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Chronic Dis Transl Med. 2016 Nov 03;2(2):110-119. doi: 10.1016/j.cdtm.2016.09.004. eCollection 2016 Jun.

Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients.

Chronic diseases and translational medicine

Yi-Nan Li, Bryan Shapiro, Jun Chul Kim, Min Zhang, Janos Porszasz, Rachelle Bross, Usama Feroze, Rajeev Upreti, David Martin, Kamyar Kalantar-Zadeh, Joel David Kopple

Affiliations

  1. Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center, Torrance, CA 90502, USA.
  2. Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
  3. Division of Nephrology, CHA Gumi Medical Center, CHA University, Kyungsangbuk-do 730728, South Korea.
  4. Division of Nephrology, Tianjin Union Medical Center, Tianjin 300121, China.
  5. Rehabilitation Clinical Trials Center, Division of Respiratory & Critical Care Physiology & Medicine, Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center, Torrance, CA 90502, USA.
  6. UCLA Clinical and Translational Science Institute, Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center, Torrance, CA 90502, USA.
  7. Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center, Torrance, CA 90502, USA.
  8. George Washington University/Inova Fairfax Hospital Psychosomatic Fellowship Program, Washington, DC 20052, USA.
  9. Max Super Specialty Hospital, New Delhi, Delhi 110092, India.
  10. Division of Psychology, Department of Psychiatry, Harbor - UCLA Medical Center, Torrance, CA 90502, USA.
  11. Division of Nephrology and Hypertension, University of California at Irvine, Irvine, CA 92697, USA.
  12. UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA.
  13. David Geffen School of Medicine at UCLA, Los Angeles, CA 90502, USA.

PMID: 29063031 PMCID: PMC5643749 DOI: 10.1016/j.cdtm.2016.09.004

Abstract

OBJECTIVE: Maintenance hemodialysis (MHD) patients often have impaired quality of life (QOL), anxiety, depression, and reduced daily physical activity (DPA) and physical performance. The contributions of these latter factors to reduced QOL in MHD are poorly understood. We examined the association of QOL with anxiety, depression, DPA, and physical performance.

METHODS: Seventy-two relatively healthy adult MHD patients, vintage ≥6 months, and 39 normals of similar age range and gender distribution were studied. QOL was assessed using the Kidney Disease Quality of Life-Short Form (KDQOL-SF). Anxiety and depression were each evaluated with two questionnaires. DPA and physical performance were assessed with a physical activity monitor, Human Activity Profile, and 6-minute walk, sit-to-stand, and stair-climbing tests.

RESULTS: Most KDQOL components were reduced in MHD patients versus normals. KDQOL components in patients were commonly inversely correlated with measures of anxiety and depression (

CONCLUSION: In relatively healthy MHD patients, KDQOL scores are usually decreased in those with anxiety and/or depression but are usually normal in those without anxiety or depression. Lower DPA in MHD patients with reduced KDQOL scores often appears to be associated with anxiety and depression. The relationship between QOL and physical performance appears to be less influenced by anxiety and/or depression. These data suggest that treatment of anxiety and depression in MHD patients may improve their QOL, DPA, and possibly physical performance.

Keywords: Anxiety; Depression; Kidney disease; Kidney failure; Quality of life

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