Display options
Cite
Liu X, Zhou Y, Liang N, et al. The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery. Gland Surg. 2017;6(5):443-452doi: 10.21037/gs.2017.09.05.
Liu, X., Zhou, Y., Liang, N., Hong, Y., Dionigi, G., & Sun, H. (2017). The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery. Gland surgery, 6(5), 443-452. https://doi.org/10.21037/gs.2017.09.05
Liu, Xiaoli, et al. "The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery." Gland surgery vol. 6,5 (2017): 443-452. doi: https://doi.org/10.21037/gs.2017.09.05
Liu X, Zhou Y, Liang N, Hong Y, Dionigi G, Sun H. The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery. Gland Surg. 2017 Oct;6(5):443-452. doi: 10.21037/gs.2017.09.05. PMID: 29142833; PMCID: PMC5676168.
Copy Download .nbib Format: NLM
Share it on

Gland Surg. 2017 Oct;6(5):443-452. doi: 10.21037/gs.2017.09.05.

The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery.

Gland surgery

Xiaoli Liu, Ying Zhou, Nan Liang, Yang Hong, Gianlorenzo Dionigi, Hui Sun

Affiliations

  1. Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun 130031, China.
  2. Division for Endocrine Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Messina, Italy.

PMID: 29142833 PMCID: PMC5676168 DOI: 10.21037/gs.2017.09.05

Abstract

BACKGROUND: To analyze the effect of long-term thyroid-stimulating hormone (TSH) suppressive therapy on the gonadal hormones and related symptoms in patients after surgery.

METHODS: From 2008 to 2011, totally 238 patients were recruited, who underwent thyroid surgery and subsequent TSH suppression treatment in Department of thyroid Surgery, China-Japan Union hospital, Jilin University. Then their postoperative follow-up data (3-8 years) were collected, including operational method, pathological diagnosis, whether processed radioiodine therapy and the period/dose of TSH suppression treatment. In addition, the menstrual cycle, menstruation quantity, whether accompanied with dysmenorrheal and menstrual disorder or not, date of last menstrual period, ages of menopause and so on were also collected.

RESULTS: (I) Neither the level nor the duration of TSH treatment had any function on estradiol (E2) and testosterone (T) in male patients; (II) in the subgroup of patients with TSH treatment for 3-5 years, patients who took high dose of TSH (TSH ≥0.5 U/L) obtained the lower T level compared with the group of medium dose (1.08±0.34

CONCLUSIONS: The long term of TSH repressive therapy after surgery did not affect T and E2 level in male patients. As for female patients, the impact was mainly reflected in the T and E2 levels especially in female sexual maturity but not FSH level. In addition, TSH treatment did not play any role on menstruation or menopause.

Keywords: TSH; Thyroid carcinoma; gonadal hormones; thyroid-stimulating hormone repressive therapy

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

References

  1. Thyroid. 2011 Nov;21(11):1175-6 - PubMed
  2. Clin Endocrinol (Oxf). 2003 Mar;58(3):340-7 - PubMed
  3. Tohoku J Exp Med. 2003 Oct;201(2):81-9 - PubMed
  4. Lancet. 2001 Sep 15;358(9285):861-5 - PubMed
  5. J Clin Endocrinol Metab. 2008 Apr;93(4):1167-9 - PubMed
  6. J Bone Miner Metab. 2016 Jul;34(4):417-21 - PubMed
  7. J Clin Pathol. 1989 Dec;42(12):1237-40 - PubMed
  8. Surgery. 1988 Feb;103(2):268-9 - PubMed
  9. Thyroid. 2016 Jan;26(1):1-133 - PubMed
  10. Lancet. 2012 Mar 24;379(9821):1142-54 - PubMed
  11. Osteoporos Int. 2007 Jan;18(1):85-92 - PubMed
  12. Endocr Rev. 2008 Feb;29(1):76-131 - PubMed
  13. Fertil Steril. 2004 Mar;81 Suppl 1:919-24 - PubMed
  14. Thyroid. 2010 Feb;20(2):135-46 - PubMed
  15. Minerva Med. 2000 Nov-Dec;91(11-12):283-9 - PubMed
  16. Eur Arch Psychiatry Clin Neurosci. 1992;241(6):357-64 - PubMed
  17. Postgrad Med J. 2001 Jan;77(903):29-32 - PubMed
  18. Cancer. 1985 Jun 1;55(11):2691-7 - PubMed

Publication Types