Display options
Cite
González-Fernández B, Sánchez DI, González-Gallego J, et al. Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy. Front Pharmacol. 2017;8:579doi: 10.3389/fphar.2017.00579.
González-Fernández, B., Sánchez, D. I., González-Gallego, J., & Tuñón, M. J. (2017). Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy. Frontiers in pharmacology, 8579. https://doi.org/10.3389/fphar.2017.00579
González-Fernández, Bárbara, et al. "Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy." Frontiers in pharmacology vol. 8 (2017): 579. doi: https://doi.org/10.3389/fphar.2017.00579
González-Fernández B, Sánchez DI, González-Gallego J, Tuñón MJ. Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy. Front Pharmacol. 2017 Aug 25;8:579. doi: 10.3389/fphar.2017.00579. eCollection 2017. PMID: 28890699; PMCID: PMC5574909.
Copy Download .nbib Format: NLM
Share it on

Front Pharmacol. 2017 Aug 25;8:579. doi: 10.3389/fphar.2017.00579. eCollection 2017.

Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy.

Frontiers in pharmacology

Bárbara González-Fernández, Diana I Sánchez, Javier González-Gallego, María J Tuñón

Affiliations

  1. Institute of Biomedicine, University of LeónLeón, Spain.
  2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)León, Spain.

PMID: 28890699 PMCID: PMC5574909 DOI: 10.3389/fphar.2017.00579

Abstract

Liver fibrosis is an excess production of extracellular matrix proteins as a result of chronic liver disease which leads to cell death and organ dysfunction. The key cells involved in fibrogenesis are resident hepatic stellate cells (HSCs) which are termed myofibroblasts after activation, acquiring contractile, proliferative, migratory and secretory capability. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with well-established effects on angiogenesis, carcinogenesis and immunity. Accumulating evidence demonstrates that this metabolite is involved in the profibrotic inflammatory process through the regulation of pleiotropic cell responses, such as vascular permeability, leukocyte infiltration, cell survival, migration, proliferation and HSCs differentiation to myofibroblasts. S1P is synthesized by sphingosine kinases (SphKs) and many of its actions are mediated by S1P specific cell surface receptors (S1P

Keywords: S1P receptors; fibrogenesis; hepatic stellate cells; inhibitors; liver fibrosis; sphingosine 1-phosphate; sphingosine kinases; target therapy

