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Okamoto O, Sato S, Sakai T, et al. Comparative analysis of mamushi (. Acute Med Surg. 2015;3(2):120-127doi: 10.1002/ams2.174.
Okamoto, O., Sato, S., Sakai, T., Uehara, M., Takenaka, R., Ito, A., Shono, T., Takeo, N., Ishikawa, K., Shimizu, F., Shimada, H., Hatano, Y., Fujiwara, S., & Hashimoto, H. (2016). Comparative analysis of mamushi (. Acute medicine & surgery, 3(2), 120-127. https://doi.org/10.1002/ams2.174
Okamoto, Osamu, et al. "Comparative analysis of mamushi (." Acute medicine & surgery vol. 3,2 (2016): 120-127. doi: https://doi.org/10.1002/ams2.174
Okamoto O, Sato S, Sakai T, Uehara M, Takenaka R, Ito A, Shono T, Takeo N, Ishikawa K, Shimizu F, Shimada H, Hatano Y, Fujiwara S, Hashimoto H. Comparative analysis of mamushi (. Acute Med Surg. 2015 Nov 27;3(2):120-127. doi: 10.1002/ams2.174. eCollection 2016 Apr. PMID: 29123763; PMCID: PMC5667372.
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Acute Med Surg. 2015 Nov 27;3(2):120-127. doi: 10.1002/ams2.174. eCollection 2016 Apr.

Comparative analysis of mamushi (.

Acute medicine & surgery

Osamu Okamoto, Seiichi Sato, Takashi Sakai, Miyuki Uehara, Ryuichi Takenaka, Akiko Ito, Tomoko Shono, Naoko Takeo, Kazushi Ishikawa, Fumiaki Shimizu, Hiromitsu Shimada, Yutaka Hatano, Sakuhei Fujiwara, Hiroyuki Hashimoto

Affiliations

  1. Dermatology Unit Oita City Medical Association's Almeida Memorial Hospital Oita Japan.
  2. Plastic Surgery Unit Oita City Medical Association's Almeida Memorial Hospital Oita Japan.
  3. Department of Dermatology Faculty of Medicine Oita University Oita Japan.
  4. Department of Plastic Surgery Faculty of Medicine Oita University Oita Japan.
  5. Department of Emergency Medicine Faculty of Medicine Oita University Oita Japan.

PMID: 29123763 PMCID: PMC5667372 DOI: 10.1002/ams2.174

Abstract

AIM: There has been no indicator that allows an early quantitative evaluation of the severity of a mamushi snake (

METHODS: We enrolled patients who presented with a mamushi bite and visited our outpatient clinic. Severe cases were collected from published works. Creatinine kinase levels and white blood cell counts of non-severe and severe cases were compared and analyzed.

RESULTS: There was a lag time of 10 h before the creatinine kinase level began to rise. The speed of the increase was higher in severe cases than in non-severe cases, and severe cases were recognized as those showing speeds of above 250 IU/L/h. White blood cell counts increased earlier than creatinine kinase levels without any lag time. Severe cases were recognized as those with the counts of over 1,000 × (h) + 6,000 [/μL] before 5 h and 300 × (h) + 10,000 [/μL] after 5 h.

CONCLUSION: We herein present the creatinine kinase level and white blood cell count trends and demonstrate preliminary cut-off equations. The trends for both parameters serve as quantitative indicators of the severity of a mamushi bite until a large scale case-control study is achieved.

Keywords: Creatinine kinase; Gloydius blomhoffii; cut‐off equation; mamushi bite; white blood cell count

References

  1. Nihon Naika Gakkai Zasshi. 2000 Nov 10;89(11):2350-2 - PubMed
  2. J Dermatol. 2009 May;36(5):277-83 - PubMed
  3. J Biochem. 1972 Dec;72(6):1483-94 - PubMed

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