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Lewis JE, Atlas SE, Rasul A, et al. New method of sudomotor function measurement to detect microvascular disease and sweat gland nerve or unmyelinated C fiber dysfunction in adults with retinopathy. J Diabetes Metab Disord. 2017;16:26doi: 10.1186/s40200-017-0307-5.
Lewis, J. E., Atlas, S. E., Rasul, A., Farooqi, A., Lantigua, L., Higuera, O. L., Fiallo, A., Laria, L., Picciani, R., Wals, K., Yehoshua, Z., Mendez, A., Konefal, J., Goldberg, S., & Woolger, J. (2017). New method of sudomotor function measurement to detect microvascular disease and sweat gland nerve or unmyelinated C fiber dysfunction in adults with retinopathy. Journal of diabetes and metabolic disorders, 1626. https://doi.org/10.1186/s40200-017-0307-5
Lewis, John E, et al. "New method of sudomotor function measurement to detect microvascular disease and sweat gland nerve or unmyelinated C fiber dysfunction in adults with retinopathy." Journal of diabetes and metabolic disorders vol. 16 (2017): 26. doi: https://doi.org/10.1186/s40200-017-0307-5
Lewis JE, Atlas SE, Rasul A, Farooqi A, Lantigua L, Higuera OL, Fiallo A, Laria L, Picciani R, Wals K, Yehoshua Z, Mendez A, Konefal J, Goldberg S, Woolger J. New method of sudomotor function measurement to detect microvascular disease and sweat gland nerve or unmyelinated C fiber dysfunction in adults with retinopathy. J Diabetes Metab Disord. 2017 Jun 12;16:26. doi: 10.1186/s40200-017-0307-5. eCollection 2017. PMID: 28616394; PMCID: PMC5468959.
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J Diabetes Metab Disord. 2017 Jun 12;16:26. doi: 10.1186/s40200-017-0307-5. eCollection 2017.

New method of sudomotor function measurement to detect microvascular disease and sweat gland nerve or unmyelinated C fiber dysfunction in adults with retinopathy.

Journal of diabetes and metabolic disorders

John E Lewis, Steven E Atlas, Ammar Rasul, Ashar Farooqi, Laura Lantigua, Oscar L Higuera, Andrea Fiallo, Lianette Laria, Renata Picciani, Ken Wals, Zohar Yehoshua, Armando Mendez, Janet Konefal, Sharon Goldberg, Judi Woolger

Affiliations

  1. Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th Street Suite #1482A, Miami, FL 33136 USA.
  2. Department of Medicine, University of Miami Miller School of Medicine, Miami, FL USA.
  3. Laria Eye Care, Miami, FL USA.
  4. Aran Eye Associates, Miami, FL USA.
  5. Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL USA.
  6. Department of Family Medicine and Community Health, University of Miami, Miami Miller School of Medicine, Miami, FL USA.
  7. Glow Health PA, Bay Harbor Islands, FL USA.

PMID: 28616394 PMCID: PMC5468959 DOI: 10.1186/s40200-017-0307-5

Abstract

BACKGROUND: Diabetes-associated microvascular complications such as retinopathy and neuropathy often lead to end-organ and tissue damage. Impaired skin microcirculation often precedes the detection of other advanced diabetic complications. The ANS-1 system contains a redesigned sympathetic skin response (ANS-1 SSR) device that measures sudomotor function, a photoplethysmography sensor, and a blood pressure device to comprehensively assess cardiac autonomic neuropathy and endothelial dysfunction. The purpose of this study was to determine the relationships between the ANS-1 SSR amplitude measured at the: (a) negative electrode (Nitric Oxide [NO] Sweat Peak) with microvascular diseases and associated vascular blood markers and (b) positive electrode (iSweat Peak) with C fiber function.

METHODS: All participants (healthy controls

RESULTS: The ANS-1 System Cardiometabolic Risk Score and all indicators of quality of life on the SF-36, other than Emotional Role Functioning, were significantly worse in the retinopathy patients. The sudomotor response marker NO Sweat Peak had a sensitivity of 88% and a specificity of 68% (Area Under the Curve = 0.81,

CONCLUSION: The results of the study show that this new method of measuring sympathetic skin response should be useful for detecting the earliest manifestations of microvascular disease and symptoms of C fiber dysfunction.

Keywords: ANS-1; C fiber dysfunction; Diabetes complications; Microvascular diseases; NO Sweat Peak; Retinopathy; Sudomotor test; iSweat Peak

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