References

  1. Mol Biol Cell. 2010 Mar 15;21(6):1111-24 - PubMed
  2. Dig Liver Dis. 2004 Apr;36(4):231-42 - PubMed
  3. Nat Rev Drug Discov. 2010 Nov;9(11):883-97 - PubMed
  4. J Cell Physiol. 2011 Sep;226(9):2370-7 - PubMed
  5. Cardiovasc Res. 2009 May 1;82(2):303-12 - PubMed
  6. J Biol Chem. 2004 Aug 13;279(33):34343-52 - PubMed
  7. Exp Cell Res. 2017 Mar 15;352(2):420-426 - PubMed
  8. Nat Rev Drug Discov. 2013 Sep;12(9):688-702 - PubMed
  9. J Biol Chem. 2010 Apr 2;285(14 ):10477-86 - PubMed
  10. Biochim Biophys Acta. 2008 Sep;1781(9):467-76 - PubMed
  11. Gene Expr. 2017 Feb 10;17 (2):99-114 - PubMed
  12. Cell Rep. 2015 Dec 1;13(9):1909-1921 - PubMed
  13. Mol Med Rep. 2016 Oct;14 (4):3369-75 - PubMed
  14. J Med Chem. 2017 Jul 13;60(13):5267-5289 - PubMed
  15. Ren Fail. 2013 Aug;35(7):996-1004 - PubMed
  16. Biochim Biophys Acta. 2002 May 23;1582(1-3):121-31 - PubMed
  17. Leukemia. 2016 Nov;30(11):2142-2151 - PubMed
  18. Adv Enzyme Regul. 2010;50(1):349-62 - PubMed
  19. Am J Pathol. 2009 Oct;175(4):1464-72 - PubMed
  20. Biochem Biophys Res Commun. 2002 Dec 6;299(3):483-7 - PubMed
  21. Front Immunol. 2015 Nov 23;6:597 - PubMed
  22. Nat Rev Immunol. 2017 May;17 (5):306-321 - PubMed
  23. J Biol Chem. 2003 Oct 17;278(42):41557-65 - PubMed
  24. J Neurochem. 2007 Dec;103(6):2610-9 - PubMed
  25. Hepatology. 2017 Jun;65(6):2005-2018 - PubMed
  26. Blood. 2013 Aug 1;122(5):791-802 - PubMed
  27. J Hepatol. 2013 Jul;59(1):114-23 - PubMed
  28. Science. 2009 Sep 4;325(5945):1254-7 - PubMed
  29. Reprod Sci. 2014 Feb;21(2):236-43 - PubMed
  30. Ann Intern Med. 2010 Feb 2;152(3):159-66 - PubMed
  31. Prog Lipid Res. 2016 Apr;62:93-106 - PubMed
  32. Redox Biol. 2015 Dec;6:106-11 - PubMed
  33. Thorax. 2015 Dec;70(12):1138-48 - PubMed
  34. Mol Cell Biol. 2005 May;25(10):4237-49 - PubMed
  35. Biochim Biophys Acta. 2013 Jul;1832(7):876-83 - PubMed
  36. J Neurosci. 2011 May 4;31(18):6850-7 - PubMed
  37. Circ Res. 2005 Oct 28;97(9):891-9 - PubMed
  38. Biofactors. 2017 Mar;43(2):272-282 - PubMed
  39. Lancet. 2013 Feb 9;381(9865):468-75 - PubMed
  40. Trends Biochem Sci. 2011 Feb;36(2):97-107 - PubMed
  41. Semin Liver Dis. 2017 Feb;37(1):1-10 - PubMed
  42. Sci Signal. 2015 Aug 11;8(389):ra79 - PubMed
  43. Transplantation. 2013 Apr 15;95(7):919-27 - PubMed
  44. Rev Physiol Biochem Pharmacol. 2008;160:25-46 - PubMed
  45. Thorax. 2015 Dec;70(12):1106-7 - PubMed
  46. Biochim Biophys Acta. 2016 Feb;1861(2):138-147 - PubMed
  47. Sci Rep. 2015 Sep 01;5:13423 - PubMed
  48. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8 - PubMed
  49. Hepatol Res. 2008;38(2):159-65 - PubMed
  50. FASEB J. 2011 Feb;25(2):600-12 - PubMed
  51. J Biol Chem. 2011 Jan 21;286(3):1758-66 - PubMed
  52. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8 - PubMed
  53. Cytokine Growth Factor Rev. 2011 Feb;22(1):45-53 - PubMed
  54. J Biol Chem. 2003 Nov 28;278(48):47408-15 - PubMed
  55. Prostaglandins Other Lipid Mediat. 2006 Jul;80(1-2):74-80 - PubMed
  56. J Cell Biochem. 2004 Aug 1;92(5):913-22 - PubMed
