Display options
Cite
Jeong J, Kim S, Lim DS, et al. TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice. Exp Neurobiol. 2017;26(4):213-226doi: 10.5607/en.2017.26.4.213.
Jeong, J., Kim, S., Lim, D. S., Kim, S. H., Doh, H., Kim, S. D., & Song, Y. S. (2017). TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice. Experimental neurobiology, 26(4), 213-226. https://doi.org/10.5607/en.2017.26.4.213
Jeong, Jaewon, et al. "TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice." Experimental neurobiology vol. 26,4 (2017): 213-226. doi: https://doi.org/10.5607/en.2017.26.4.213
Jeong J, Kim S, Lim DS, Kim SH, Doh H, Kim SD, Song YS. TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice. Exp Neurobiol. 2017 Aug;26(4):213-226. doi: 10.5607/en.2017.26.4.213. Epub 2017 Aug 28. PMID: 28912644; PMCID: PMC5597552.
Copy Download .nbib Format: NLM
Share it on

Exp Neurobiol. 2017 Aug;26(4):213-226. doi: 10.5607/en.2017.26.4.213. Epub 2017 Aug 28.

TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice.

Experimental neurobiology

Jaewon Jeong, Soojin Kim, Da-Sol Lim, Seo-Hea Kim, Heeju Doh, So-Dam Kim, Yun Seon Song

Affiliations

  1. College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.

PMID: 28912644 PMCID: PMC5597552 DOI: 10.5607/en.2017.26.4.213

Abstract

Postconditioning has been shown to protect the mouse brain from ischemic injury. However, the neuroprotective mechanisms of postconditioning remain elusive. We have found that toll-like receptor 5 (TLR5) plays an integral role in postconditioning-induced neuroprotection through Akt/nuclear factor kappa B (NF-κB) activation in cerebral ischemia. Compared to animals that received 30 min of transient middle cerebral artery occlusion (tMCAO) group, animals that also underwent postconditioning showed a significant reduction of up to 60.51% in infarct volume. Postconditioning increased phospho-Akt (p-Akt) levels and NF-κB translocation to the nucleus as early as 1 h after tMCAO and oxygen-glucose deprivation. Furthermore, inhibition of Akt by Akt inhibitor IV decreased NF-κB promoter activity after postconditioning. Immunoprecipitation showed that interactions between TLR5, MyD88, and p-Akt were increased from postconditioning both

Keywords: Cerebral ischemia; Neuroprotection; Nuclear factor kappa B; Postconditioning; Toll-like receptor 5

References

  1. J Cereb Blood Flow Metab. 2008 Dec;28(12):1917-26 - PubMed
  2. Curr Biol. 1999 Jun 3;9(11):601-4 - PubMed
  3. Neurosci Lett. 2000 Jul 7;288(1):45-8 - PubMed
  4. J Neurochem. 2008 May;105(3):943-55 - PubMed
  5. J Neurosci. 2001 Jul 1;21(13):4668-77 - PubMed
  6. J Cereb Blood Flow Metab. 2008 Feb;28(2):232-41 - PubMed
  7. Cell Biol Int. 2008 Jan;32(1):128-35 - PubMed
  8. J Biol Chem. 2000 Nov 3;275(44):34035-40 - PubMed
  9. Can J Physiol Pharmacol. 2009 Jan;87(1):63-8 - PubMed
  10. J Cereb Blood Flow Metab. 2002 Nov;22(11):1283-96 - PubMed
  11. Nature. 2006 May 25;441(7092):431-6 - PubMed
  12. Eur J Anaesthesiol. 2010 Aug;27(8):747-56 - PubMed
  13. Lab Invest. 2010 Jul;90(7):1049-59 - PubMed
  14. Nat Med. 1999 May;5(5):554-9 - PubMed
  15. Am Heart J. 1996 Jul;132(1 Pt 1):78-83 - PubMed
  16. J Immunol. 2011 Oct 1;187(7):3831-9 - PubMed
  17. Trends Immunol. 2004 Dec;25(12):687-93 - PubMed
  18. J Immunol. 2008 Jun 15;180(12):8280-5 - PubMed
  19. J Biol Chem. 2006 Jul 7;281(27):18560-8 - PubMed
  20. Prog Neurobiol. 2017 Jan 18;: - PubMed
  21. Circ Res. 2004 Aug 6;95(3):230-2 - PubMed
  22. Trends Neurosci. 2003 May;26(5):248-54 - PubMed
  23. Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H579-88 - PubMed
  24. J Biol Chem. 2004 Jun 11;279(24):25179-88 - PubMed
  25. Nat Clin Pract Cardiovasc Med. 2005 Nov;2(11):568-75 - PubMed
  26. Nature. 2001 Apr 26;410(6832):1099-103 - PubMed
  27. J Immunol. 2001 Jan 15;166(2):1248-60 - PubMed
  28. Science. 1997 Oct 24;278(5338):687-9 - PubMed
  29. J Physiol Sci. 2012 Jul;62(4):333-41 - PubMed
  30. Science. 1998 Nov 13;282(5392):1318-21 - PubMed
  31. Transl Stroke Res. 2010 Sep;1(3):202-9 - PubMed
  32. J Immunol. 2001 Aug 15;167(4):1882-5 - PubMed
  33. Mediators Inflamm. 2010;2010:null - PubMed
  34. J Cereb Blood Flow Metab. 2006 Sep;26(9):1114-21 - PubMed
  35. Nat Immunol. 2003 Dec;4(12):1247-53 - PubMed
  36. J Immunol. 2005 Mar 15;174(6):3633-42 - PubMed
  37. Cardiovasc Res. 2004 Apr 1;62(1):74-85 - PubMed
  38. Pharmacol Rep. 2007 Mar-Apr;59(2):192-8 - PubMed
  39. Nat Rev Neurosci. 2006 Jun;7(6):437-48 - PubMed
  40. Science. 2008 Apr 11;320(5873):226-30 - PubMed
  41. Clin Sci (Lond). 2011 Mar;120(6):251-61 - PubMed
  42. Exp Neurol. 2004 Aug;188(2):200-4 - PubMed
  43. J Immunol. 2006 May 15;176(10):6194-201 - PubMed
  44. Curr Opin Immunol. 2003 Feb;15(1):5-11 - PubMed
  45. Proc Natl Acad Sci U S A. 2001 Sep 25;98 (20):11598-603 - PubMed

Publication Types