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Showing 1 to 12 of 2335 entries
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Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells.

Journal of toxicology

Saito R, Terasaki N, Yamazaki M, Masutomi N, Tsutsui N, Okamoto M.
PMID: 27057163
J Toxicol. 2016;2016:4041827. doi: 10.1155/2016/4041827. Epub 2016 Feb 17.

Adrenal toxicity is one of the major concerns in drug development. To quantitatively understand the effect of endocrine-active compounds on adrenal steroidogenesis and to assess the human adrenal toxicity of novel pharmaceutical drugs, we developed a mathematical model of...

Protein kinase D regulates positive selection of CD4.

Nature communications

Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.
PMID: 27670070
Nat Commun. 2016 Sep 27;7:12756. doi: 10.1038/ncomms12756.

Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development. Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for thymocyte positive selection. In T cell-specific PKD-deficient (PKD2/PKD3 double-deficient) mice,...

A rare adult case of poststreptococcal acute glomerulonephritis with a retropharyngeal abscess.

CEN case reports

Takashima T, Hirata S, Nonaka M, Matsumoto K, Awanami Y, Yamasaki M, Fukuda M, Miyazono M, Ikeda Y.
PMID: 28509140
CEN Case Rep. 2017 May;6(1):118-123. doi: 10.1007/s13730-017-0256-3. Epub 2017 Mar 27.

Retropharyngeal abscess is an infection involving the retropharyngeal space which is posterior to the pharynx and oesophagus, and it results as a complication of a primary infection elsewhere in the head and neck including the nasopharynx, paranasal sinuses, or...

Diabetic Neuropathy Evaluated by a Novel Device: Sural Nerve Conduction Is Associated with Glycemic Control and Ankle-Brachial Pressure Index in Japanese Patients with Diabetes.

Frontiers in endocrinology

Hamasaki H, Hamasaki Y.
PMID: 28861044
Front Endocrinol (Lausanne). 2017 Aug 15;8:203. doi: 10.3389/fendo.2017.00203. eCollection 2017.

BACKGROUND: Currently, no international diagnostic criteria for diabetic neuropathy (DN) have been established. Recently, a novel point-of-care sural nerve conduction device has been developed. We aimed to investigate associations between DN and clinical parameters related to the development and...

Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report.

Journal of neurological surgery reports

Sakai N, Ito-Yamashita T, Takahashi G, Baba S, Koizumi S, Yamasaki T, Tokuyama T, Namba H.
PMID: 25083392
J Neurol Surg Rep. 2014 Aug;75(1):e62-6. doi: 10.1055/s-0033-1363505. Epub 2014 Jan 16.

Primary neurolymphomatosis is an extremely rare tumor. We report the case of a 74-year-old patient presenting with dysphagia and hoarseness. Initial contrast-enhanced computed tomography of the head, neck, and chest did not reveal any lesions. His symptoms improved with...

Interferon-β and temozolomide combination therapy for temozolomide monotherapy-refractory malignant gliomas.

Molecular and clinical oncology

Kawaji H, Tokuyama T, Yamasaki T, Amano S, Sakai N, Namba H.
PMID: 26171205
Mol Clin Oncol. 2015 Jul;3(4):909-913. doi: 10.3892/mco.2015.542. Epub 2015 Apr 08.

Interferon-β (IFN-β) has been found to downregulate O

RNA-seq Transcriptome Analysis of Panax japonicus, and Its Comparison with Other Panax Species to Identify Potential Genes Involved in the Saponins Biosynthesis.

Frontiers in plant science

Rai A, Yamazaki M, Takahashi H, Nakamura M, Kojoma M, Suzuki H, Saito K.
PMID: 27148308
Front Plant Sci. 2016 Apr 12;7:481. doi: 10.3389/fpls.2016.00481. eCollection 2016.

The Panax genus has been a source of natural medicine, benefitting human health over the ages, among which the Panax japonicus represents an important species. Our understanding of several key pathways and enzymes involved in the biosynthesis of ginsenosides,...

Endovascular Treatment of Left Subclavian Artery Pseudoaneurysm after Clavicle Fracture in an Elderly Adult with a 40-Year History of Behçet's Disease.

Annals of vascular diseases

Nishimura K, Hamasaki T, Yamamoto S, Kawai T, Sugiura K.
PMID: 26730261
Ann Vasc Dis. 2015;8(4):328-30. doi: 10.3400/avd.cr.15-00082. Epub 2015 Oct 15.

Behçet's disease (BD) is a rare chronic systemic vasculitis of unknown etiology that presents in young adults. We report a very rare case of a left subclavian artery pseudoaneurysm identified after a left clavicle fracture in a 70-year-old man...

Carcinoid tumor of the extrahepatic bile duct: report of a case.

Clinical journal of gastroenterology

Yasuda T, Imai G, Takemoto M, Yamasaki M, Ishikawa H, Kitano M, Nakai T, Takeyama Y.
PMID: 26181459
Clin J Gastroenterol. 2013 Apr;6(2):177-87. doi: 10.1007/s12328-013-0373-2. Epub 2013 Mar 23.

We report a rare case of carcinoid tumor of the extrahepatic bile duct. A 69-year-old woman with a history of hyperthyroidism was diagnosed to have a tumor of the extrahepatic bile duct. Laparotomy, for presumed cholangiocarcinoma, revealed a 2.5-cm-long,...

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease.

Journal of neurogastroenterology and motility

Tomita T, Kato Y, Takimoto M, Yamasaki T, Kondo T, Kono T, Tozawa K, Yokoyama Y, Ikehara H, Ohda Y, Oshima T, Fukui H, Tanaka S, Shima M, Watari J, Miwa H.
PMID: 27193973
J Neurogastroenterol Motil. 2016 Oct 30;22(4):661-669. doi: 10.5056/jnm15160.

BACKGROUND/AIMS: Few studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has 3 objectives: (1) to assess the prevalence of IBS-like...

Baastrup's Disease Is Associated with Recurrent of Sciatica after Posterior Lumbar Spinal Decompressions Utilizing Floating Spinous Process Procedures.

Asian spine journal

Koda M, Mannoji C, Murakami M, Kinoshita T, Hirayama J, Miyashita T, Eguchi Y, Yamazaki M, Suzuki T, Aramomi M, Ota M, Maki S, Takahashi K, Furuya T.
PMID: 27994785
Asian Spine J. 2016 Dec;10(6):1085-1090. doi: 10.4184/asj.2016.10.6.1085. Epub 2016 Dec 08.

STUDY DESIGN: Retrospective case-control study.PURPOSE: To determine whether kissing spine is a risk factor for recurrence of sciatica after lumbar posterior decompression using a spinous process floating approach.OVERVIEW OF LITERATURE: Kissing spine is defined by apposition and sclerotic change...

Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection after observation of chronological changes: A case report.

World journal of gastrointestinal oncology

Kawara F, Tanaka S, Yamasaki T, Morita Y, Ohara Y, Okabe Y, Hoshi N, Toyonaga T, Umegaki E, Yokozaki H, Hirose T, Azuma T.
PMID: 28656077
World J Gastrointest Oncol. 2017 Jun 15;9(6):263-267. doi: 10.4251/wjgo.v9.i6.263.

A 66-year-old man was diagnosed with a gastric submucosal tumor. Endoscopic ultrasound (EUS) revealed an iso/hypoechoic mass in the third layer. No malignant cells were detected in a histological examination. Yearly follow-up endoscopy and EUS showed the slow growth...

Showing 1 to 12 of 2335 entries