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Nemtsova MV, Strelnikov VV, Tanas AS, et al. Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice. Curr Genomics. 2017;18(5):408-415doi: 10.2174/1389202918666170329110021.
Nemtsova, M. V., Strelnikov, V. V., Tanas, A. S., Bykov, I. I., Zaletaev, D. V., Rudenko, V. V., Glukhov, A. I., Kchorobrich, T. V., Li, Y., Tarasov, V. V., Barreto, G. E., & Aliev, G. (2017). Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice. Current genomics, 18(5), 408-415. https://doi.org/10.2174/1389202918666170329110021
Nemtsova, Marina V, et al. "Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice." Current genomics vol. 18,5 (2017): 408-415. doi: https://doi.org/10.2174/1389202918666170329110021
Nemtsova MV, Strelnikov VV, Tanas AS, Bykov II, Zaletaev DV, Rudenko VV, Glukhov AI, Kchorobrich TV, Li Y, Tarasov VV, Barreto GE, Aliev G. Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice. Curr Genomics. 2017 Oct;18(5):408-415. doi: 10.2174/1389202918666170329110021. PMID: 29081696; PMCID: PMC5635646.
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Curr Genomics. 2017 Oct;18(5):408-415. doi: 10.2174/1389202918666170329110021.

Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice.

Current genomics

Marina V Nemtsova, Vladimir V Strelnikov, Alexander S Tanas, Igor I Bykov, Dmitry V Zaletaev, Viktoria V Rudenko, Alexander I Glukhov, Tatiana V Kchorobrich, Yi Li, Vadim V Tarasov, George E Barreto, Gjumrakch Aliev

Affiliations

  1. Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya St. 8/2, Moscow, 119991, Russian Federation.
  2. Department of Medical Genetics, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow, 119991, Russian Federation.
  3. Research Centre for Medical Genetics, Moskvorechie St. 1, 115472, Moscow, Russia.
  4. Department No 1, Medical Faculty, Faculty Surgery, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya St. 8/2, Moscow, 119991, Russian Federation.
  5. Department of Biochemistry, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya, 8/2, Moscow, 119991, Russian Federation.
  6. National Research Centre "Kurchatov Institute", Moscow, 123182, Russia.
  7. Department of Human Sciences, Texas A&M University-Kingsville, TX 78363, USA.
  8. Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 119991Moscow, Russia.
  9. Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, BogotáD.C., Colombia.
  10. "GALLY" International Biomedical Research Consulting LLC, San Antonio, TX78229, USA.
  11. School of Health Sciences, University of Atlanta, Johns Creek, GA 30097, USA.
  12. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432, Russia.

PMID: 29081696 PMCID: PMC5635646 DOI: 10.2174/1389202918666170329110021

Abstract

INTRODUCTION: We have investigated aberrant methylation of genes CDH1, RASSF1A, MLH1, N33, DAPK, expression of genes hTERT, MMP7, MMP9, BIRC5 (survivin), PTGS2, and activity of telomerase of 106 gastric tumor samples obtained intra-operatively and 53 gastric tumor samples from the same group of patients obtained endoscopically before surgery. Biopsy specimens obtained from 50 patients with chronic calculous cholecystitis were used as a control group. Together with tissue samples obtained from different sites remote to tumors, a total of 727 samples have been studied. The selected parameters comprise a system of molecular markers that can be used in both diagnostics of gastric cancer and in dynamic monitoring of patients after surgery. Special attention was paid to the use of molecular markers for the diagnostics of malignant process in the material obtained endoscopically since the efficacy of morphological diagnostics in biopsies is compromised by intratumoral heterogeneity, which may prevent reliable identification of tumor cells in the sampling. Our data indicated that certain molecular genetic events provided more sensitive yet specific markers of the tumor.

CONCLUSION: We demonstrated that molecular profiles detected in preoperative biopsies were confirmed by the material obtained intra-operatively. The use of endoscopic material facilitates gastric tumors pre-operative diagnostics, improving early detection of gastric cancer and potential effective treatment strategies.

Keywords: Biopsies; Gastric cancer; Genetic markers; Heterogeneous; Molecular profiles; Treatment

References

  1. Mol Biol (Mosk). 2003 Nov-Dec;37(6):983-8 - PubMed
  2. Gene. 2002 Sep 4;297(1-2):103-12 - PubMed
  3. Br J Cancer. 2014 Aug 12;111(4):749-55 - PubMed
  4. Clin Cancer Res. 2002 Jan;8(1):144-8 - PubMed
  5. World J Gastroenterol. 2011 Jan 21;17(3):290-9 - PubMed
  6. Anticancer Res. 2006 Sep-Oct;26(5A):3579-83 - PubMed
  7. Acta Pathol Microbiol Scand. 1965;64:31-49 - PubMed
  8. Hum Pathol. 2006 Jan;37(1):16-22 - PubMed
  9. Gene. 2014 Oct 15;550(1):27-32 - PubMed
  10. Eur J Cancer. 2015 May;51(8):969-76 - PubMed
  11. Biochem Biophys Res Commun. 1998 Jul 20;248(2):368-71 - PubMed
  12. Nat Rev Cancer. 2004 Dec;4(12 ):988-93 - PubMed
  13. Pathol Int. 2003 Oct;53(10 ):659-66 - PubMed
  14. J Surg Oncol. 2013 Mar;107(3):237-42 - PubMed
  15. Exp Ther Med. 2013 Jan;5(1):305-307 - PubMed
  16. Int J Cancer. 2008 Feb 1;122(3):603-8 - PubMed
  17. Nanomedicine. 2010 Jun;6(3):427-41 - PubMed
  18. Pathobiology. 2011;78(6):302-10 - PubMed
  19. Asian Pac J Cancer Prev. 2013;14(2):679-83 - PubMed
  20. Cancer Biomark. 2013;13(1):21-8 - PubMed
  21. World J Gastroenterol. 2004 Dec 1;10(23):3441-54 - PubMed
  22. Science. 2002 Mar 29;295(5564):2387-92 - PubMed
  23. Eur J Cancer. 2009 May;45(7):1282-93 - PubMed
  24. In Vivo. 2005 Sep-Oct;19(5):943-8 - PubMed
  25. Oncol Rep. 2009 Feb;21(2):507-13 - PubMed
  26. Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):145-52 - PubMed
  27. Cancer Epidemiol Biomarkers Prev. 2013 Sep;22(9):1490-7 - PubMed
  28. Clin Cancer Res. 2004 Dec 15;10(24):8243-9 - PubMed
  29. Cancer Gene Ther. 2015 Apr;22(3):101-7 - PubMed
  30. Pathobiology. 2014;81(1):36-41 - PubMed
  31. Cancers (Basel). 2011 Oct 14;3(4):3894-908 - PubMed
  32. Cell Res. 2005 Apr;15(4):247-54 - PubMed
  33. World J Gastroenterol. 2007 May 28;13(20):2784-90 - PubMed

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