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Showing 1 to 12 of 195 entries
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Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells In Vitro and in Mice.

Advances in biological chemistry

Gadzinski JA, Guo J, Philips BJ, Basse P, Craig EK, Bailey L, Comerci JT, Eiseman JL.
PMID: 28890844
Adv Biol Chem. 2016 Dec;6(6):193-215. doi: 10.4236/abc.2016.66017. Epub 2016 Dec 30.

BACKGROUND: Cervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy...

Murine Bronchoalveolar Lavage.

Bio-protocol

Sun F, Xiao G, Qu Z.
PMID: 29082285
Bio Protoc. 2017 May 20;7(10). doi: 10.21769/BioProtoc.2287.

A basic Bronchoalveolar lavage (BAL) procedure in mouse is described here. Cells and fluids obtained from BAL can be analyzed by Hema3-staining, immunostaining, Fluorescence-activated cell sorting (FACS), PCR, bicinchoninic acid protein assay, enzyme-linked immunosorbent assay (ELISA), luminex assays,

In vivo inflammation imaging using a CB2R-targeted near infrared fluorescent probe.

American journal of nuclear medicine and molecular imaging

Zhang S, Shao P, Ling X, Yang L, Hou W, Thorne SH, Beaino W, Anderson CJ, Ding Y, Bai M.
PMID: 26069858
Am J Nucl Med Mol Imaging. 2015 Feb 15;5(3):246-58. eCollection 2015.

Chronic inflammation is considered as a critical cause of a host of disorders, such as cancer, rheumatoid arthritis, atherosclerosis, and neurodegenerative diseases, although the exact mechanism is yet to be explored. Imaging tools that can specifically target inflammation are...

Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction.

Journal for immunotherapy of cancer

Muthuswamy R, Wang L, Pitteroff J, Gingrich JR, Kalinski P.
PMID: 25806105
J Immunother Cancer. 2015 Mar 24;3:6. doi: 10.1186/s40425-015-0050-8. eCollection 2015.

BACKGROUND: BCG is a prototypal cancer immunotherapeutic factor currently approved of bladder cancer. In attempt to further enhance the effectiveness of immunotherapy of bladder cancer and, potentially, other malignancies, we evaluated the impact of BCG on local production of...

Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease.

Frontiers in immunology

Whiteside TL, Jackson EK.
PMID: 23898333
Front Immunol. 2013 Jul 25;4:212. doi: 10.3389/fimmu.2013.00212. eCollection 2013.

Regulatory T cells (Treg) play a key role in maintaining the balance of immune responses in human health and in disease. Treg come in many flavors and can utilize a variety of mechanisms to modulate immune responses. In cancer,...

Behavioral patterns associated with chemotherapy-induced emesis: a potential signature for nausea in musk shrews.

Frontiers in neuroscience

Horn CC, Henry S, Meyers K, Magnusson MS.
PMID: 21808604
Front Neurosci. 2011 Jul 14;5:88. doi: 10.3389/fnins.2011.00088. eCollection 2011.

Nausea and vomiting are common symptoms in patients with many diseases, including cancer and its treatments. Although the neurological basis of vomiting is reasonably well known, an understanding of the physiology of nausea is lacking. The primary barrier to...

Reply to V. Launay-Vacher, T. Shimokata et al, and C. Porta et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Beumer JH, Tawbi H, Ivy SP.
PMID: 27185845
J Clin Oncol. 2016 Jul 10;34(20):2430-1. doi: 10.1200/JCO.2016.67.2790. Epub 2016 May 16.

No abstract available.

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.

Frontiers in immunology

Thomson AW, Zahorchak AF, Ezzelarab MB, Butterfield LH, Lakkis FG, Metes DM.
PMID: 26858719
Front Immunol. 2016 Jan 28;7:15. doi: 10.3389/fimmu.2016.00015. eCollection 2016.

Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transplantation can be generated in vitro under...

Mass Balance Study of the Engineered Cationic Antimicrobial Peptide, WLBU2, Following a Single Intravenous Dose of 14C-WLBU2 in Mice.

Current reviews in clinical and experimental pharmacology

Beumer JH, Guo J, Ray EC, Scemama J, Parise RA, Deslouches B, Steckbeck JD, Montelaro RC, Eiseman JL.
PMID: 32778037
Curr Rev Clin Exp Pharmacol. 2021;16(3):263-272. doi: 10.2174/1574884715666200810094201.

BACKGROUND: To address multidrug resistance, we developed engineered Cationic Antimicrobial Peptides (eCAPs). Lead eCAP WLBU2 displays potent activity against drug-resistant bacteria and effectively treats lethal bacterial infections in mice, reducing bacterial loads to undetectable levels in diverse organs.OBJECTIVE: To...

EAF2 loss induces prostatic intraepithelial neoplasia from luminal epithelial cells in mice.

American journal of clinical and experimental urology

Pascal LE, Rigatti LH, Ai J, Zhang A, Zhou J, Nelson JB, Wang Z.
PMID: 32211450
Am J Clin Exp Urol. 2020 Feb 25;8(1):18-27. eCollection 2020.

Defining the cell of origin for prostatic carcinogenesis is fundamentally important for understanding the mechanisms leading to prostate cancer. Lineage tracing studies have demonstrated that luminal epithelial cells are capable of self-replication in multiple organs, including the adult murine...

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors.

Cell reports

Molina LM, Zhu J, Li Q, Pradhan-Sundd T, Krutsenko Y, Sayed K, Jenkins N, Vats R, Bhushan B, Ko S, Hu S, Poddar M, Singh S, Tao J, Sundd P, Singhi A, Watkins S, Ma X, Benos PV, Feranchak A, Michalopoulos G, Nejak-Bowen K, Watson A, Bell A, Monga SP.
PMID: 34233187
Cell Rep. 2021 Jul 06;36(1):109310. doi: 10.1016/j.celrep.2021.109310.

Yes-associated protein 1 (YAP1) regulates cell plasticity during liver injury, regeneration, and cancer, but its role in liver development is unknown. We detect YAP1 activity in biliary cells and in cells at the hepatobiliary bifurcation in single-cell RNA sequencing...

Perceived physical fatigability improves after an exercise intervention among breast cancer survivors: a randomized clinical trial.

Breast cancer (Tokyo, Japan)

Qiao Y, van Londen GJ, Brufsky JW, Poppenberg JT, Cohen RW, Boudreau RM, Glynn NW.
PMID: 34328623
Breast Cancer. 2021 Jul 30; doi: 10.1007/s12282-021-01278-1. Epub 2021 Jul 30.

BACKGROUND: Among breast cancer populations, exercise interventions resulted in positive but relatively small improvements on fatigue, which may be due to insensitive measures of global fatigue. Perceived fatigability-whole-body tiredness anchored to standardized tasks/activities of a specific intensity and duration-may...

Showing 1 to 12 of 195 entries