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Whittaker DG, Ni H, Benson AP, et al. Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. Front Physiol. 2017;8:759doi: 10.3389/fphys.2017.00759.
Whittaker, D. G., Ni, H., Benson, A. P., Hancox, J. C., & Zhang, H. (2017). Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. Frontiers in physiology, 8759. https://doi.org/10.3389/fphys.2017.00759
Whittaker, Dominic G, et al. "Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles." Frontiers in physiology vol. 8 (2017): 759. doi: https://doi.org/10.3389/fphys.2017.00759
Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. Front Physiol. 2017 Oct 04;8:759. doi: 10.3389/fphys.2017.00759. eCollection 2017. PMID: 29085299; PMCID: PMC5649182.
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Front Physiol. 2017 Oct 04;8:759. doi: 10.3389/fphys.2017.00759. eCollection 2017.

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles.

Frontiers in physiology

Dominic G Whittaker, Haibo Ni, Alan P Benson, Jules C Hancox, Henggui Zhang

Affiliations

  1. Biological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, United Kingdom.
  2. School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
  3. Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, United Kingdom.
  4. School of Physiology, Pharmacology and Neuroscience, Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom.
  5. School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
  6. Space Institute of Southern China, Shenzhen, China.

PMID: 29085299 PMCID: PMC5649182 DOI: 10.3389/fphys.2017.00759

Abstract

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current,

Keywords: arrhythmia; class 1a anti-arrhythmics; drug modeling; human ventricles; potassium channels; short QT syndrome

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