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Zhang S, Yeap XY, DeBerge M, et al. Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. JACC Basic Transl Sci. 2017;2(4):386-397doi: 10.1016/j.jacbts.2017.03.013.
Zhang, S., Yeap, X. Y., DeBerge, M., Naresh, N. K., Wang, K., Jiang, Z., Wilcox, J. E., White, S. M., Morrow, J. P., Burridge, P. W., Procissi, D., Scott, E. A., Frazier, W., & Thorp, E. B. (2017). Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. JACC. Basic to translational science, 2(4), 386-397. https://doi.org/10.1016/j.jacbts.2017.03.013
Zhang, Shuang, et al. "Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair." JACC. Basic to translational science vol. 2,4 (2017): 386-397. doi: https://doi.org/10.1016/j.jacbts.2017.03.013
Zhang S, Yeap XY, DeBerge M, Naresh NK, Wang K, Jiang Z, Wilcox JE, White SM, Morrow JP, Burridge PW, Procissi D, Scott EA, Frazier W, Thorp EB. Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. JACC Basic Transl Sci. 2017 Aug;2(4):386-397. doi: 10.1016/j.jacbts.2017.03.013. PMID: 28920097; PMCID: PMC5595371.
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JACC Basic Transl Sci. 2017 Aug;2(4):386-397. doi: 10.1016/j.jacbts.2017.03.013.

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair.

JACC. Basic to translational science

Shuang Zhang, Xin-Yi Yeap, Matthew DeBerge, Nivedita K Naresh, Kevin Wang, Zhengxin Jiang, Jane E Wilcox, Steven M White, John P Morrow, Paul W Burridge, Daniel Procissi, Evan A Scott, William Frazier, Edward B Thorp

Affiliations

  1. Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  2. Columbia University, New York, New York.
  3. Department of Pharmacology and Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  4. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri.

PMID: 28920097 PMCID: PMC5595371 DOI: 10.1016/j.jacbts.2017.03.013

Abstract

Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart.

Keywords: CD47; macrophage; phagocytosis

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