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Demnitz N, Zsoldos E, Mahmood A, et al. Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Front Aging Neurosci. 2017;9:155doi: 10.3389/fnagi.2017.00155.
Demnitz, N., Zsoldos, E., Mahmood, A., Mackay, C. E., Kivimäki, M., Singh-Manoux, A., Dawes, H., Johansen-Berg, H., Ebmeier, K. P., & Sexton, C. E. (2017). Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Frontiers in aging neuroscience, 9155. https://doi.org/10.3389/fnagi.2017.00155
Demnitz, Naiara, et al. "Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults." Frontiers in aging neuroscience vol. 9 (2017): 155. doi: https://doi.org/10.3389/fnagi.2017.00155
Demnitz N, Zsoldos E, Mahmood A, Mackay CE, Kivimäki M, Singh-Manoux A, Dawes H, Johansen-Berg H, Ebmeier KP, Sexton CE. Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Front Aging Neurosci. 2017 May 23;9:155. doi: 10.3389/fnagi.2017.00155. eCollection 2017. PMID: 28588477; PMCID: PMC5440513.
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Front Aging Neurosci. 2017 May 23;9:155. doi: 10.3389/fnagi.2017.00155. eCollection 2017.

Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults.

Frontiers in aging neuroscience

Naiara Demnitz, Enikő Zsoldos, Abda Mahmood, Clare E Mackay, Mika Kivimäki, Archana Singh-Manoux, Helen Dawes, Heidi Johansen-Berg, Klaus P Ebmeier, Claire E Sexton

Affiliations

  1. Department of Psychiatry, University of Oxford, Warneford HospitalOxford, United Kingdom.
  2. Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of OxfordJohn Radcliffe Hospital, Oxford, United Kingdom.
  3. Department of Epidemiology and Public Health, University College LondonLondon, United Kingdom.
  4. Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes UniversityOxford, United Kingdom.

PMID: 28588477 PMCID: PMC5440513 DOI: 10.3389/fnagi.2017.00155

Abstract

Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.

Keywords: MRI; aging; balance; cognition; gait; gray matter; mobility

References

  1. Chronobiol Int. 2015 Feb;32(1):136-42 - PubMed
  2. J Neural Transm (Vienna). 2015 Aug;122 Suppl 1:S55-61 - PubMed
  3. Neuroimage. 2016 Jun;133:41-52 - PubMed
  4. Neuroimage. 2009 Jan 1;44(1):83-98 - PubMed
  5. Front Aging Neurosci. 2014 Jun 10;6:104 - PubMed
  6. PLoS Med. 2017 Mar 21;14 (3):e1002259 - PubMed
  7. Stroke. 2010 Aug;41(8):1652-8 - PubMed
  8. Ann Neurol. 2015 Feb;77(2):251-61 - PubMed
  9. Neuroimage. 2004;23 Suppl 1:S208-19 - PubMed
  10. J Youth Adolesc. 1991 Apr;20(2):149-66 - PubMed
  11. Gerontology. 2011;57(3):203-10 - PubMed
  12. Neuroimage. 2016 Jan 15;125:1063-78 - PubMed
  13. Front Aging Neurosci. 2017 Feb 13;9:17 - PubMed
  14. Am J Geriatr Psychiatry. 2017 Mar;25(3):209-217 - PubMed
  15. Public Health Nurs. 2001 Jan-Feb;18(1):54-63 - PubMed
  16. J Gerontol A Biol Sci Med Sci. 2008 Dec;63(12):1344-9 - PubMed
  17. J Gerontol A Biol Sci Med Sci. 2008 Dec;63(12):1380-8 - PubMed
  18. Arch Gerontol Geriatr. 2014 Mar-Apr;58(2):278-82 - PubMed
  19. Neurosci Biobehav Rev. 2016 May;64:326-45 - PubMed
  20. Neurobiol Aging. 2012 Sep;33(9):1900-12 - PubMed
  21. Neuroimage. 2001 Jul;14(1 Pt 1):21-36 - PubMed
  22. Stroke. 2009 Dec;40(12):3816-20 - PubMed
  23. Diabetes Care. 2012 Sep;35(9):1907-12 - PubMed
  24. J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1226-37 - PubMed
  25. J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):996-1003 - PubMed
  26. Psychol Bull. 2008 Jan;134(1):109-37 - PubMed
  27. Brain Res Brain Res Rev. 2000 Mar;31(2-3):236-50 - PubMed
  28. J Am Geriatr Soc. 2013 Jul;61(7):1074-9 - PubMed
  29. Exp Gerontol. 2015 Jan;61:98-104 - PubMed
  30. J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):M221-31 - PubMed
  31. Neuroimage. 2006 Jul 15;31(4):1487-505 - PubMed
  32. J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1375-88 - PubMed
  33. Age Ageing. 2006 Sep;35 Suppl 2:ii7-ii11 - PubMed
  34. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157-65 - PubMed
  35. J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1184-94 - PubMed
  36. Neuroradiology. 2015 Aug;57(8):851-61 - PubMed
  37. Neuroimage. 2012 Apr 2;60(2):871-8 - PubMed
  38. Brain. 2007 Sep;130(Pt 9):2375-86 - PubMed
  39. J Am Geriatr Soc. 2009 Feb;57(2):251-9 - PubMed
  40. Exp Gerontol. 2016 Apr;76:72-9 - PubMed
  41. J Clin Mov Disord. 2015 Jan 20;2:1 - PubMed
  42. J Alzheimers Dis. 2017;57(3):845-856 - PubMed
  43. Neuroimage. 2014 May 15;92:381-97 - PubMed
  44. Int J Epidemiol. 2005 Apr;34(2):251-6 - PubMed
  45. Hum Brain Mapp. 2002 Nov;17(3):143-55 - PubMed
  46. Hum Brain Mapp. 2016 Apr;37(4):1486-511 - PubMed
  47. Psychiatry Res. 1989 May;28(2):193-213 - PubMed
  48. J R Soc Med. 1992 Jul;85(7):399-402 - PubMed
  49. Alzheimers Dement. 2014 May;10(3):328-35 - PubMed
  50. Neuroepidemiology. 2005;24(1-2):8-14 - PubMed
  51. J Am Geriatr Soc. 2003 Jun;51(6):841-6 - PubMed
  52. J Gerontol A Biol Sci Med Sci. 2007 Sep;62(9):1048-55 - PubMed
  53. J Consult Psychol. 1955 Oct;19(5):393-4 - PubMed
  54. BMC Psychiatry. 2014 May 30;14:159 - PubMed
  55. Neural Plast. 2005;12(2-3):161-74; discussion 263-72 - PubMed
  56. Gait Posture. 2016 Oct;50:164-174 - PubMed

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