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Eckert F, Jelas I, Oehme M, et al. Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects . Oncoimmunology. 2017;6(6):e1323161doi: 10.1080/2162402X.2017.1323161.
Eckert, F., Jelas, I., Oehme, M., Huber, S. M., Sonntag, K., Welker, C., Gillies, S. D., Strittmatter, W., Zips, D., Handgretinger, R., & Schilbach, K. (2017). Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects . Oncoimmunology, 6(6), e1323161. https://doi.org/10.1080/2162402X.2017.1323161
Eckert, Franziska, et al. "Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects ." Oncoimmunology vol. 6,6 (2017): e1323161. doi: https://doi.org/10.1080/2162402X.2017.1323161
Eckert F, Jelas I, Oehme M, Huber SM, Sonntag K, Welker C, Gillies SD, Strittmatter W, Zips D, Handgretinger R, Schilbach K. Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects . Oncoimmunology. 2017 Apr 28;6(6):e1323161. doi: 10.1080/2162402X.2017.1323161. eCollection 2017. PMID: 28680762; PMCID: PMC5486191.
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Oncoimmunology. 2017 Apr 28;6(6):e1323161. doi: 10.1080/2162402X.2017.1323161. eCollection 2017.

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects .

Oncoimmunology

Franziska Eckert, Ivan Jelas, Moritz Oehme, Stephan M Huber, Katja Sonntag, Christian Welker, Stephen D Gillies, Wolfgang Strittmatter, Daniel Zips, Rupert Handgretinger, Karin Schilbach

Affiliations

  1. Department of Radiation Oncology, Eberhard Karls University Tübingen, Tübingen, Germany.
  2. Department of General Pediatrics, Oncology/Hematology, Eberhard Karls University Tübingen, Tübingen, Germany.
  3. Provenance Biopharmaceuticals, Carlisle, MA, USA.
  4. Merck Serono R&D, Global Early Development, Darmstadt, Germany.

PMID: 28680762 PMCID: PMC5486191 DOI: 10.1080/2162402X.2017.1323161

Abstract

NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and differentiation of the tumor cells. Here, we locally irradiated the tumors, increasing necrosis and consequently intratumoral immune cytokine availability, and asked whether this effect may surmount efficacy of single treatment modality. Humanized mice bearing bilateral rhabdomyosarcoma xenografts were evaluated for tumor burden and survival after irradiation, systemic NHS-IL12 therapy or a combination of both. Intratumoral immune compartments were characterized by immunohistochemistry and molecular methods. T

Keywords: Differentiation; IL12; glioma; immunocytokine; radiotherapy; rhabdomyosarcoma; senescence

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