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Sgherza N, Abruzzese E, Perla G, et al. Onset of chronic myeloid leukemia with complex karyotype in a pregnant patient: case report and revision of literature. Ther Clin Risk Manag. 2017;13:751-755doi: 10.2147/TCRM.S137103.
Sgherza, N., Abruzzese, E., Perla, G., Minervini, M. M., Chiello, V., Sciannamè, N., & Cascavilla, N. (2017). Onset of chronic myeloid leukemia with complex karyotype in a pregnant patient: case report and revision of literature. Therapeutics and clinical risk management, 13751-755. https://doi.org/10.2147/TCRM.S137103
Sgherza, Nicola, et al. "Onset of chronic myeloid leukemia with complex karyotype in a pregnant patient: case report and revision of literature." Therapeutics and clinical risk management vol. 13 (2017): 751-755. doi: https://doi.org/10.2147/TCRM.S137103
Sgherza N, Abruzzese E, Perla G, Minervini MM, Chiello V, Sciannamè N, Cascavilla N. Onset of chronic myeloid leukemia with complex karyotype in a pregnant patient: case report and revision of literature. Ther Clin Risk Manag. 2017 Jun 27;13:751-755. doi: 10.2147/TCRM.S137103. eCollection 2017. PMID: 28721056; PMCID: PMC5499781.
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Ther Clin Risk Manag. 2017 Jun 27;13:751-755. doi: 10.2147/TCRM.S137103. eCollection 2017.

Onset of chronic myeloid leukemia with complex karyotype in a pregnant patient: case report and revision of literature.

Therapeutics and clinical risk management

Nicola Sgherza, Elisabetta Abruzzese, Gianni Perla, Maria Marta Minervini, Vincenzo Chiello, Natale Sciannamè, Nicola Cascavilla

Affiliations

  1. Hematology, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG).
  2. Hematology, Sant'Eugenio Hospital, Roma.
  3. Gynecology and Obstetrics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.

PMID: 28721056 PMCID: PMC5499781 DOI: 10.2147/TCRM.S137103

Abstract

Approximately 10%-12% of patients in chronic-phase chronic myeloid leukemia (CP-CML) have additional chromosomal aberrations at diagnosis; moreover, CML occurs in up to 10% of pregnancy-associated leukemias, with an annual incidence of 1 per 100,000 pregnancies. In this report we describe the case of a 36-year-old female with CP-CML diagnosed in the 18th week of pregnancy and with a new complex variant translocation t(4;9;22;21)(q24;q34;q11;q22) and an additional chromosomal aberration t(1;20)(p36;p11). In consideration of her pregnancy, the patient strictly monitored her blood cell count without any specific treatment. At 32 weeks of pregnancy, the patient delivered via cesarean section a healthy baby girl. After 10 days from childbirth, dasatinib was started at a standard dosage of 100 mg/day and 3 months later complete cytogenetic response and major molecular response were obtained, with the achievement of an optimal response according to European Leukemia Net recommendations and showing efficacy of this tyrosine kinase inhibitor (TKI) in the presence of a complex karyotype.

Keywords: additional chromosomal aberration; chronic myeloid leukemia; complex karyotype; pregnancy; tyrosine kinase inhibitor; variant translocation

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

References

  1. BMJ Case Rep. 2010 Oct 21;2010:null - PubMed
  2. Blood. 2012 Jul 26;120(4):761-7 - PubMed
  3. Blood. 2011 Jun 23;117(25):6793-800 - PubMed
  4. Cancer Genet. 2012 Nov;205(11):563-71 - PubMed
  5. Hum Genet. 1987 May;76(1):109 - PubMed
  6. Blood. 2009 Feb 19;113(8):1619-30 - PubMed
  7. Expert Rev Hematol. 2016 Aug;9(8):781-91 - PubMed
  8. Curr Opin Oncol. 2008 Jan;20(1):112-21 - PubMed
  9. Oncol Rep. 2008 Jul;20(1):99-104 - PubMed
  10. Cancer. 2010 Jun 1;116(11):2673-81 - PubMed
  11. Am J Hematol. 2015 Dec;90(12 ):1111-5 - PubMed
  12. Blood. 2011 Dec 22;118(26):6760-8 - PubMed
  13. Best Pract Res Clin Haematol. 2009 Sep;22(3):455-74 - PubMed
  14. Blood. 2013 Aug 8;122(6):872-84 - PubMed
  15. Cytogenet Genome Res. 2009;127(1):1-4 - PubMed
  16. Leuk Lymphoma. 2010 Sep;51(9):1751-3 - PubMed
  17. Nature. 1973 Jun 1;243(5405):290-3 - PubMed
  18. Blood. 2014 Feb 13;123(7):974-84 - PubMed
  19. Blood. 2001 Sep 15;98(6):1732-8 - PubMed
  20. Cancer. 2007 Oct 1;110(7):1509-19 - PubMed
  21. J Clin Oncol. 2010 Jun 1;28(16):2748-54 - PubMed
  22. Adv Hematol. 2010;2010:136252 - PubMed

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