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Leng S, Yang M, Zhao Y, et al. PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition. Oncotarget. 2017;8(35):58184-58198doi: 10.18632/oncotarget.16436.
Leng, S., Yang, M., Zhao, Y., Zhao, J., Zeng, Z., Yang, Y., Yuan, J., Lv, B., Jun, F., & Wang, B. (2017). PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition. Oncotarget, 8(35), 58184-58198. https://doi.org/10.18632/oncotarget.16436
Leng, Shusheng, et al. "PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition." Oncotarget vol. 8,35 (2017): 58184-58198. doi: https://doi.org/10.18632/oncotarget.16436
Leng S, Yang M, Zhao Y, Zhao J, Zeng Z, Yang Y, Yuan J, Lv B, Jun F, Wang B. PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition. Oncotarget. 2017 Mar 22;8(35):58184-58198. doi: 10.18632/oncotarget.16436. eCollection 2017 Aug 29. PMID: 28938547; PMCID: PMC5601643.
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Oncotarget. 2017 Mar 22;8(35):58184-58198. doi: 10.18632/oncotarget.16436. eCollection 2017 Aug 29.

PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition.

Oncotarget

Shusheng Leng, Mingyang Yang, Yanhua Zhao, Jingfeng Zhao, Zhijun Zeng, Yunpeng Yang, Jiatian Yuan, Bo Lv, Fan Jun, Bing Wang

Affiliations

  1. General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu 610081, China.
  2. Intensive Care Unit, The First People's Hospital of Chengdu (Chengdu Combine Traditional Chinese and Western Medicine Hospital), Chengdu 610041, China.
  3. Department of Laboratory Medicine/Clinical Research Center of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
  4. General Surgery Department, Chongqing Dazu District People's Hospital, Chongqing 402360, China.
  5. Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
  6. Department of Pathology, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu 610081, China.

PMID: 28938547 PMCID: PMC5601643 DOI: 10.18632/oncotarget.16436

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal tumors worldwide, which is mainly due to the high recurrence and metastasis rate after hepatectomy. In this study, we found that PTIP expression was dramatically upregulated in human HCC tissues and cell lines. High expression of PTIP was shown to be associated with aggressive clinicopathological features, including liver cirrhosis, vascular invasion and advanced stage. In addition, PTIP overexpression was independently associated with shorter survival and increased HCC recurrence in patients. Knockdown of the PTIP expression significantly inhibited invasion and metastasis

Keywords: PAX interacting protein1 (PTIP); epithelial-mesenchymal transition (EMT); hepatocelluar carcinoma; metastasis; miRNA

Conflict of interest statement

CONFLICTS OF INTEREST None of the authors have any conflicts of interest to declare.

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