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Gadzinski JA, Guo J, Philips BJ, et al. Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice. Adv Biol Chem. 2016;6(6):193-215doi: 10.4236/abc.2016.66017.
Gadzinski, J. A., Guo, J., Philips, B. J., Basse, P., Craig, E. K., Bailey, L., Comerci, J. T., & Eiseman, J. L. (2016). Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice. Advances in biological chemistry, 6(6), 193-215. https://doi.org/10.4236/abc.2016.66017
Gadzinski, Jill A, et al. "Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice." Advances in biological chemistry vol. 6,6 (2016): 193-215. doi: https://doi.org/10.4236/abc.2016.66017
Gadzinski JA, Guo J, Philips BJ, Basse P, Craig EK, Bailey L, Comerci JT, Eiseman JL. Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice. Adv Biol Chem. 2016 Dec;6(6):193-215. doi: 10.4236/abc.2016.66017. Epub 2016 Dec 30. PMID: 28890844; PMCID: PMC5589197.
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Adv Biol Chem. 2016 Dec;6(6):193-215. doi: 10.4236/abc.2016.66017. Epub 2016 Dec 30.

Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice.

Advances in biological chemistry

Jill A Gadzinski, Jianxia Guo, Brian J Philips, Per Basse, Ethan K Craig, Lisa Bailey, John T Comerci, Julie L Eiseman

Affiliations

  1. Magee Women's Hospital of the University of Pittsburgh, Department of Obstetrics/Gynecology/Reproductive Sciences, 300 Halket Street, Pittsburgh, USA, 15213.
  2. Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, and Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 5117 Centre Ave., Pittsburgh, PA 15213.
  3. Cancer Immunology Program, University of Pittsburgh Cancer Institute, and Department of Immunology, School of Medicine, University of Pittsburgh, 5117 Centre Ave. Pittsburgh, PA 15213.
  4. School of Medicine, Unversity of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA 15232.

PMID: 28890844 PMCID: PMC5589197 DOI: 10.4236/abc.2016.66017

Abstract

BACKGROUND: Cervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy using Pc 4 in vitro and in vivo against human cervical cancer cells.

METHODS: CaSki and ME-180 cancer cells were grown as monolayers and spheroids. Cell growth and cytotoxicity were measured using a methylthiazol tetrazolium assay. Pc 4 cellular uptake and intracellular distrubtion were determined. For in vitro Pc 4 photodynamic therapy cells were irradiated at 667nm at a fluence of 2.5 J/cm

RESULTS: The IC

CONCLUSIONS: Pc 4 photodynamic therapy caused death within cervical cancer cells and xenografts, supporting development of Pc 4 photodynamic therapy for treatment of cervical cancer. Support: P30-CA47904, CTSI BaCCoR Pilot Program.

Keywords: Silicon Phthalocyanine 4; cervical cancer; lasers; photodynamic therapy

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