  57. Gastroenterology. 2017 Jul;153(1):233-248.e16 - PubMed
  58. Biochim Biophys Acta. 2006 Dec;1758(12):2016-26 - PubMed
  59. Nature. 2014 Dec 11;516(7530):254-8 - PubMed
  60. Hepatology. 2012 Nov;56(5):1870-82 - PubMed
  61. Hepatology. 2012 Oct;56(4):1427-38 - PubMed
  62. Cell Physiol Biochem. 2010;26(1):79-86 - PubMed
  63. Molecules. 2017 Feb 23;22(3): - PubMed
  64. Clin Exp Pharmacol Physiol. 2005 Mar;32(3):153-61 - PubMed
  65. J Mol Histol. 2013 Dec;44(6):693-703 - PubMed
  66. Mol Cell Endocrinol. 2013 Jan 30;365(2):231-40 - PubMed
  67. Cell Physiol Biochem. 2014;34(1):134-47 - PubMed
  68. Cell Physiol Biochem. 2014;34(1):111-8 - PubMed
  69. J Pineal Res. 2010 Sep;49(2):193-200 - PubMed
  70. Cardiovasc Res. 2009 Jul 15;83(2):285-93 - PubMed
  71. Lab Invest. 2010 Aug;90(8):1209-24 - PubMed
  72. Sci Rep. 2016 Feb 25;6:22141 - PubMed
  73. Biochem J. 2012 May 15;444(1):79-88 - PubMed
  74. Biochem Soc Trans. 2001 Nov;29(Pt 6):836-9 - PubMed
  75. Int J Mol Med. 2017 Feb;39(2):243-252 - PubMed
  76. J Biol Chem. 2000 Jun 16;275(24):18108-13 - PubMed
  77. J Biol Chem. 2012 Nov 16;287(47):39898-910 - PubMed
  78. Sci Rep. 2016 Aug 26;6:32119 - PubMed
  79. Gastroenterology. 2008 May;134(6):1655-69 - PubMed
  80. Nature. 2010 Jun 24;465(7301):1084-8 - PubMed
  81. J Nutr. 2010 Jun;140(6):1065-71 - PubMed
  82. J Clin Invest. 2012 Apr;122(4):1416-26 - PubMed
  83. Biomol Ther (Seoul). 2017 Jan 1;25(1):80-90 - PubMed
  84. Trends Mol Med. 2017 Apr;23 (4):362-374 - PubMed
  85. J Pineal Res. 2013 Oct;55(3):221-8 - PubMed
  86. Hepatology. 2012 Dec;56(6):2316-27 - PubMed
  87. Am J Pathol. 2017 Jan;187(1):134-145 - PubMed
  88. J Biol Chem. 2002 Jun 28;277(26):23294-300 - PubMed
  89. Nat Rev Mol Cell Biol. 2003 May;4(5):397-407 - PubMed
  90. Sci China Life Sci. 2017 Jun;60(6):585-600 - PubMed
  91. Hepatology. 2010 Apr;51(4):1345-53 - PubMed
  92. J Pineal Res. 2014 Jan;56(1):20-30 - PubMed
  93. Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G304-10 - PubMed
  94. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9 - PubMed
  95. Hepatology. 2012 Aug;56(2):532-43 - PubMed
  96. J Pineal Res. 2015 Oct;59(3):391-401 - PubMed
  97. Trends Cell Biol. 2012 Jan;22(1):50-60 - PubMed
  98. Biochem Biophys Res Commun. 2004 Jul 30;320(3):754-9 - PubMed
  99. Oncotarget. 2015 May 30;6(15):13803-21 - PubMed
  100. J Mol Med (Berl). 2017 Jan;95(1):69-82 - PubMed
  101. J Biol Chem. 2002 Oct 4;277(40):37323-30 - PubMed
  102. Nutrients. 2017 Mar 16;9(3):null - PubMed
  103. Hepatology. 2006 Feb;43(2 Suppl 1):S82-8 - PubMed
  104. Mediators Inflamm. 2016;2016:7629724 - PubMed
  105. J Pineal Res. 2017 Jan;62(1): - PubMed
  106. Gut. 2012 Nov;61(11):1600-9 - PubMed
  107. Biomed Res Int. 2014;2014:869390 - PubMed
  108. J Hepatol. 2009 Jun;50(6):1174-83 - PubMed
  109. FASEB J. 2015 Nov;29(11):4654-69 - PubMed
  110. J Pineal Res. 2016 Mar;60(2):121-31 - PubMed
  111. Biochim Biophys Acta. 2013 Jan;1831(1):239-50 - PubMed
  112. EMBO Mol Med. 2012 Aug;4(8):761-75 - PubMed
  113. FEBS Lett. 2000 Jun 30;476(1-2):55-7 - PubMed
