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Lian Y, Yan C, Ding J, et al. A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. Oncotarget. 2017;8(35):59435-59445doi: 10.18632/oncotarget.19738.
Lian, Y., Yan, C., Ding, J., Xia, R., Ma, Z., Hui, B., Ji, H., Zhou, J., & Wang, K. (2017). A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. Oncotarget, 8(35), 59435-59445. https://doi.org/10.18632/oncotarget.19738
Lian, Yifan, et al. "A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer." Oncotarget vol. 8,35 (2017): 59435-59445. doi: https://doi.org/10.18632/oncotarget.19738
Lian Y, Yan C, Ding J, Xia R, Ma Z, Hui B, Ji H, Zhou J, Wang K. A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. Oncotarget. 2017 Jul 31;8(35):59435-59445. doi: 10.18632/oncotarget.19738. eCollection 2017 Aug 29. PMID: 28938648; PMCID: PMC5601744.
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Oncotarget. 2017 Jul 31;8(35):59435-59445. doi: 10.18632/oncotarget.19738. eCollection 2017 Aug 29.

A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer.

Oncotarget

Yifan Lian, Changsheng Yan, Jie Ding, Rui Xia, Zhonghua Ma, Bingqing Hui, Hao Ji, Jing Zhou, Keming Wang

Affiliations

  1. The Second Clinical Medical College of Nanjing Medical University, Nanjing 210000, Jiangsu, People's Republic of China.
  2. Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian, People's Republic of China.
  3. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
  4. Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu, People's Republic of China.
  5. Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 210000 Jiangsu, People's Republic of China.

PMID: 28938648 PMCID: PMC5601744 DOI: 10.18632/oncotarget.19738

Abstract

Long noncoding RNAs (lncRNA) have been implicated in variety human cancer but their mechanisms of function are mainly undocumented. In the present study, we investigated lncRNAs alteration that contributed to colorectal cancer (CRC) by utilizing TCGA RNA sequencing data and other publicly available lncRNAs expression profiling data. Here, We screened out the CRC-associated lncRNA LL22NC03-N64E9.1, a key regulator of CRC development and progression. We also revealed that knockdown of LL22NC03-N64E9.1 inhibited cell proliferation, colony formation, tumorigenicity and apoptosis promotion, both

Keywords: KLF2; LL22NC03-N64E9.1; colorectal cancer; lncRNA; proliferation

Conflict of interest statement

CONFLICTS OF INTEREST No potential conflicts of interest were disclosed.

References

  1. Tumour Biol. 2016 Nov;37(11):14929-14937 - PubMed
  2. Oncogene. 2012 Apr 12;31(15):1988-94 - PubMed
  3. Gastroenterol Clin North Am. 2016 Sep;45(3):459-76 - PubMed
  4. Oncogene. 2004 Oct 21;23(49):8088-96 - PubMed
  5. Gut. 2016 Sep;65(9):1494-504 - PubMed
  6. RNA. 2013 Apr;19(4):429-42 - PubMed
  7. Prog Mol Biol Transl Sci. 2014;124:155-88 - PubMed
  8. CA Cancer J Clin. 2014 Mar-Apr;64(2):104-17 - PubMed
  9. Nat Struct Mol Biol. 2013 Nov;20(11):1250-7 - PubMed
  10. Cancer Cell. 2016 Apr 11;29(4):452-463 - PubMed
  11. Genome Res. 2013 Sep;23 (9):1446-61 - PubMed
  12. Cancer Res. 2011 Oct 15;71(20):6320-6 - PubMed
  13. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72 - PubMed
  14. Oncotarget. 2016 Feb 2;7(5):5226-39 - PubMed
  15. Oncotarget. 2015 Nov 3;6(34):35830-42 - PubMed
  16. Tumour Biol. 2016 Jun;37(6):7431-40 - PubMed
  17. Genome Res. 2012 Sep;22(9):1760-74 - PubMed
  18. J Hum Genet. 2017 Jan;62(1):41-47 - PubMed
  19. Mol Biosyst. 2016 Oct 18;12 (11):3247-3253 - PubMed
  20. J Clin Invest. 2016 Aug 1;126(8):2775-82 - PubMed
  21. Sci Rep. 2016 May 20;6:26524 - PubMed
  22. Bioorg Med Chem Lett. 2011 Jan 1;21(1):110-6 - PubMed
  23. Cancer Res. 2016 Nov 1;76(21):6299-6310 - PubMed
  24. JAMA. 2003 Mar 12;289(10 ):1288-96 - PubMed
  25. Biochemistry. 2016 Mar 22;55(11):1615-30 - PubMed
  26. J Natl Compr Canc Netw. 2016 Aug;14(8):1033-40 - PubMed
  27. J Exp Clin Cancer Res. 2015 Sep 11;34:100 - PubMed
  28. Pathology. 2014 Aug;46(5):396-401 - PubMed
  29. Oncogene. 2005 Jun 2;24(24):3875-85 - PubMed
  30. CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30 - PubMed
  31. Tumour Biol. 2015 Apr;36(4):3075-84 - PubMed

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