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Lim MJ, Jang HJ, Yu MK, et al. Removal efficacy and cytotoxicity of a calcium hydroxide paste using . Restor Dent Endod. 2017;42(4):290-300doi: 10.5395/rde.2017.42.4.290.
Lim, M. J., Jang, H. J., Yu, M. K., Lee, K. W., & Min, K. S. (2017). Removal efficacy and cytotoxicity of a calcium hydroxide paste using . Restorative dentistry & endodontics, 42(4), 290-300. https://doi.org/10.5395/rde.2017.42.4.290
Lim, Myung-Jin, et al. "Removal efficacy and cytotoxicity of a calcium hydroxide paste using ." Restorative dentistry & endodontics vol. 42,4 (2017): 290-300. doi: https://doi.org/10.5395/rde.2017.42.4.290
Lim MJ, Jang HJ, Yu MK, Lee KW, Min KS. Removal efficacy and cytotoxicity of a calcium hydroxide paste using . Restor Dent Endod. 2017 Nov;42(4):290-300. doi: 10.5395/rde.2017.42.4.290. Epub 2017 Oct 20. PMID: 29142877; PMCID: PMC5682145.
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Restor Dent Endod. 2017 Nov;42(4):290-300. doi: 10.5395/rde.2017.42.4.290. Epub 2017 Oct 20.

Removal efficacy and cytotoxicity of a calcium hydroxide paste using .

Restorative dentistry & endodontics

Myung-Jin Lim, Hyun-Jin Jang, Mi-Kyung Yu, Kwang-Won Lee, Kyung-San Min

Affiliations

  1. Department of Conservative Dentistry, Chonbuk National University School of Dentistry and Institute of Oral Bioscience, Jeonju, Korea.
  2. Department of Life Science, College of Natural Sciences, Chonbuk National University, Jeonju, Korea.
  3. Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea.
  4. Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

PMID: 29142877 PMCID: PMC5682145 DOI: 10.5395/rde.2017.42.4.290

Abstract

OBJECTIVES: This study investigated the removal efficacy and cytotoxicity of a newly developed calcium hydroxide paste (cleaniCal, Maruchi) using

MATERIALS AND METHODS: Thirty maxillary premolars with oval-shaped canals were divided into 3 groups and the teeth were filled with one of the pastes. After removal of the paste, micro-computed tomographic (μ-CT) imaging was obtained to assess the volume of residual paste in the root canal of each tooth. The teeth were then split longitudinally and the area of the paste-coated surface was evaluated by stereomicroscopy. The cytotoxicity of each product was assessed using an agar overlay assay. The effect of each vehicle on cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using one-way analysis of variance and Tukey's tests to detect any significance (

RESULTS: In the μ-CT and stereomicroscopic analysis, cleaniCal exhibited less remnants of medicament than ApexCal and Calcipex. cleaniCal showed a higher cytotoxicity than the other pastes in the agar overlay assay. Furthermore, NMP exhibited lower cell viability compared to the other vehicles.

CONCLUSIONS: cleaniCal showed better removal efficacy compared to the other products. However, clinicians should be aware of the higher cytotoxicity of the NMP-based material and consider its possible adverse effects on periradicular tissue when it is overfilled.

Keywords: Calcium hydroxide; Cytotoxicity; N-methylpyrrolidone; Removal

Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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