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Child Psychiatry Hum Dev. 2018 Aug;49(4):493-504. doi: 10.1007/s10578-017-0768-2.

Screening Accuracy of the Brief Infant Toddler Social-Emotional Assessment to Identify Autism Spectrum Disorder in Toddlers Born at Less Than 30 Weeks' Gestation.

Child psychiatry and human development

Kelly M Boone, Anne K Brown, Sarah A Keim

Affiliations

  1. Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. [email protected].
  2. Crane Center for Early Childhood Research and Policy and Schoenbaum Family Center, The Ohio State University, 175 East 7th Avenue, Columbus, OH, 43201, USA. [email protected].
  3. Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  4. Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA.
  5. Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA.

PMID: 29147839 DOI: 10.1007/s10578-017-0768-2

Abstract

Despite the higher prevalence of autism spectrum disorder (ASD) in children born preterm, valid screening tools for use in preterm populations are lacking. We aimed to evaluate the screening accuracy of the Brief Infant Toddler Social-Emotional Assessment (BITSEA) and to compare it to the Pervasive Developmental Disorders Screening Test-II, Stage 2, Developmental Clinic Screener (PDDST-II-DCS) in identifying ASD diagnosis in toddlers born at < 30 weeks' gestation. Caregivers (94% mothers) of 555 children completed questionnaires (BITSEA, PDDST-II-DCS, socio-demographics) when the children (58% male) were 18-36 months. Medical charts were abstracted 3.5 years later and showed that 4% (n = 24) of children had an ASD diagnosis. BITSEA competence (sensitivity = .74; specificity = .76) and ASD (sensitivity = .70; specificity = .73) subscales demonstrated better accuracy in identifying ASD compared to the recommended PDDST-II-DCS cut-score (sensitivity = .73; specificity = .64), specifically as it related to specificity. Additional studies are needed in other preterm populations to replicate these findings.

Keywords: ASD screening; Autism spectrum disorder; BITSEA; Prematurity

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