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Qin Q, Yang L, Sun YK, et al. Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival. Chronic Dis Transl Med. 2017;3(1):51-59doi: 10.1016/j.cdtm.2017.02.004.
Qin, Q., Yang, L., Sun, Y. K., Ying, J. M., Song, Y., Zhang, W., Wang, J. W., & Zhou, A. P. (2017). Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival. Chronic diseases and translational medicine, 3(1), 51-59. https://doi.org/10.1016/j.cdtm.2017.02.004
Qin, Qiong, et al. "Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival." Chronic diseases and translational medicine vol. 3,1 (2017): 51-59. doi: https://doi.org/10.1016/j.cdtm.2017.02.004
Qin Q, Yang L, Sun YK, Ying JM, Song Y, Zhang W, Wang JW, Zhou AP. Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival. Chronic Dis Transl Med. 2017 Mar 13;3(1):51-59. doi: 10.1016/j.cdtm.2017.02.004. eCollection 2017 Mar 25. PMID: 29063056; PMCID: PMC5627696.
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Chronic Dis Transl Med. 2017 Mar 13;3(1):51-59. doi: 10.1016/j.cdtm.2017.02.004. eCollection 2017 Mar 25.

Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology, recurrence, and survival.

Chronic diseases and translational medicine

Qiong Qin, Lin Yang, Yong-Kun Sun, Jian-Ming Ying, Yan Song, Wen Zhang, Jin-Wan Wang, Ai-Ping Zhou

Affiliations

  1. Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
  2. Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
  3. Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

PMID: 29063056 PMCID: PMC5627696 DOI: 10.1016/j.cdtm.2017.02.004

Abstract

OBJECTIVE: Recent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS).

METHODS: We identified patients from 2005 to 2008 with stage II/III colon cancer who underwent surgery for curative intent. We explored the impact of the tumor location on the postoperative DFS and OS using univariate and multivariate analyses.

RESULTS: Of 627 patients, 50.6% (317/627) had right-sided colon cancer. These patients were more likely to have weight loss, second primary tumor, elevated preoperative carbohydrate antigen 19-9 (CA19-9), increased incidence of non-adenocarcinoma, more poorly differentiated tumors, vascular invasion, defective mismatch repair, and a lighter smoking history (

CONCLUSION: We found that right- and left-sided colon cancers had significantly different clinicopathological characteristics. Right-sided colon cancer had a higher incidence of recurrence than left-sided disease. Patients with stage III right-sided colon cancer had a worse prognosis compared with those with stage III left-sided colon cancer.

Keywords: Colon cancer; Location; Recurrence; Survival

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