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Tanaka H, Yamaguchi T, Hachiya K, et al. Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone. Rep Pract Oncol Radiother. 2017;22(6):477-481doi: 10.1016/j.rpor.2017.08.009.
Tanaka, H., Yamaguchi, T., Hachiya, K., Hayashi, M., Ogawa, S., Nishibori, H., Kamei, S., Ishihara, S., Matsuo, M., & Kellam, S. G. (2017). Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 22(6), 477-481. https://doi.org/10.1016/j.rpor.2017.08.009
Tanaka, Hidekazu, et al. "Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone." Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology vol. 22,6 (2017): 477-481. doi: https://doi.org/10.1016/j.rpor.2017.08.009
Tanaka H, Yamaguchi T, Hachiya K, Hayashi M, Ogawa S, Nishibori H, Kamei S, Ishihara S, Matsuo M, Kellam SG. Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone. Rep Pract Oncol Radiother. 2017 Nov-Dec;22(6):477-481. doi: 10.1016/j.rpor.2017.08.009. Epub 2017 Sep 19. PMID: 28951699; PMCID: PMC5607145.
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Rep Pract Oncol Radiother. 2017 Nov-Dec;22(6):477-481. doi: 10.1016/j.rpor.2017.08.009. Epub 2017 Sep 19.

Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Masahide Hayashi, Shinichi Ogawa, Hironori Nishibori, Shingo Kamei, Satoshi Ishihara, Masayuki Matsuo, Kellam

Affiliations

  1. Department of Radiology, Gifu University, Yanagido 1-1, Gifu 501-1194, Japan.
  2. Department of Radiation Oncology, Kizawa Memorial Hospital, Shimokobi 590, Kobicho, Minokamo 505-8503, Japan.
  3. Department of Urology, Kizawa Memorial Hospital, Shimokobi 590, Kobicho, Minokamo 505-8503, Japan.

PMID: 28951699 PMCID: PMC5607145 DOI: 10.1016/j.rpor.2017.08.009

Abstract

AIM: To assess the changes in prostate size in patients with prostate cancer undergoing intensity-modulated radiation therapy (IMRT).

BACKGROUND: The effect of size change produced by IMRT is not well known.

MATERIALS AND METHODS: We enrolled 72 patients who received IMRT alone without androgen-deprivation therapy and underwent magnetic resonance imaging (MRI) examination before and after IMRT. The diameter of the entire prostate in the anterior-posterior (P-AP) and left-right (P-LR) directions was measured. The transitional zone diameter in the anterior-posterior (T-AP) and left-right (T-LR) directions was also measured.

RESULTS: The average relative P-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.94, 0.90, 0.89, 0.89, and 0.90, respectively; the average relative P-LR values were 0.93, 0.92, 0.91, 0.91, and 0.90, respectively. The average P-AP and P-LR decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. The average relative T-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.93, 0.88, 0.91, 0.87, and 0.89, respectively; the average relative T-LR values were 0.96, 0.90, 0.91, 0.87, and 0.88, respectively. The average T-AP and T-LR also decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. At 12 months after IMRT, the average relative T-AP was significantly lower in patients with recurrence than in those without recurrence.

CONCLUSIONS: The average prostate diameter decreased by approximately 10% during the 12 months after IMRT; thereafter remained unchanged.

Keywords: External beam radiation therapy; Intensity-modulated radiation therapy; Magnetic resonance imaging; Prostate cancer

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