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NPJ Breast Cancer. 2016 Apr 20;2:16009. doi: 10.1038/npjbcancer.2016.9. eCollection 2016.

TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients.

NPJ breast cancer

Elizabeth Comen, Paulina Wojnarowicz, Venkatraman E Seshan, Riddhi Shah, Courtney Coker, Larry Norton, Robert Benezra

Affiliations

  1. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  2. Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  3. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

PMID: 28721376 PMCID: PMC5515342 DOI: 10.1038/npjbcancer.2016.9

Abstract

We have previously shown a novel antimetastatic role for neutrophils in the premetastatic lung of mice in models of breast cancer. Here we expand on those findings in the context of human breast cancer. We assessed the cytotoxicity of neutrophils from 90 newly diagnosed breast cancer patients, 24 ductal carcinoma

Conflict of interest statement

The authors declare no conflict of interest.

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