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Shi J, Deng Q, Wan C, et al. Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE). Chem Sci. 2017;8(9):6188-6195doi: 10.1039/c7sc02189e.
Shi, J., Deng, Q., Wan, C., Zheng, M., Huang, F., & Tang, B. (2017). Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE). Chemical science, 8(9), 6188-6195. https://doi.org/10.1039/c7sc02189e
Shi, Jie, et al. "Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE)." Chemical science vol. 8,9 (2017): 6188-6195. doi: https://doi.org/10.1039/c7sc02189e
Shi J, Deng Q, Wan C, Zheng M, Huang F, Tang B. Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE). Chem Sci. 2017 Sep 01;8(9):6188-6195. doi: 10.1039/c7sc02189e. Epub 2017 Jun 23. PMID: 28989651; PMCID: PMC5628346.
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Chem Sci. 2017 Sep 01;8(9):6188-6195. doi: 10.1039/c7sc02189e. Epub 2017 Jun 23.

Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE).

Chemical science

Jie Shi, Qianchun Deng, Chuyun Wan, Mingming Zheng, Fenghong Huang, Bo Tang

Affiliations

  1. Hubei Key Laboratory of Lipid Chemistry and Nutrition , Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory , Key Laboratory of Oilseeds Processing , Ministry of Agriculture , Oil Crops Research Institute , Chinese Academy of Agricultural Sciences , Wuhan 430062 , China . Email: [email protected].
  2. College of Chemistry , Chemical Engineering and Materials Science , Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong , Key Laboratory of Molecular and Nano Probes , Ministry of Education , Shandong Normal University , Jinan 250014 , China . Email: [email protected].

PMID: 28989651 PMCID: PMC5628346 DOI: 10.1039/c7sc02189e

Abstract

As a sudden inflammation of the pancreas, acute pancreatitis presents severe complications and a high mortality rate, despite treatment. Lipase in serum serves as an essential biomarker of acute pancreatitis and even pancreatic cancer. Therefore, developing robust, convenient and sensitive probing of lipase levels is greatly needed. In this work, we present glutamate functionalized tetraphenylethylene (TPE) as a "turn-on" fluorescent probe (

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