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J Antibiot (Tokyo). 2017 Oct 11; doi: 10.1038/ja.2017.115. Epub 2017 Oct 11.

Current landscape and future prospects of antiviral drugs derived from microbial products.

The Journal of antibiotics

Naoki Takizawa, Manabu Yamasaki

Affiliations

  1. Laboratory of Virology, Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan.

PMID: 29018267 PMCID: PMC7091927 DOI: 10.1038/ja.2017.115

Abstract

Viral infections are a major global health threat. Over the last 50 years, significant efforts have been devoted to the development of antiviral drugs and great success has been achieved for some viruses. However, other virus infections, such as epidemic influenza, still spread globally and new threats continue to arise from emerging and re-emerging viruses and drug-resistant viruses. In this review, the contributions of microbial products isolated in Institute of Microbial Chemistry for antiviral research are summarized. In addition, the current state of development of antiviral drugs that target influenza virus and hepatitis B virus, and the future prospects for antivirals from natural products are described and discussed.The Journal of Antibiotics advance online publication, 11 October 2017; doi:10.1038/ja.2017.115.

References

  1. J Antibiot (Tokyo). 1996 Jan;49(1):113-8 - PubMed
  2. Antiviral Res. 2017 Jun;142:63-67 - PubMed
  3. J Antibiot (Tokyo). 2002 Feb;55(2):165-71 - PubMed
  4. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8351-5 - PubMed
  5. J Antibiot (Tokyo). 1981 Sep;34(9):1219-21 - PubMed
  6. Science. 1964 May 15;144(3620):862-3 - PubMed
  7. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92 - PubMed
  8. Clin Exp Immunol. 1998 Jan;111(1):30-5 - PubMed
  9. Nat Prod Rep. 2012 Jan;29(1):11-36 - PubMed
  10. J Virol. 1990 Jun;64(6):2819-24 - PubMed
  11. Antiviral Res. 2016 Jan;125:25-33 - PubMed
  12. Biochemistry. 1994 Jul 12;33(27):8172-9 - PubMed
  13. J Med Virol. 2014 Jun;86(6):925-32 - PubMed
  14. J Gen Virol. 2012 Apr;93(Pt 4):722-32 - PubMed
  15. Immunopharmacology. 2000 May;47(2-3):119-25 - PubMed
  16. J Antibiot (Tokyo). 1974 Dec;27(12):963-9 - PubMed
  17. J Virol. 2007 Nov;81(22):12111-8 - PubMed
  18. Science. 1990 Apr 20;248(4953):358-61 - PubMed
  19. Antimicrob Agents Chemother. 2015 Feb;59(2):1070-9 - PubMed
  20. Hepatology. 2014 May;59(5):1726-37 - PubMed
  21. Antiviral Res. 2014 Apr;104:153-5 - PubMed
  22. J Antibiot (Tokyo). 1974 Oct;27(10):801-4 - PubMed
  23. J Antibiot (Tokyo). 1993 Dec;46(12):1883-9 - PubMed
  24. Intervirology. 2011;54(4):202-16 - PubMed
  25. Biochem Soc Trans. 2017 Apr 15;45(2):571-582 - PubMed
  26. J Virol. 2012 Sep;86(18):9875-87 - PubMed
  27. J Antibiot (Tokyo). 1991 May;44(5):569-71 - PubMed
  28. Antimicrob Agents Chemother. 2005 Mar;49(3):981-6 - PubMed
  29. Elife. 2012 Nov 13;1:e00049 - PubMed
  30. J Antibiot (Tokyo). 1966 Nov;19(6):286-7 - PubMed
  31. World J Gastroenterol. 2014 Jun 28;20(24):7707-17 - PubMed
  32. Antiviral Res. 2014 May;105:17-21 - PubMed
  33. Antimicrob Agents Chemother. 2001 Mar;45(3):743-8 - PubMed
  34. Antimicrob Agents Chemother. 2002 Apr;46(4):977-81 - PubMed
  35. Antimicrob Agents Chemother. 2014 Jun;58(6):3327-34 - PubMed
  36. PLoS Pathog. 2011 Oct;7(10):e1002331 - PubMed
  37. Nature. 2008 Jan 31;451(7178):596-9 - PubMed
  38. J Virol. 1971 Jul;8(1):28-34 - PubMed
  39. Sci Rep. 2017 Feb 03;7:41851 - PubMed
  40. Nature. 2014 Apr 17;508(7496):402-5 - PubMed
  41. Eur J Med Chem. 2014 Mar 21;75:267-81 - PubMed
  42. J Antibiot (Tokyo). 1989 Apr;42(4):644-6 - PubMed
  43. J Virol. 1993 Aug;67(8):4688-95 - PubMed
  44. Antimicrob Agents Chemother. 1997 Sep;41(9):1949-52 - PubMed
  45. World J Gastroenterol. 2016 Jan 7;22(1):188-204 - PubMed
  46. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4485-92 - PubMed
