chinese Medicinal Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404, Taiwan - School of Pharmacy, China Medical University, Taichung 404, Taiwan.
  5. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
  6. Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan.
  7. Yung-Shin Pharmaceutical Industry Co., Ltd., Tachia, Taichung 437, Taiwan.
  8. Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan - School of Chinese Medicine, China Medical University, Taichung 404, Taiwan - Department of Medical Genetics, China Medical University Hospital, Taichung 404, Taiwan.

PMID: 28612710 PMCID: PMC5479426 DOI: 10.1051/bmdcn/2017070205

Abstract

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on cisplatin-resistant human oral cancer cell line, CAR. Our results indicated that YC-1 induced a concentration-dependent and time-dependent decrease in viability of CAR cells analyzed by MTT assay. Real-time image analysis of CAR cells by IncuCyte™ Kinetic Live Cell Imaging System demonstrated that YC-1 inhibited cell proliferation and reduced cell confluence in a time-dependent manner. Results from flow cytometric analysis revealed that YC-1 promoted G

© Author(s) 2017. This article is published with open access by China Medical University.

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