  114. Nat Med. 2013 Dec;19(12):1617-24 - PubMed
  115. Fibrogenesis Tissue Repair. 2008 Oct 13;1(1):5 - PubMed
  116. Science. 2001 Mar 2;291(5509):1800-3 - PubMed
  117. J Lipid Res. 2009 Mar;50(3):556-64 - PubMed
  118. PLoS One. 2012;7(7):e41394 - PubMed
  119. Biochim Biophys Acta. 2008 Mar;1783(3):347-59 - PubMed
  120. World J Gastroenterol. 2016 Dec 28;22(48):10512-10522 - PubMed
  121. Oncotarget. 2016 Apr 5;7(14 ):18095-105 - PubMed
  122. Cell Physiol Biochem. 2016;40(6):1637-1645 - PubMed
  123. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G300-G313 - PubMed
  124. Tumour Biol. 2016 Aug;37(8):10587-93 - PubMed
  125. Gastroenterology. 2010 Oct;139(4):1375-84 - PubMed
  126. Am J Pathol. 2012 Jul;181(1):85-97 - PubMed
  127. J Pineal Res. 2014 Apr;56(3):313-21 - PubMed
  128. Eur J Pharmacol. 2016 Apr 5;776:19-25 - PubMed
  129. Biochemistry. 1989 Aug 22;28(17):6796-800 - PubMed
  130. Nat Chem Biol. 2006 Aug;2(8):434-41 - PubMed
  131. Oncotarget. 2017 May 30;8(22):36898-36929 - PubMed
  132. Front Physiol. 2013 Nov 25;4:338 - PubMed
  133. JCI Insight. 2016 Dec 22;1(21):e87058 - PubMed
  134. J Pineal Res. 2015 Sep;59(2):151-62 - PubMed
  135. Anticancer Agents Med Chem. 2017 Feb 13;:null - PubMed
  136. Am J Respir Cell Mol Biol. 2007 Oct;37(4):395-404 - PubMed
  137. Gastroenterology. 2012 Apr;142(4):938-46 - PubMed
  138. Nat Med. 2012 Jul 06;18(7):1028-40 - PubMed
  139. Curr Atheroscler Rep. 2016 Jun;18(6):31 - PubMed
  140. Biomed Res Int. 2017;2017:2067479 - PubMed
  141. Biochim Biophys Acta. 2013 Jan;1831(1):185-92 - PubMed
  142. Arch Biochem Biophys. 2014 Apr 15;548:20-37 - PubMed
  143. World J Gastroenterol. 2014 Mar 14;20(10):2515-32 - PubMed
  144. J Pineal Res. 2017 May;62(4):null - PubMed
  145. J Pineal Res. 2016 Sep;61(2):168-76 - PubMed
  146. Gut. 2015 May;64(5):830-41 - PubMed
  147. FASEB J. 2013 Aug;27(8):3155-66 - PubMed
  148. Hepatology. 2017 Feb;65(2):694-709 - PubMed
  149. Biochem Biophys Res Commun. 2006 Jun 23;345(1):85-92 - PubMed
  150. J Mol Med (Berl). 2010 Apr;88(4):401-11 - PubMed
  151. Am J Pathol. 2015 Feb;185(2):387-98 - PubMed
  152. Circ Heart Fail. 2013 Jul;6(4):833-44 - PubMed
  153. IUBMB Life. 2016 May;68(5):376-87 - PubMed
  154. J Hepatol. 2015 Apr;62(1 Suppl):S15-24 - PubMed
  155. J Hepatol. 2011 Jun;54(6):1205-13 - PubMed
  156. Adv Biol Regul. 2015 Jan;57:55-63 - PubMed
  157. J Physiol Biochem. 2012 Mar;68(1):29-35 - PubMed
  158. Nat Rev Immunol. 2014 Mar;14(3):181-94 - PubMed
  159. Biochim Biophys Acta. 2013 Jan;1831(1):228-38 - PubMed
  160. Inflammation. 2014 Aug;37(4):1326-36 - PubMed
  161. Clin Res Hepatol Gastroenterol. 2014 Feb;38(1):63-72 - PubMed
  162. Semin Liver Dis. 2015 May;35(2):184-98 - PubMed
  163. Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50 - PubMed
  164. Cell Signal. 2011 Nov;23(11):1831-42 - PubMed
  165. J Formos Med Assoc. 2015 Sep;114(9):860-4 - PubMed
  166. Drug Des Devel Ther. 2013 Jun 28;7:553-63 - PubMed
  167. Nat Rev Immunol. 2008 Oct;8(10):753-63 - PubMed

Publication Types