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Patin EC, Orr SJ, Schaible UE. Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity. Front Immunol. 2017;8:861doi: 10.3389/fimmu.2017.00861.
Patin, E. C., Orr, S. J., & Schaible, U. E. (2017). Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity. Frontiers in immunology, 8861. https://doi.org/10.3389/fimmu.2017.00861
Patin, Emmanuel C, et al. "Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity." Frontiers in immunology vol. 8 (2017): 861. doi: https://doi.org/10.3389/fimmu.2017.00861
Patin EC, Orr SJ, Schaible UE. Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity. Front Immunol. 2017 Jul 25;8:861. doi: 10.3389/fimmu.2017.00861. eCollection 2017. PMID: 28791019; PMCID: PMC5525440.
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Front Immunol. 2017 Jul 25;8:861. doi: 10.3389/fimmu.2017.00861. eCollection 2017.

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity.

Frontiers in immunology

Emmanuel C Patin, Selinda Jane Orr, Ulrich E Schaible

Affiliations

  1. Priority Area Infections, Department Cellular Microbiology, Forschungszentrum Borstel, and German Center for Infection Research, TTU-TB, Borstel, Germany.
  2. Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.

PMID: 28791019 PMCID: PMC5525440 DOI: 10.3389/fimmu.2017.00861

Abstract

The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6'-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle's immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle's biology with an emphasis on its diverse functions in immunity.

Keywords: anti-inflammatory; innate immunity; macrophage inducible C-type lectin; phagocytosis; trehalose dimycolate

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