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Pötter-Nerger M, Reese R, Steigerwald F, et al. Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task. Front Hum Neurosci. 2017;11:436doi: 10.3389/fnhum.2017.00436.
Pötter-Nerger, M., Reese, R., Steigerwald, F., Heiden, J. A., Herzog, J., Moll, C. K. E., Hamel, W., Ramirez-Pasos, U., Falk, D., Mehdorn, M., Gerloff, C., Deuschl, G., & Volkmann, J. (2017). Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task. Frontiers in human neuroscience, 11436. https://doi.org/10.3389/fnhum.2017.00436
Pötter-Nerger, Monika, et al. "Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task." Frontiers in human neuroscience vol. 11 (2017): 436. doi: https://doi.org/10.3389/fnhum.2017.00436
Pötter-Nerger M, Reese R, Steigerwald F, Heiden JA, Herzog J, Moll CKE, Hamel W, Ramirez-Pasos U, Falk D, Mehdorn M, Gerloff C, Deuschl G, Volkmann J. Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task. Front Hum Neurosci. 2017 Sep 07;11:436. doi: 10.3389/fnhum.2017.00436. eCollection 2017. PMID: 28936169; PMCID: PMC5594073.
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Front Hum Neurosci. 2017 Sep 07;11:436. doi: 10.3389/fnhum.2017.00436. eCollection 2017.

Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task.

Frontiers in human neuroscience

Monika Pötter-Nerger, Rene Reese, Frank Steigerwald, Jan Arne Heiden, Jan Herzog, Christian K E Moll, Wolfgang Hamel, Uri Ramirez-Pasos, Daniela Falk, Maximilian Mehdorn, Christian Gerloff, Günther Deuschl, Jens Volkmann

Affiliations

  1. Department of Neurology, Christian-Albrechts-UniversityKiel, Germany.
  2. Department of Neurology, University Hamburg-EppendorfHamburg, Germany.
  3. Department of Neurology, University RostockRostock, Germany.
  4. Department of Neurology, Julius-Maximilian UniversityWürzburg, Germany.
  5. Department of Neurophysiology, University Hamburg-EppendorfHamburg, Germany.
  6. Department of Neurosurgery, University Hamburg-EppendorfHamburg, Germany.
  7. Department of Neurosurgery, Christian-Albrechts-UniversityKiel, Germany.

PMID: 28936169 PMCID: PMC5594073 DOI: 10.3389/fnhum.2017.00436

Abstract

The aim of the study was to record movement-related single unit activity (SUA) in the human subthalamic nucleus (STN) during a standardized motor task of the upper limb. We performed microrecordings from the motor region of the human STN and registered kinematic data in 12 patients with Parkinson's disease (PD) undergoing deep brain stimulation surgery (seven women, mean age 62.0 ± 4.7 years) while they intraoperatively performed visually cued reach-to-grasp movements using a grip device. SUA was analyzed offline in relation to different aspects of the movement (attention, start of the movement, movement velocity, button press) in terms of firing frequency, firing pattern, and oscillation. During the reach-to-grasp movement, 75/114 isolated subthalamic neurons exhibited movement-related activity changes. The largest proportion of single units showed modulation of firing frequency during several phases of the reach and grasp (polymodal neurons, 45/114), particularly an increase of firing rate during the reaching phase of the movement, which often correlated with movement velocity. The firing pattern (bursting, irregular, or tonic) remained unchanged during movement compared to rest. Oscillatory single unit firing activity (predominantly in the theta and beta frequency) decreased with movement onset, irrespective of oscillation frequency. This study shows for the first time specific, task-related, SUA changes during the reach-to-grasp movement in humans.

Keywords: Parkinson’s disease; beta oscillation; deep brain stimulation; neurophysiology; reach-to-grasp movement; subthalamic nucleus

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