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Li L, Tan TD, Zhang YQ, et al. Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles. Org Biomol Chem. 2017;15(40):8483-8492doi: 10.1039/c7ob01895a.
Li, L., Tan, T. D., Zhang, Y. Q., Liu, X., & Ye, L. W. (2017). Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles. Organic & biomolecular chemistry, 15(40), 8483-8492. https://doi.org/10.1039/c7ob01895a
Li, Long, et al. "Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles." Organic & biomolecular chemistry vol. 15,40 (2017): 8483-8492. doi: https://doi.org/10.1039/c7ob01895a
Li L, Tan TD, Zhang YQ, Liu X, Ye LW. Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles. Org Biomol Chem. 2017 Oct 18;15(40):8483-8492. doi: 10.1039/c7ob01895a. PMID: 28875211.
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Org Biomol Chem. 2017 Oct 18;15(40):8483-8492. doi: 10.1039/c7ob01895a.

Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles.

Organic & biomolecular chemistry

Long Li, Tong-De Tan, Ying-Qi Zhang, Xin Liu, Long-Wu Ye

Affiliations

  1. State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. [email protected].

PMID: 28875211 DOI: 10.1039/c7ob01895a

Abstract

Isoxazoles, as masked 1,3-dicarbonyl equivalents, have proven to be versatile building blocks and pivotal intermediates for the construction of a variety of useful azacycles with molecular complexity. As a result, a range of new reactions have been discovered based on isoxazoles in the past decade. However, the relevant reactions of isoxazoles with alkynes have seldom been explored. In this review, we will focus on the recent progress in the transition-metal-catalyzed formal annulations for the efficient synthesis of N-heterocycles between alkynes and isoxazoles by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible.

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