Display options
Share it on

Oncotarget. 2017 May 15;8(37):61083-61092. doi: 10.18632/oncotarget.17854. eCollection 2017 Sep 22.

Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy.

Oncotarget

Leilei Xia, Ye Wang, Ya Chen, Jiuqiong Yan, Fan Hao, Xiaoling Su, Caihong Zhang, Mingjuan Xu

Affiliations

  1. Department of Obstetrics and Gynaecology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
  2. Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
  3. Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.

PMID: 28977848 PMCID: PMC5617408 DOI: 10.18632/oncotarget.17854

Abstract

Cervical carcinoma is one of the main causes of women's cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells

Keywords: AKT/mTOR pathway; cervical cancer; cuprous oxide nanoparticle; nanomedicine; therapy

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflict of interest.

References

  1. Int J Cancer. 2015 Mar 1;136(5):E359-86 - PubMed
  2. Theranostics. 2014 Aug 15;4(11):1085-95 - PubMed
  3. Autophagy. 2007 Nov-Dec;3(6):635-7 - PubMed
  4. Mol Aspects Med. 2004 Aug;25(4):365-451 - PubMed
  5. Small. 2016 Nov;12 (44):6124-6133 - PubMed
  6. Genes Dev. 2007 Nov 15;21(22):2861-73 - PubMed
  7. Br J Haematol. 2017 Jun;177(5):684-702 - PubMed
  8. Autophagy. 2012 Mar;8(3):297-309 - PubMed
  9. Tumour Biol. 2016 Sep;37(9):11541-11551 - PubMed
  10. Acta Pharmacol Sin. 2013 May;34(5):595-9 - PubMed
  11. Nat Rev Clin Oncol. 2016 Dec;13(12 ):750-765 - PubMed
  12. Cell Death Dis. 2013 Aug 29;4:e783 - PubMed
  13. Int J Nanomedicine. 2012;7:2641-52 - PubMed
  14. Acta Pharmacol Sin. 2013 May;34(5):583-4 - PubMed
  15. Brain Res Rev. 2008 Nov;59(1):245-52 - PubMed
  16. Pharmacol Ther. 1997 Oct-Dec;76(1-3):141-9 - PubMed
  17. Int J Dev Biol. 2015;59(1-3):149-58 - PubMed
  18. Cancer Res. 2016 Jul 1;76(13):3872-83 - PubMed
  19. CA Cancer J Clin. 2015 Mar;65(2):87-108 - PubMed
  20. Nat Mater. 2012 Oct;11(10):895-905 - PubMed
  21. Autophagy. 2010 Feb;6(2):239-47 - PubMed
  22. Lancet. 2017 Feb 25;389(10071):847-860 - PubMed
  23. Autophagy. 2007 Nov-Dec;3(6):542-5 - PubMed
  24. Cell. 2006 Jun 30;125(7):1241-52 - PubMed
  25. Autophagy. 2007 Sep-Oct;3(5):452-60 - PubMed
  26. Am J Med Genet C Semin Med Genet. 2016 Dec;172(4):402-421 - PubMed
  27. Methods Mol Biol. 2008;445:77-88 - PubMed
  28. Clin Chem. 2014 Jan;60(1):144-6 - PubMed
  29. Cell Signal. 2014 Dec;26(12):2694-701 - PubMed
  30. Nano Lett. 2012 Apr 11;12(4):1845-50 - PubMed
  31. Acta Biochim Biophys Sin (Shanghai). 2012 May;44(5):375-84 - PubMed
  32. Nanomedicine. 2012 Oct;8(7):1172-81 - PubMed
  33. J Cell Sci. 2012 Jan 15;125(Pt 2):507-15 - PubMed
  34. Biochim Biophys Acta. 2008 Dec;1782(12):691-9 - PubMed

Publication Types