  47. J Antibiot (Tokyo). 1967 Jul;20(4):227-31 - PubMed
  48. Intervirology. 2014;57(3-4):158-62 - PubMed
  49. J Antibiot (Tokyo). 1970 May;23(5):259-62 - PubMed
  50. J Med Chem. 1994 Mar 4;37(5):616-24 - PubMed
  51. Antiviral Res. 2010 Jun;86(3):241-5 - PubMed
  52. Mol Med Rep. 2014 Jun;9(6):2221-6 - PubMed
  53. J Virol. 2005 Feb;79(3):1613-22 - PubMed
  54. J Antibiot (Tokyo). 1981 Sep;34(9):1216-8 - PubMed
  55. FEBS Lett. 1976 Dec 31;72(2):323-6 - PubMed
  56. J Antibiot (Tokyo). 1967 Sep;20(5):277-81 - PubMed
  57. J Antibiot (Tokyo). 1969 Jun;22(6):283-6 - PubMed
  58. Nat Med. 1998 May;4(5):610-4 - PubMed
  59. Acta Pharmacol Sin. 2014 Mar;35(3):410-8 - PubMed
  60. J Antibiot (Tokyo). 1989 Apr;42(4):611-9 - PubMed
  61. Drugs Exp Clin Res. 1988;14(12):719-22 - PubMed
  62. J Antibiot (Tokyo). 1972 Apr;25(4):263-6 - PubMed
  63. Antimicrob Agents Chemother. 1977 Jun;11(6):946-51 - PubMed
  64. FEBS Lett. 1989 Apr 10;247(1):113-7 - PubMed
  65. Nat Chem Biol. 2005 Nov;1(6):333-7 - PubMed
  66. J Hepatol. 2009 Sep;51(3):581-92 - PubMed
  67. Science. 1972 Aug 25;177(4050):705-6 - PubMed
  68. Biochem Int. 1991 May;24(1):165-71 - PubMed
  69. Chem Rev. 2015 Sep 23;115(18):9655-706 - PubMed
  70. J Antibiot (Tokyo). 2002 Feb;55(2):155-64 - PubMed
  71. Arch Virol. 2005 Mar;150(3):521-32 - PubMed
  72. Clin Microbiol Rev. 2016 Jul;29(3):695-747 - PubMed
  73. Antiviral Res. 2017 Jan;137:14-22 - PubMed
  74. J Virol. 2013 Apr;87(7):3741-51 - PubMed
  75. J Virol. 2004 Sep;78(18):10166-77 - PubMed
  76. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6406-11 - PubMed
  77. World J Gastroenterol. 2015 Nov 28;21(44):12558-75 - PubMed
  78. Antiviral Res. 1982 May;2(1-2):69-79 - PubMed
  79. J Antibiot (Tokyo). 1983 Sep;36(9):1242-4 - PubMed
  80. J Med Chem. 2014 Aug 14;57(15):6668-78 - PubMed
  81. J Antibiot (Tokyo). 1976 Jan;29(1):97-9 - PubMed
  82. Cancer Genomics Proteomics. 2011 May-Jun;8(3):105-26 - PubMed
  83. J Am Chem Soc. 1997 Jan 29;119(4):681-90 - PubMed
  84. Nucleic Acids Symp Ser. 1999;(42):19-20 - PubMed
  85. J Antibiot (Tokyo). 1986 Apr;39(4):589-93 - PubMed
  86. J Hepatol. 2013 May;58(5):861-7 - PubMed
  87. J Hepatol. 2014 Apr;60(4):723-31 - PubMed
  88. Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14 - PubMed
  89. Antiviral Res. 2013 Sep;99(3):221-9 - PubMed
  90. Hepatology. 2003 Nov;38(5):1282-8 - PubMed
  91. Nature. 1993 Jun 3;363(6428):418-23 - PubMed
  92. Annu Rev Virol. 2017 Sep 29;4(1):105-121 - PubMed
  93. J Antibiot (Tokyo). 1980 Jan;33(1):83-4 - PubMed
  94. PLoS One. 2013 Jul 10;8(7):e68347 - PubMed
  95. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2235-9 - PubMed
  96. J Virol. 2004 Nov;78(21):12062-5 - PubMed
  97. Nat Rev Microbiol. 2016 Aug;14 (8):479-93 - PubMed
  98. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9396-401 - PubMed
  99. Antimicrob Agents Chemother. 2013 Nov;57(11):5202-8 - PubMed
  100. J Med Virol. 2011 Apr;83(4):587-93 - PubMed
  101. J Antibiot (Tokyo). 1989 Feb;42(2):344-6 - PubMed
  102. J Antibiot (Tokyo). 1973 Dec;26(12):787-9 - PubMed
  103. Hepatology. 2006 Jul;44(1):117-25 - PubMed
  104. Virology. 2012 Mar 1;424(1):3-10 - PubMed
  105. PLoS One. 2012;7(5):e37277 - PubMed
  106. Antimicrob Agents Chemother. 1994 Apr;38(4):707-12 - PubMed
  107. Sci Rep. 2017 Mar 06;7:43395 - PubMed
  108. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1174-8 - PubMed
  109. Nature. 2016 Mar 17;531(7594):381-5 - PubMed
  110. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82 - PubMed
  111. Org Lett. 2002 Dec 12;4(25):4483-6 - PubMed
  112. J Antibiot (Tokyo). 1972 Feb;25(2):109-15 - PubMed
  113. J Antibiot (Tokyo). 1964 May;17:96-9 - PubMed
  114. Virology. 1974 Apr;58(2):457-63 - PubMed

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