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Yoon NA, Park J, Lee J, et al. Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet. Dev Reprod. 2017;21(3):259-267doi: 10.12717/DR.2017.21.3.259.
Yoon, N. A., Park, J., Lee, J., Jeong, J. Y., Kim, H. K., Lee, H. S., Hwang, I. G., Roh, G. S., Kim, H. J., Cho, G. J., Choi, W. S., Lee, D. H., & Kang, S. S. (2017). Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet. Development & reproduction, 21(3), 259-267. https://doi.org/10.12717/DR.2017.21.3.259
Yoon, Nal Ae, et al. "Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet." Development & reproduction vol. 21,3 (2017): 259-267. doi: https://doi.org/10.12717/DR.2017.21.3.259
Yoon NA, Park J, Lee J, Jeong JY, Kim HK, Lee HS, Hwang IG, Roh GS, Kim HJ, Cho GJ, Choi WS, Lee DH, Kang SS. Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet. Dev Reprod. 2017 Sep;21(3):259-267. doi: 10.12717/DR.2017.21.3.259. Epub 2017 Sep 30. PMID: 29082341; PMCID: PMC5651692.
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Dev Reprod. 2017 Sep;21(3):259-267. doi: 10.12717/DR.2017.21.3.259. Epub 2017 Sep 30.

Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet.

Development & reproduction

Nal Ae Yoon, Juyeong Park, Jiyeon Lee, Joo Yeon Jeong, Hyun-Kyu Kim, Hak Sung Lee, In Guk Hwang, Gu Seob Roh, Hyun Joon Kim, Gyeong Jae Cho, Wan Sung Choi, Dong Hoon Lee, Sang Soo Kang

Affiliations

  1. Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.
  2. Nutraceutical Food R&D Center, KolmarBNH Co., Ltd., Sejong 30003, Korea.
  3. Dept. of Agrofood Resources, National Academy of Agricultural Science, Rural Development Administration, Wanju 55365, Korea.

PMID: 29082341 PMCID: PMC5651692 DOI: 10.12717/DR.2017.21.3.259

Abstract

Present study aimed to determine the effect of 'bitter melon', a popularly used fruit in Bangladesh and several other Asian countries, on high-fat-diet-induced type 2 diabetes. To investigate the effect, ethanol extract from bitter melon (BME) as a dietary supplement with mouse chow was used. BME was found to significantly attenuate the high-fat diet (HFD) -induced body weight and total fat mass. BME also effectively reduced the insulin resistance induced by the HFD. Furthermore, dietary supplementation of BME was highly effective in increasing insulin sensitivity and reducing hepatic fat and obesity. These results indicate that BME could be effective in attenuating type 2 diabetes and could therefore be a preventive measure against type 2 diabetes.

Keywords: Bitter melon; Ethanol extract; High-fat diet; Obesity; Sirtuin 1; Type 2 diabetes

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. Genes Dev. 2010 Jul 1;24(13):1403-17 - PubMed
  2. Endocrinology. 2003 Dec;144(12):5159-65 - PubMed
  3. Diabetes Metab J. 2013 Oct;37(5):315-25 - PubMed
  4. J Nutr. 2003 Apr;133(4):1088-93 - PubMed
  5. J Lipids. 2015;2015:496169 - PubMed
  6. Nature. 2005 Mar 3;434(7029):113-8 - PubMed
  7. Am J Med Sci. 2017 Jan;353(1):1-5 - PubMed
  8. Pharm Biol. 2017 Dec;55(1):758-765 - PubMed
  9. Int J Biol Sci. 2011;7(5):575-87 - PubMed
  10. Cell Cycle. 2008 Dec;7(23):3669-79 - PubMed
  11. Endocrinol Metab Clin North Am. 2008 Dec;37(4):841-56 - PubMed
  12. Mol Metab. 2015 Mar 05;4(5):378-91 - PubMed
  13. Chem Biol. 2008 Mar;15(3):263-73 - PubMed
  14. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8 - PubMed
  15. Ceska Slov Farm. 2015 Sep;64(4):126-32 - PubMed
  16. Int J Environ Res Public Health. 2014 Feb 21;11(2):2328-45 - PubMed
  17. Public Health Nutr. 2004 Feb;7(1A):147-65 - PubMed
  18. J Agric Food Chem. 2013 Mar 13;61(10):2461-8 - PubMed
  19. J Cardiometab Syndr. 2009 Spring;4(2):113-9 - PubMed
  20. Diabetes. 2010 Apr;59(4):1006-15 - PubMed
  21. Asian Pac J Trop Biomed. 2012 Apr;2(4):320-30 - PubMed
  22. Acta Biochim Biophys Sin (Shanghai). 2013 Jan;45(1):51-60 - PubMed
  23. J Diabetes Metab Disord. 2012 Oct 01;11(1):17 - PubMed
  24. Physiol Behav. 2010 Apr 26;100(1):47-54 - PubMed
  25. Phys Ther. 2008 Nov;88(11):1254-64 - PubMed
  26. Am J Clin Nutr. 2008 May;87(5):1212-8 - PubMed

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