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Dong R, Hu D, Yang Y, et al. EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway. Oncotarget. 2017;8(31):50958-50971doi: 10.18632/oncotarget.17331.
Dong, R., Hu, D., Yang, Y., Chen, Z., Fu, M., Wang, D. W., Xu, X., & Tu, L. (2017). EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway. Oncotarget, 8(31), 50958-50971. https://doi.org/10.18632/oncotarget.17331
Dong, Ruolan, et al. "EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway." Oncotarget vol. 8,31 (2017): 50958-50971. doi: https://doi.org/10.18632/oncotarget.17331
Dong R, Hu D, Yang Y, Chen Z, Fu M, Wang DW, Xu X, Tu L. EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway. Oncotarget. 2017 Apr 21;8(31):50958-50971. doi: 10.18632/oncotarget.17331. eCollection 2017 Aug 01. PMID: 28881620; PMCID: PMC5584221.
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Oncotarget. 2017 Apr 21;8(31):50958-50971. doi: 10.18632/oncotarget.17331. eCollection 2017 Aug 01.

EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway.

Oncotarget

Ruolan Dong, Danli Hu, Yan Yang, Zhihui Chen, Menglu Fu, Dao Wen Wang, Xizhen Xu, Ling Tu

Affiliations

  1. Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
  2. Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
  3. The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

PMID: 28881620 PMCID: PMC5584221 DOI: 10.18632/oncotarget.17331

Abstract

Integrity of endothelial barrier is a determinant of the prognosis in the acute lung injury caused by sepsis. The epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, exhibit protective effects in various pathogenic states, however, whether EETs play a role in endothelial barrier enhancement and the involved mechanisms remain to be investigated. Here, we show that increased EETs level by endothelial specific cytochrome P450 epoxygenase 2J2 over-expression and soluble epoxide hydrolase (sEH) inhibitor TPPU reduced lipopolysaccharide-induced endothelial hyper-permeability

Keywords: 2J2; CYP450; LPS; Rho-ROCK; vascular permeability

Conflict of interest statement

CONFLICTS OF INTEREST None.

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